CORI

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From September 30, 2017 to June 30, 2018 Issuance of common stock under Employee Stock Purchase Plan Issuance of common stock upon exercise of stock options Issuance of common stock upon net exercise of common stock warrants

From September 30, 2017 to March 31, 2018 Issuance of common stock under Employee Stock Purchase Plan Issuance of common stock upon exercise of stock options Issuance of common stock upon net exercise of common stock warrants

From September 30, 2017 To December 31, 2017 Issuance of common stock under Employee Stock Purchase Plan Issuance of common stock upon exercise of stock options

From September 30, 2016 To September 30, 2017 Issuance of common stock in connection with February 2017 public offering, net of issuance costs Issuance of common stock in connection with May 2017 public offering, net of issuance costs Issuance of common stock under Employee Stock Purchase Plan Issuance of common stock upon exercise of stock options Restricted stock units vested and released

From September 30, 2016 to June 30, 2017 Issuance of common stock in connection with February 2017 public offering, net of issuance costs Issuance of common stock in connection with May 2017 public offering, net of issuance costs Issuance of common stock under Employee Stock Purchase Plan Issuance of common stock upon exercise of stock options Restricted stock units vested and released

from September 30, 2016 to March 31, 2017 Issuance of common stock in connection with public offering, net of issuance costs Issuance of common stock under Employee Stock Purchase Plan Issuance of common stock upon exercise of stock options Restricted stock units vested and released

From September 30, 2016 to December 31, 2016 Issuance of common stock under Employee Stock Purchase Plan Issuance of common stock upon exercise of stock options

from September 30, 2015 to September 30, 2016 Issuance of common stock under Employee Stock Purchase Plan Issuance of common stock upon exercise of stock options

from September 30, 2015 to June 30, 2016 Issuance of common stock under Employee Stock Purchase Plan Issuance of common stock upon exercise of stock options

from September 30, 2015 to March 31, 2016 Issuance of common stock under Employee Stock Purchase Plan Issuance of common stock upon exercise of stock options

from September 30, 2015 to December 31, 2015 Issuance of common stock under Employee Stock Purchase Plan Issuance of common stock upon exercise of stock options

from September 30, 2014 to September 30, 2015 Issuance of common stock in connection with public offering, net of issuance costs Issuance of common stock under Employee Stock Purchase Plan Issuance of common stock upon exercise of stock options Issuance of common stock upon net exercise of common stock warrants Issuance of common stock upon exercise of common stock warrants

from September 30, 2014 to June 30, 2015 Issuance of common stock under Employee Stock Purchase Plan Issuance of common stock upon exercise of stock options Issuance of common stock upon net exercise of common stock warrants Issuance of common stock upon exercise of common stock warrants

From September 30, 2014 to March 31, 2015 Issuance of common stock under Employee Stock Purchase Plan Issuance of common stock upon exercise of stock options

From September 30, 2013 to September 30, 2014 Issuance of common stock in connection with initial public offering, net of issuance costs of $2.70 million Conversion of convertible preferred stock to common stock in connection with initial public offering Issuance of common stock in connection with conversion of convertible debt Issuance of common stock upon conversion of subordinated debt in connection with the recapitalization transaction Issuance of common stock upon net exercise of preferred stock warrants and related extinguishment of preferred stock warrant liability Issuance of common stock upon net exercise of common stock warrants Repurchase of redeemable common stock and common stock from founders in connection with initial public offering Issuance of common stock upon exercise of stock options Aggregate fractional shares cancelled in connection with reverse stock split

From September 30, 2013 to June 30, 2014 Issuance of common stock in connection with initial public offering, net of issuance costs of $2.70 million Conversion of convertible preferred stock to common stock in connection with initial public offering Issuance of common stock in connection with conversion of convertible debt Issuance of common stock upon conversion of subordinated debt in connection with the recapitalization transaction Issuance of common stock upon net exercise of preferred stock warrants and related extinguishment of preferred stock warrant liability Issuance of common stock upon net exercise of common stock warrants Repurchase of redeemable common stock and common stock from founders in connection with initial public offering Issuance of common stock upon exercise of stock options Aggregate fractional shares cancelled in connection with reverse stock split

A 10.1-for-one reverse stock split of our outstanding common stock that was effected on March 21, 2014 The conversion of all outstanding shares of our convertible preferred stock into an aggregate of 3,567,807 shares of common stock immediately prior to the closing of this offering

from December 31, 2013 to March 31, 2014 Issuance of common stock upon exercise of stock options Aggregate fractional shares cancelled in connection with reverse stock split

from September 30, 2013 to March 24, 2014 Issuance of common stock upon exercise of stock options Effect a 10.1-to-1 reverse stock split of our outstanding common stock (the "reverse stock split"),The reverse stock split became effective on March 21, 2014.

from September 30, 2013 to December 31, 2013 Issuance of common stock upon exercise of stock options