股本结构
单位：万股
| 公告日期 | 2024-04-05 | 2024-03-14 | 2024-03-14 | 2023-11-09 | 2023-08-09 | 2023-05-09 |
|---|---|---|---|---|---|---|
| 证券总股本 | 6794.08 | 6775.00 | 6328.64 | 5856.01 | 5704.62 | 5429.18 |
| 普通股本 | 6794.08 | 6775.00 | 6328.64 | 5856.01 | 5704.62 | 5429.18 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2024-03-25 | 2024-03-13 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-05-05 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2024-04-05 | 6794.08 | 未披露 | 定期报告 | 2024-03-25 |
| 2024-03-14 | 6775.00 | 未披露 | 定期报告 | 2024-03-13 |
| 2024-03-14 | 6328.64 | 未披露 |
更多>>
From December 31, 2022 to December 31, 2023
Issuance of common stock from at-the-market offerings, net of offering costs
Issuance of common stock upon release of restricted stock units
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from underwritten follow-on offering, net of offering costs
|
2023-12-31 |
| 2023-11-09 | 5856.01 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Issuance of common stock from at-the-market offerings, net of offering costs
|
2023-09-30 |
| 2023-08-09 | 5704.62 | 未披露 |
更多>>
From March 31, 2023 to June 30, 2023
Issuance of common stock upon release of restricted stock units
Issuance of common stock from at-the-market offerings, net of offering costs
Issuance of common stock pursuant to employee stock purchase plan
|
2023-06-30 |
| 2023-05-09 | 5429.18 | 未披露 | 定期报告 | 2023-05-05 |
| 2023-05-09 | 5333.96 | 未披露 |
更多>>
From December 31, 2022 to March 31, 2023
Issuance of common stock upon release of restricted stock units
Issuance of common stock from at-the-market offerings, net of offering costs
Issuance of common stock from underwritten follow-on public offering, net of offering costs
|
2023-03-31 |
| 2023-03-14 | 5316.21 | 未披露 | 定期报告 | 2023-03-10 |
| 2023-02-09 | 5123.44 | 未披露 |
更多>>
Common stock offered 22,225,000 shares by the company
|
2023-02-13 |
| 2023-03-14 | 2949.85 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Issuance of common stock upon release of restricted stock units
Issuance of common stock upon exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from at-the-market offerings, net of offering costs
|
2022-12-31 |
| 2022-11-14 | 2900.94 | 未披露 |
更多>>
From June 30, 2022 to September 30, 2022
Issuance of common stock from at-the-market offerings, net of offering costs
|
2022-09-30 |
| 2022-08-15 | 2862.50 | 未披露 | 定期报告 | 2022-08-12 |
| 2022-08-15 | 2812.75 | 未披露 |
更多>>
From March 31,2022 to June 30,2022
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from at-the-market offerings, net of offering costs
|
2022-06-30 |
| 2022-05-10 | 2805.62 | 未披露 |
更多>>
From December 31, 2021 to March 31, 2022
Issuance of common stock upon release of restricted stock units
Issuance of common stock upon exercise of stock options
Issuance of common stock from at-the-market offerings, net of offering costs
|
2022-03-31 |
| 2022-03-15 | 2779.58 | 未披露 | 定期报告 | 2022-03-10 |
| 2022-03-15 | 2779.30 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Issuance of common stock upon release of restricted stock units
Issuance of common stock upon exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from at-the-market offerings, net of offering costs
Issuance of common stock from committed purchase agreement, net of offering costs
Issuance of common stock from underwritten follow-on offering, net of offering costs
|
2021-12-31 |
| 2021-11-12 | 2779.07 | 未披露 |
更多>>
From June 30, 2021 to September 30, 2021
Issuance of common stock upon exercise of stock options
Issuance of common stock from at-the-market offerings, net of offering costs
Issuance of common stock from underwritten follow-on offering, net of offering costs
|
2021-09-30 |
| 2021-09-20 | 2708.86 | 未披露 |
更多>>
1.Common stock offered 9,375,000 shares.
2.The number of shares of common stock to be outstanding after this offering is based on 16,307,370 shares of common stock outstanding as of June 30, 2021
|
2021-09-20 |
| 2021-08-10 | 1691.99 | 未披露 | 定期报告 | 2021-08-09 |
| 2021-08-11 | 1630.74 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Issuance of common stock upon exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from at the market offerings, net of offering costs
|
2021-06-30 |
| 2021-05-14 | 1606.46 | 未披露 | 定期报告 | 2021-05-07 |
| 2021-05-14 | 1601.14 | 未披露 |
更多>>
from December 31, 2020 to March 31, 2021
Issuance of common stock upon release of restricted stock units
Issuance of common stock from at the market offerings, net of offering costs
Issuance of common stock from committed purchase agreement, net of offering costs
|
2021-03-31 |
| 2021-03-24 | 1601.14 | 未披露 | 定期报告 | 2021-03-19 |
| 2021-03-24 | 1101.90 | 未披露 |
更多>>
from December 31, 2019 to December 31, 2020
Conversion of preferred stock to common stock
Issuance of common stock from underwritten follow-on offering, net of offering costs
Issuance of common stock from at the market offerings, net of offering costs
Issuance of common stock upon release of restricted stock units
Issuance of common stock pursuant to employee stock purchase plan
|
2020-12-31 |
| 2020-11-16 | 1018.55 | 未披露 | 定期报告 | 2020-11-12 |
| 2020-11-13 | 1012.40 | 未披露 | 定期报告 | 2020-11-06 |
| 2020-10-02 | 1000.78 | 未披露 | 定期报告 | 2020-10-01 |
| 2020-11-13 | 999.10 | 未披露 |
更多>>
From June 30, 2020 to September 30, 2020
Issuance of common stock from at the market offerings, net of offering costs
|
2020-09-30 |
| 2020-09-18 | 994.23 | 未披露 | 定期报告 | 2020-09-11 |
| 2020-08-13 | 953.69 | 未披露 | 定期报告 | 2020-08-07 |
| 2020-08-13 | 938.34 | 未披露 |
更多>>
From March 31, 2020 to June 30, 2020
Issuance of common stock upon release of restricted stock units
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from at the market offerings, net of offering costs
|
2020-06-30 |
| 2020-05-12 | 935.25 | 未披露 |
更多>>
From December 31, 2019 to March 31, 2020
Conversion of preferred stock to common stock
Issuance of common stock upon release of restricted stock units
Issuance of common stock from underwritten follow-on offering, net of offering costs
|
2020-03-31 |
| 2020-04-02 | 935.25 | 未披露 | 定期报告 | 2020-03-16 |
| 2020-02-10 | 812.55 | 未披露 |
更多>>
1.Common stock to be offered by us 4,235,294 shares
2.Except as otherwise indicated herein, the number of shares of common stock to be outstanding after this offering is based on 3,890,185 shares of common stock outstanding as of September 30, 2019
|
2020-02-10 |
| 2020-01-17 | 430.00 | 未披露 | 定期报告 | 2020-01-10 |
| 2020-03-26 | 389.18 | 164.40 |
更多>>
From December 31, 2018 to December 31, 2019
Conversion of preferred stock to common stock
Issuance of common stock upon release of restricted stock units
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from at the market offerings, net of offering costs
Issuance of common stock from registered direct offering, net of offering costs
|
2019-12-31 |
| 2019-11-14 | 389.02 | 164.40 |
更多>>
From June 30, 2019 to September 30, 2019
Issuance of common stock from at the market offerings, net of offering costs
|
2019-09-30 |
| 2019-08-14 | 389.02 | 未披露 | 定期报告 | 2019-08-07 |
| 2019-08-14 | 353.14 | 164.40 |
更多>>
from March 31, 2019 to July 1, 2019
Issuance of common stock upon release of restricted stock units
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from at the market offerings, net of offering costs
Issuance of common stock from registered direct offering, net
The reverse stock split will reduce the number of shares of common stock issued and outstanding from approximately 49.4 million to approximately 3.5 million. The number of shares of common stock issuable upon conversion of the outstanding shares of the company's preferred stock will be reduced from 8.2 million shares to 0.6 million shares. In addition, the number of authorized shares of common stock will be reduced from 150.0 million to 10.7 million.
|
2019-07-01 |
| 2019-06-18 | 4721.44 | 164.40 | 定期报告 | 2019-06-17 |
| 2019-05-22 | 4586.84 | 164.40 | 定期报告 | 2019-05-20 |
| 2019-04-12 | 4574.23 | 未披露 | 定期报告 | 2019-04-12 |
| 2019-05-14 | 3650.02 | 164.40 |
更多>>
from December 31, 2018 to March 31, 2019
Conversion of preferred stock to common stock
Issuance of common stock from at the market offerings, net of offering costs
|
2019-03-31 |
| 2019-03-26 | 3476.71 | 未披露 | 定期报告 | 2019-03-15 |
| 2019-03-28 | 3389.68 | 未披露 | 定期报告 | 2019-01-30 |
| 2019-03-26 | 3057.91 | 228.60 |
更多>>
from December 31, 2017 to December 31, 2018
Exercise of common stock options and release of restricted stock units
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from at the market offerings, net of offering costs
|
2018-12-31 |
| 2018-11-14 | 3002.35 | 未披露 | 定期报告 | 2018-11-08 |
| 2018-11-14 | 2986.55 | 228.60 | 定期报告 | 2018-09-30 |
| 2018-08-14 | 2985.70 | 228.60 | 定期报告 | 2018-06-30 |
| 2018-05-15 | 2982.87 | 228.60 | 定期报告 | 2018-03-31 |
| 2018-04-03 | 2979.77 | 未披露 | 定期报告 | 2018-03-15 |
| 2018-03-20 | 2978.92 | 228.60 |
更多>>
from December 31, 2016 to December 31, 2017
Issuance of common stock and preferred stock from private placement, net of offering costs
Exercise of common stock options and release of restricted stock units
Issuance of common stock pursuant to employee stock purchase plan
|
2017-12-31 |
| 2017-11-14 | 2975.83 | 未披露 | 定期报告 | 2017-11-07 |
| 2017-11-14 | 2971.58 | 228.60 | 定期报告 | 2017-09-30 |
| 2017-09-14 | 2971.18 | 未披露 | 定期报告 | 2017-08-31 |
| 2017-08-14 | 2383.90 | 未披露 | 定期报告 | 2017-08-04 |
| 2017-08-14 | 2383.72 | 未披露 | 定期报告 | 2017-06-30 |
| 2017-05-11 | 2380.63 | 未披露 | 定期报告 | 2017-05-10 |
| 2017-05-11 | 2378.10 | 未披露 | 定期报告 | 2017-03-31 |
| 2017-03-30 | 2374.82 | 未披露 | 定期报告 | 2017-03-15 |
| 2017-03-16 | 2374.81 | 未披露 | 定期报告 | 2017-03-08 |
| 2017-03-16 | 2374.48 | 未披露 |
更多>>
From December 31, 2015 to December 31, 2016
Exercise of common stock options
Issuance of common stock pursuant to employee stock purchase plan
|
2016-12-31 |
| 2016-11-14 | 2371.85 | 未披露 | 定期报告 | 2016-09-30 |
| 2016-08-10 | 2371.85 | 未披露 | 定期报告 | 2016-08-05 |
| 2016-08-10 | 2371.77 | 未披露 | 定期报告 | 2016-06-30 |
| 2016-06-13 | 2371.77 | 未披露 | 定期报告 | 2016-06-10 |
| 2016-05-11 | 2368.72 | 未披露 | 定期报告 | 2016-05-06 |
| 2016-05-11 | 2367.73 | 未披露 | 定期报告 | 2016-03-31 |
| 2016-03-30 | 2367.73 | 未披露 | 定期报告 | 2016-03-24 |
| 2016-03-30 | 2367.01 | 未披露 |
更多>>
from December 31, 2014 to December 31, 2015
Issuance of Series E redeemable convertible preferred stock for cash
Conversion of redeemable convertible preferred stock in connection with IPO
Issuance of common stock through initial public offering, net
Exercise of common stock options
Issuance of common stock to The Scripps Research Institute
On May 5, 2015, the company filed an amendment to amended and restated certificate of incorporation to effect a one-for-7.95413 reverse stock split of common stock.
|
2015-12-31 |
| 2015-11-10 | 2364.84 | 未披露 | 定期报告 | 2015-11-06 |
| 2015-08-12 | 2363.93 | 未披露 |
更多>>
In May 2015, we completed our IPO whereby we sold 6,164,000 shares of common stock at a public offering price of $14.00 per share. As a result of the IPO, we raised a total of $75.9 million in net proceeds after deducting underwriting discounts and commissions of approximately $6.0 million and offering expenses of approximately $4.4 million. In addition, in connection with the IPO, all outstanding convertible preferred stock converted into 16,279,859 shares of our common stock.
|
2015-06-30 |
| 2015-06-18 | 2363.45 | 未披露 | 定期报告 | 2015-06-10 |
| 2015-05-07 | 2254.97 | 未披露 |
更多>>
1. the conversion of all of our outstanding shares of redeemable convertible preferred stock, including the shares of our Series E redeemable convertible preferred stock issued in March 2015, into 16,279,859 shares of common stock upon the completion of this offering;
2. a one-for-7.95413 reverse split of our common stock effected on May 5, 2015
|
2015-05-07 |
| 2015-06-18 | 102.97 | 14165.43 | 定期报告 | 2015-03-31 |
| 2015-04-27 | 90.99 | 7348.74 |
更多>>
From December 31, 2013 to December 31, 2014
Exercise of common stock options
|
2014-12-31 |
From December 31, 2022 to December 31, 2023
Issuance of common stock from at-the-market offerings, net of offering costs
Issuance of common stock upon release of restricted stock units
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from underwritten follow-on offering, net of offering costs
From June 30, 2023 to September 30, 2023
Issuance of common stock from at-the-market offerings, net of offering costs
From March 31, 2023 to June 30, 2023
Issuance of common stock upon release of restricted stock units
Issuance of common stock from at-the-market offerings, net of offering costs
Issuance of common stock pursuant to employee stock purchase plan
From December 31, 2022 to March 31, 2023
Issuance of common stock upon release of restricted stock units
Issuance of common stock from at-the-market offerings, net of offering costs
Issuance of common stock from underwritten follow-on public offering, net of offering costs
Common stock offered 22,225,000 shares by the company
From December 31, 2021 to December 31, 2022
Issuance of common stock upon release of restricted stock units
Issuance of common stock upon exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from at-the-market offerings, net of offering costs
From June 30, 2022 to September 30, 2022
Issuance of common stock from at-the-market offerings, net of offering costs
From March 31,2022 to June 30,2022
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from at-the-market offerings, net of offering costs
From December 31, 2021 to March 31, 2022
Issuance of common stock upon release of restricted stock units
Issuance of common stock upon exercise of stock options
Issuance of common stock from at-the-market offerings, net of offering costs
From December 31, 2020 to December 31, 2021
Issuance of common stock upon release of restricted stock units
Issuance of common stock upon exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from at-the-market offerings, net of offering costs
Issuance of common stock from committed purchase agreement, net of offering costs
Issuance of common stock from underwritten follow-on offering, net of offering costs
From June 30, 2021 to September 30, 2021
Issuance of common stock upon exercise of stock options
Issuance of common stock from at-the-market offerings, net of offering costs
Issuance of common stock from underwritten follow-on offering, net of offering costs
1.Common stock offered 9,375,000 shares.
2.The number of shares of common stock to be outstanding after this offering is based on 16,307,370 shares of common stock outstanding as of June 30, 2021
From March 31, 2021 to June 30, 2021
Issuance of common stock upon exercise of stock options
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from at the market offerings, net of offering costs
from December 31, 2020 to March 31, 2021
Issuance of common stock upon release of restricted stock units
Issuance of common stock from at the market offerings, net of offering costs
Issuance of common stock from committed purchase agreement, net of offering costs
from December 31, 2019 to December 31, 2020
Conversion of preferred stock to common stock
Issuance of common stock from underwritten follow-on offering, net of offering costs
Issuance of common stock from at the market offerings, net of offering costs
Issuance of common stock upon release of restricted stock units
Issuance of common stock pursuant to employee stock purchase plan
From June 30, 2020 to September 30, 2020
Issuance of common stock from at the market offerings, net of offering costs
From March 31, 2020 to June 30, 2020
Issuance of common stock upon release of restricted stock units
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from at the market offerings, net of offering costs
From December 31, 2019 to March 31, 2020
Conversion of preferred stock to common stock
Issuance of common stock upon release of restricted stock units
Issuance of common stock from underwritten follow-on offering, net of offering costs
1.Common stock to be offered by us 4,235,294 shares
2.Except as otherwise indicated herein, the number of shares of common stock to be outstanding after this offering is based on 3,890,185 shares of common stock outstanding as of September 30, 2019
From December 31, 2018 to December 31, 2019
Conversion of preferred stock to common stock
Issuance of common stock upon release of restricted stock units
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from at the market offerings, net of offering costs
Issuance of common stock from registered direct offering, net of offering costs
From June 30, 2019 to September 30, 2019
Issuance of common stock from at the market offerings, net of offering costs
from March 31, 2019 to July 1, 2019
Issuance of common stock upon release of restricted stock units
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from at the market offerings, net of offering costs
Issuance of common stock from registered direct offering, net
The reverse stock split will reduce the number of shares of common stock issued and outstanding from approximately 49.4 million to approximately 3.5 million. The number of shares of common stock issuable upon conversion of the outstanding shares of the company's preferred stock will be reduced from 8.2 million shares to 0.6 million shares. In addition, the number of authorized shares of common stock will be reduced from 150.0 million to 10.7 million.
from December 31, 2018 to March 31, 2019
Conversion of preferred stock to common stock
Issuance of common stock from at the market offerings, net of offering costs
from December 31, 2017 to December 31, 2018
Exercise of common stock options and release of restricted stock units
Issuance of common stock pursuant to employee stock purchase plan
Issuance of common stock from at the market offerings, net of offering costs
from December 31, 2016 to December 31, 2017
Issuance of common stock and preferred stock from private placement, net of offering costs
Exercise of common stock options and release of restricted stock units
Issuance of common stock pursuant to employee stock purchase plan
From December 31, 2015 to December 31, 2016
Exercise of common stock options
Issuance of common stock pursuant to employee stock purchase plan
from December 31, 2014 to December 31, 2015
Issuance of Series E redeemable convertible preferred stock for cash
Conversion of redeemable convertible preferred stock in connection with IPO
Issuance of common stock through initial public offering, net
Exercise of common stock options
Issuance of common stock to The Scripps Research Institute
On May 5, 2015, the company filed an amendment to amended and restated certificate of incorporation to effect a one-for-7.95413 reverse stock split of common stock.
In May 2015, we completed our IPO whereby we sold 6,164,000 shares of common stock at a public offering price of $14.00 per share. As a result of the IPO, we raised a total of $75.9 million in net proceeds after deducting underwriting discounts and commissions of approximately $6.0 million and offering expenses of approximately $4.4 million. In addition, in connection with the IPO, all outstanding convertible preferred stock converted into 16,279,859 shares of our common stock.
1. the conversion of all of our outstanding shares of redeemable convertible preferred stock, including the shares of our Series E redeemable convertible preferred stock issued in March 2015, into 16,279,859 shares of common stock upon the completion of this offering;
2. a one-for-7.95413 reverse split of our common stock effected on May 5, 2015
From December 31, 2013 to December 31, 2014
Exercise of common stock options