股本结构
单位：万股
| 公告日期 | 2024-03-06 | 2024-03-06 | 2023-11-13 | 2023-11-13 | 2023-08-07 | 2023-08-07 |
|---|---|---|---|---|---|---|
| 证券总股本 | 5465.64 | 5448.07 | 5448.07 | 5447.18 | 5407.77 | 5406.88 |
| 普通股本 | 5465.64 | 5448.07 | 5448.07 | 5447.18 | 5407.77 | 5406.88 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2024-03-01 | 2023-12-31 | 2023-11-09 | 2023-09-30 | 2023-08-03 | 2023-06-30 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2024-03-06 | 5465.64 | 未披露 | 定期报告 | 2024-03-01 |
| 2024-03-06 | 5448.07 | 未披露 |
更多>>
From December 31,2022 to December 31,2023
Net proceeds from sales of common stock under open market sales agreement
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
|
2023-12-31 |
| 2023-11-13 | 5448.07 | 未披露 | 定期报告 | 2023-11-09 |
| 2023-11-13 | 5447.18 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Net proceeds from sales of common stock under open market sales agreement
Shares issued upon vesting of restricted stock units
|
2023-09-30 |
| 2023-08-07 | 5407.77 | 未披露 | 定期报告 | 2023-08-03 |
| 2023-08-07 | 5406.88 | 未披露 |
更多>>
From March 31, 2023 to June 30, 2023
Shares issued upon vesting of restricted stock units
|
2023-06-30 |
| 2023-05-15 | 5398.32 | 未披露 | 定期报告 | 2023-05-11 |
| 2023-05-15 | 5397.44 | 未披露 |
更多>>
From December 31, 2022 to March 31, 2023
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
|
2023-03-31 |
| 2023-03-06 | 5394.34 | 未披露 | 定期报告 | 2023-03-02 |
| 2023-03-06 | 5379.73 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
|
2022-12-31 |
| 2022-11-07 | 5373.36 | 未披露 |
更多>>
From June 30, 2022 to September 30, 2022
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
|
2022-09-30 |
| 2022-08-08 | 5372.59 | 未披露 | 定期报告 | 2022-08-04 |
| 2022-05-09 | 5359.12 | 未披露 |
更多>>
From December 31, 2021 to March 31, 2022
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
|
2022-03-31 |
| 2022-03-01 | 5351.35 | 未披露 | 定期报告 | 2022-02-24 |
| 2022-03-01 | 5348.08 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Sale of common stock under license agreement with Vifor ($15.23 per share)
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
|
2021-12-31 |
| 2021-11-08 | 5345.87 | 未披露 | 定期报告 | 2021-11-04 |
| 2021-11-08 | 5017.60 | 未披露 |
更多>>
From June 30, 2021 to September 30, 2021
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
|
2021-09-30 |
| 2021-08-09 | 5008.99 | 未披露 | 定期报告 | 2021-08-05 |
| 2021-08-09 | 5008.82 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
|
2021-06-30 |
| 2021-05-10 | 5005.20 | 未披露 | 定期报告 | 2021-05-06 |
| 2021-04-23 | 5004.16 | 未披露 | 定期报告 | 2021-04-12 |
| 2021-04-23 | 5002.82 | 未披露 | 定期报告 | 2021-04-05 |
| 2021-05-10 | 5002.67 | 未披露 |
更多>>
From December 31, 2020 to March 31, 2021
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
|
2021-03-31 |
| 2021-02-25 | 4987.68 | 未披露 | 定期报告 | 2021-02-22 |
| 2021-02-25 | 4987.22 | 未披露 |
更多>>
From December 31,2019 to December 31,2020
Sale of common stock under license agreement
Shares issued upon vesting of restricted stock units
Shares issued upon exercise of stock options
|
2020-12-31 |
| 2020-11-09 | 4983.21 | 未披露 | 定期报告 | 2020-11-05 |
| 2020-11-09 | 4689.26 | 未披露 |
更多>>
From June 30, 2020 to September 30, 2020
Shares issued upon exercise of stock options
|
2020-09-30 |
| 2020-08-10 | 4688.68 | 未披露 | 定期报告 | 2020-08-06 |
| 2020-08-10 | 4686.44 | 未披露 |
更多>>
From March 31, 2020 to June 30, 2020
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
|
2020-06-30 |
| 2020-05-11 | 4679.61 | 未披露 | 定期报告 | 2020-05-07 |
| 2020-05-11 | 4672.77 | 未披露 |
更多>>
From December 31, 2019 to March 31, 2020
Shares issued upon exercise of stock options
|
2020-03-31 |
| 2020-02-27 | 4672.52 | 未披露 | 定期报告 | 2020-02-24 |
| 2020-02-27 | 4672.02 | 未披露 |
更多>>
from December 31, 2018 to December 31, 2019
Sale of common stock in a follow-on public offering ($23.00 per share), net of underwriting discounts and commissions and offering expenses of $8,977
Issuance of common stock upon entry into License Agreement with Enteris Biopharma, Inc. ($23.42 per share)
Shares issued upon exercise of stock options
Shares issued upon vesting of executive restricted stock units
Shares issued for consulting services
|
2019-12-31 |
| 2019-11-05 | 4667.90 | 未披露 | 定期报告 | 2019-11-01 |
| 2019-11-05 | 4667.40 | 未披露 |
更多>>
from June 30, 2019 to September 30, 2019
Sale of common stock in a follow-on public offering ($23.00 per share), net of underwriting discounts and commissions and offering expenses of $8,950
Issuance of common stock upon entry into License Agreement with Enteris Biopharma, Inc. ($23.42 per share)
Shares issued upon exercise of stock options
|
2019-09-30 |
| 2019-08-07 | 4641.77 | 未披露 | 定期报告 | 2019-08-02 |
| 2019-07-29 | 4507.50 | 未披露 | 定期报告 | 2019-07-29 |
| 2019-08-07 | 4002.79 | 未披露 |
更多>>
From March 31, 2019 to June 30, 2019
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
|
2019-06-30 |
| 2019-05-07 | 3975.16 | 未披露 | 定期报告 | 2019-05-02 |
| 2019-04-24 | 3973.88 | 未披露 | 定期报告 | 2019-04-17 |
| 2019-05-07 | 3957.50 | 未披露 |
更多>>
from December 31, 2018 to March 31, 2019
Shares issued upon exercise of stock options
Shares issued for consulting services
|
2019-03-31 |
| 2019-03-12 | 3954.76 | 未披露 |
更多>>
from December 31, 2017 to December 31, 2018
Sale of common stock under license agreement
Sale of common stock in a follow-on public offering ($19.00 per share), net of underwriting discounts and commissions and offering expenses of $6,262
Shares issued upon vesting of performance-based restricted stock units
Shares issued upon exercise of stock options
|
2018-12-31 |
| 2018-11-06 | 3944.68 | 未披露 | 定期报告 | 2018-11-01 |
| 2018-11-06 | 3938.95 | 未披露 |
更多>>
from December 31, 2017 to September 30, 2018
Sale of common stock under license agreement
Sale of common stock in a follow-on public offering ($19.00 per share), net of underwriting discounts and commissions and offering expenses of $6,248
Shares issued upon exercise of stock options
|
2018-09-30 |
| 2018-08-07 | 3929.05 | 未披露 | 定期报告 | 2018-08-01 |
| 2018-08-07 | 3405.92 | 未披露 |
更多>>
From December 31, 2017 to June 30, 2018
Sale of common stock under license agreement
Shares issued upon exercise of stock options
|
2018-06-30 |
| 2018-05-09 | 3269.99 | 未披露 |
更多>>
From December 31, 2017 to March 31, 2018
Shares issued upon exercise of stock options
|
2018-03-31 |
| 2018-03-15 | 3269.02 | 未披露 | 定期报告 | 2018-03-08 |
| 2018-03-15 | 3266.23 | 未披露 |
更多>>
from December 31, 2016 to December 31, 2017
Sale of common stock in a follow-on public offering ($18.00 per share), net of underwriting discounts and commissions and offering expenses of $5,891
Shares issued upon exercise of stock options
|
2017-12-31 |
| 2017-11-02 | 3260.85 | 未披露 |
更多>>
from December 31, 2016 to September 30, 2017
Sale of common stock in a follow-on public offering ($18.00 per share), net of underwriting discounts and commissions and offering expenses of $5,891
Shares issued upon exercise of stock options
|
2017-09-30 |
| 2017-08-03 | 3258.15 | 未披露 | 定期报告 | 2017-07-28 |
| 2017-08-03 | 3256.75 | 未披露 |
更多>>
from December 31, 2016 to June 30, 2017
Sale of common stock in a follow-on public offering ($18.00 per share), net of underwriting discounts and commissions and offering expenses of $5,891
Shares issued upon exercise of stock options
|
2017-06-30 |
| 2017-05-04 | 3250.75 | 未披露 | 定期报告 | 2017-04-28 |
| 2017-05-04 | 2732.42 | 未披露 |
更多>>
from December 31, 2016 to March 31, 2017
Shares issued upon exercise of stock options
|
2017-03-31 |
| 2017-03-10 | 2730.33 | 未披露 | 定期报告 | 2017-03-03 |
| 2017-03-10 | 2729.69 | 未披露 |
更多>>
From December 31, 2015 to December 31, 2016
Shares issued upon exercise of stock options
|
2016-12-31 |
| 2016-05-05 | 2728.29 | 未披露 |
更多>>
From December 31, 2015 to March 31, 2016
Shares issued upon exercise of stock options
|
2016-03-31 |
| 2016-03-11 | 2725.49 | 未披露 |
更多>>
from December 31, 2014 to December 31, 2015
Sale of common stock in a follow-on public offering ($18.60 per share), net of underwriting discounts and commissions and offering expenses of $5,269
Shares issued upon exercise of stock options
|
2015-12-31 |
| 2015-11-09 | 2723.16 | 未披露 |
更多>>
from December 31, 2014 to September 30, 2015
Sale of common stock in a follow-on public offering ($18.60 per share), net of underwriting discounts and commissions and offering expenses of $5,269
Shares issued upon exercise of stock options
|
2015-09-30 |
| 2015-08-10 | 2716.49 | 未披露 | 定期报告 | 2015-08-05 |
| 2015-08-10 | 2283.69 | 未披露 |
更多>>
from December 31, 2014 to June 30, 2015
Shares issued upon exercise of stock options
|
2015-06-30 |
| 2015-05-12 | 2282.49 | 未披露 |
更多>>
from December 31, 2014 to March 31, 2015
Shares issued upon exercise of stock options
|
2015-03-31 |
| 2015-03-27 | 2282.49 | 未披露 | 定期报告 | 2015-03-20 |
| 2015-03-27 | 2280.20 | 未披露 |
更多>>
from December 31, 2013 to December 31, 2014
Preferred stock converted to common shares
Sale of common stock in initial public offering ($11.00 per share), net of underwriting discounts and commissions and offering expenses of $6,953
Sale of common stock in a private placement ($8.74 per share)
Shares issued upon exercise of stock options
Shares issued upon cashless exercise of warrants
|
2014-12-31 |
| 2014-11-10 | 2277.86 | 未披露 |
更多>>
from December 31, 2013 to September 30, 2014
Preferred stock converted to common shares
Sale of common stock in initial public offering ($11.00 per share), net of underwriting discounts and commissions and offering expenses of $7,003
Shares issued upon exercise of stock options
Shares issued upon cashless exercise of warrants
The Company’s Board of Directors and stockholders approved a 1-for-2.5 reverse stock split of the Company’s common stock effective on January 16, 2014
|
2014-09-30 |
| 2014-08-07 | 2264.48 | 未披露 | 定期报告 | 2014-08-05 |
| 2014-08-07 | 2263.84 | 未披露 |
更多>>
From December 31, 2013 to June 30, 2014
Sale of common stock in initial public offering ($11.00 per share), net of underwriting discounts and commissions and offering expenses of $7,003
Preferred stock converted to common shares
Shares issued upon exercise of stock options
The Company’s Board of Directors and stockholders approved a 1-for-2.5 reverse stock split of the Company’s common stock effective on January 16, 2014
|
2014-06-30 |
| 2014-05-12 | 2260.20 | 未披露 | 定期报告 | 2014-05-05 |
| 2014-05-12 | 2259.24 | 未披露 |
更多>>
from December 31, 2013 to March 31, 2014
Preferred stock converted to common shares
Sale of common stock in initial public offering ($11.00 per share), net of underwriting discounts and commissions and offering expenses of $7,003
|
2014-03-31 |
| 2014-03-28 | 2259.24 | 未披露 |
更多>>
Upon the closing of the Company’s IPO on February 5, 2014, all outstanding shares of the Company’s Preferred Stock were automatically converted into an aggregate of 12,554,188 shares of its common stock.
|
2014-03-21 |
| 2014-02-03 | 2184.24 | 未披露 |
更多>>
a 1-for-2.5 reverse stock split of our common stock effected on January 16, 2014;the conversion of all outstanding shares of our preferred stock into an aggregate of 12,554,188 shares of our common stock, which will occur automatically upon the closing of this offering, which we refer to as the automatic preferred stock conversion
|
2014-01-31 |
| 2014-03-28 | 428.82 | 2918.69 |
更多>>
from December 31,2012 to January 17, 2014
Preferred stock converted to common shares
Issuance of Junior A convertible preferred stock
Convertible promissory notes converted to Series D preferred stock
A 1-for-2.5 reverse stock split of the Company’s common stock effective on January 16, 2014
|
2014-01-17 |
| 2013-11-08 | 1072.06 | 2918.69 |
更多>>
from December 31, 2012 to September 30, 2013
Preferred stock converted to common shares
Issuance of Junior A convertible preferred stock
Convertible promissory notes converted to Series D convertible preferred stock
|
2013-09-30 |
From December 31,2022 to December 31,2023
Net proceeds from sales of common stock under open market sales agreement
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
From June 30, 2023 to September 30, 2023
Net proceeds from sales of common stock under open market sales agreement
Shares issued upon vesting of restricted stock units
From March 31, 2023 to June 30, 2023
Shares issued upon vesting of restricted stock units
From December 31, 2022 to March 31, 2023
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
From December 31, 2021 to December 31, 2022
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
From June 30, 2022 to September 30, 2022
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
From December 31, 2021 to March 31, 2022
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
From December 31, 2020 to December 31, 2021
Sale of common stock under license agreement with Vifor ($15.23 per share)
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
From June 30, 2021 to September 30, 2021
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
From March 31, 2021 to June 30, 2021
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
From December 31, 2020 to March 31, 2021
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
From December 31,2019 to December 31,2020
Sale of common stock under license agreement
Shares issued upon vesting of restricted stock units
Shares issued upon exercise of stock options
From June 30, 2020 to September 30, 2020
Shares issued upon exercise of stock options
From March 31, 2020 to June 30, 2020
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
From December 31, 2019 to March 31, 2020
Shares issued upon exercise of stock options
from December 31, 2018 to December 31, 2019
Sale of common stock in a follow-on public offering ($23.00 per share), net of underwriting discounts and commissions and offering expenses of $8,977
Issuance of common stock upon entry into License Agreement with Enteris Biopharma, Inc. ($23.42 per share)
Shares issued upon exercise of stock options
Shares issued upon vesting of executive restricted stock units
Shares issued for consulting services
from June 30, 2019 to September 30, 2019
Sale of common stock in a follow-on public offering ($23.00 per share), net of underwriting discounts and commissions and offering expenses of $8,950
Issuance of common stock upon entry into License Agreement with Enteris Biopharma, Inc. ($23.42 per share)
Shares issued upon exercise of stock options
From March 31, 2019 to June 30, 2019
Shares issued upon exercise of stock options
Shares issued upon vesting of restricted stock units
from December 31, 2018 to March 31, 2019
Shares issued upon exercise of stock options
Shares issued for consulting services
from December 31, 2017 to December 31, 2018
Sale of common stock under license agreement
Sale of common stock in a follow-on public offering ($19.00 per share), net of underwriting discounts and commissions and offering expenses of $6,262
Shares issued upon vesting of performance-based restricted stock units
Shares issued upon exercise of stock options
from December 31, 2017 to September 30, 2018
Sale of common stock under license agreement
Sale of common stock in a follow-on public offering ($19.00 per share), net of underwriting discounts and commissions and offering expenses of $6,248
Shares issued upon exercise of stock options
From December 31, 2017 to June 30, 2018
Sale of common stock under license agreement
Shares issued upon exercise of stock options
From December 31, 2017 to March 31, 2018
Shares issued upon exercise of stock options
from December 31, 2016 to December 31, 2017
Sale of common stock in a follow-on public offering ($18.00 per share), net of underwriting discounts and commissions and offering expenses of $5,891
Shares issued upon exercise of stock options
from December 31, 2016 to September 30, 2017
Sale of common stock in a follow-on public offering ($18.00 per share), net of underwriting discounts and commissions and offering expenses of $5,891
Shares issued upon exercise of stock options
from December 31, 2016 to June 30, 2017
Sale of common stock in a follow-on public offering ($18.00 per share), net of underwriting discounts and commissions and offering expenses of $5,891
Shares issued upon exercise of stock options
from December 31, 2016 to March 31, 2017
Shares issued upon exercise of stock options
From December 31, 2015 to December 31, 2016
Shares issued upon exercise of stock options
From December 31, 2015 to March 31, 2016
Shares issued upon exercise of stock options
from December 31, 2014 to December 31, 2015
Sale of common stock in a follow-on public offering ($18.60 per share), net of underwriting discounts and commissions and offering expenses of $5,269
Shares issued upon exercise of stock options
from December 31, 2014 to September 30, 2015
Sale of common stock in a follow-on public offering ($18.60 per share), net of underwriting discounts and commissions and offering expenses of $5,269
Shares issued upon exercise of stock options
from December 31, 2014 to June 30, 2015
Shares issued upon exercise of stock options
from December 31, 2014 to March 31, 2015
Shares issued upon exercise of stock options
from December 31, 2013 to December 31, 2014
Preferred stock converted to common shares
Sale of common stock in initial public offering ($11.00 per share), net of underwriting discounts and commissions and offering expenses of $6,953
Sale of common stock in a private placement ($8.74 per share)
Shares issued upon exercise of stock options
Shares issued upon cashless exercise of warrants
from December 31, 2013 to September 30, 2014
Preferred stock converted to common shares
Sale of common stock in initial public offering ($11.00 per share), net of underwriting discounts and commissions and offering expenses of $7,003
Shares issued upon exercise of stock options
Shares issued upon cashless exercise of warrants
The Company’s Board of Directors and stockholders approved a 1-for-2.5 reverse stock split of the Company’s common stock effective on January 16, 2014
From December 31, 2013 to June 30, 2014
Sale of common stock in initial public offering ($11.00 per share), net of underwriting discounts and commissions and offering expenses of $7,003
Preferred stock converted to common shares
Shares issued upon exercise of stock options
The Company’s Board of Directors and stockholders approved a 1-for-2.5 reverse stock split of the Company’s common stock effective on January 16, 2014
from December 31, 2013 to March 31, 2014
Preferred stock converted to common shares
Sale of common stock in initial public offering ($11.00 per share), net of underwriting discounts and commissions and offering expenses of $7,003
Upon the closing of the Company’s IPO on February 5, 2014, all outstanding shares of the Company’s Preferred Stock were automatically converted into an aggregate of 12,554,188 shares of its common stock.
a 1-for-2.5 reverse stock split of our common stock effected on January 16, 2014;the conversion of all outstanding shares of our preferred stock into an aggregate of 12,554,188 shares of our common stock, which will occur automatically upon the closing of this offering, which we refer to as the automatic preferred stock conversion
from December 31,2012 to January 17, 2014
Preferred stock converted to common shares
Issuance of Junior A convertible preferred stock
Convertible promissory notes converted to Series D preferred stock
A 1-for-2.5 reverse stock split of the Company’s common stock effective on January 16, 2014
from December 31, 2012 to September 30, 2013
Preferred stock converted to common shares
Issuance of Junior A convertible preferred stock
Convertible promissory notes converted to Series D convertible preferred stock