股本结构
单位：万股
| 公告日期 | 2024-05-07 | 2024-04-26 | 2024-04-05 | 2024-03-14 | 2024-02-26 | 2024-03-14 |
|---|---|---|---|---|---|---|
| 证券总股本 | 2099.93 | 2099.45 | 2094.60 | 41892.01 | 39937.05 | 39437.32 |
| 普通股本 | 2099.93 | 2099.45 | 2094.60 | 41892.01 | 39937.05 | 39437.32 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2024-05-03 | 2024-04-17 | 2024-04-12 | 2024-03-08 | 2024-02-21 | 2023-12-31 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2024-05-07 | 2099.93 | 未披露 | 定期报告 | 2024-05-03 |
| 2024-04-26 | 2099.45 | 未披露 | 定期报告 | 2024-04-17 |
| 2024-04-05 | 2094.60 | 未披露 |
更多>>
one-for-twenty reverse stock split of its issued and outstanding common stock
|
2024-04-12 |
| 2024-03-14 | 41892.01 | 未披露 | 定期报告 | 2024-03-08 |
| 2024-02-26 | 39937.05 | 未披露 | 定期报告 | 2024-02-21 |
| 2024-02-26 | 39924.63 | 未披露 | 定期报告 | 2024-02-09 |
| 2024-03-14 | 39437.32 | 3.16 |
更多>>
From December 31,2022 to December 31,2023
Shares sold at the market
Payment of CEO payroll in shares
Issuance of director deferred shares
Issuance of shares for services
Vesting of nonvested shares
Exercise of stock options and employee share purchases
Issuance of shares for employee bonus
Retirement of treasury shares
|
2023-12-31 |
| 2023-11-09 | 38149.55 | 未披露 | 定期报告 | 2023-11-03 |
| 2023-11-09 | 38138.18 | 3.16 |
更多>>
From June 30, 2023 to September 30, 2023
Vesting of nonvested shares
Employee share purchases
Shares sold at the market
Issuance of shares for services
Payment of CEO payroll in shares
|
2023-09-30 |
| 2023-08-08 | 37957.22 | 未披露 | 定期报告 | 2023-08-04 |
| 2023-08-08 | 36749.11 | 3.16 |
更多>>
From March 31, 2023 to June 30, 2023
Retirement of treasury shares
Issuance of shares for employee bonus
Shares sold at the market
Vesting of nonvested shares
|
2023-06-30 |
| 2023-05-09 | 34887.60 | 未披露 | 定期报告 | 2023-05-05 |
| 2023-04-28 | 34166.25 | 未披露 | 定期报告 | 2023-04-17 |
| 2023-05-09 | 34166.32 | 3.16 |
更多>>
From December 31, 2022 to March 31, 2023
Shares sold at the market
Issuance of director deferred shares
Issuance of shares for services
Vesting of nonvested shares
Exercise of stock options and employee share purchases
Issuance of shares for employee bonus
Retirement of treasury shares
|
2023-03-31 |
| 2023-03-16 | 33251.33 | 未披露 | 定期报告 | 2023-03-15 |
| 2023-03-16 | 30557.34 | 3.16 |
更多>>
From December 31, 2021 to December 31, 2022
Vesting of nonvested shares
Shares sold at the market
Issuance of shares for services
Issuance of director deferred shares
Exercise of stock options and employee share purchases
Issuance of shares for milestone achievement
Issuance of shares for employee bonuses
Retirement of treasury shares
|
2022-12-31 |
| 2022-11-08 | 30481.17 | 未披露 | 定期报告 | 2022-11-04 |
| 2022-11-08 | 29494.81 | 3.16 |
更多>>
From June 30, 2022 to September 30, 2022
Exercise of stock options and employee share purchases
Issuance of shares for services
Vesting of nonvested shares
Shares sold at the market
|
2022-09-30 |
| 2022-08-09 | 28316.29 | 未披露 | 定期报告 | 2022-08-04 |
| 2022-08-09 | 28285.97 | 3.16 |
更多>>
From March 31, 2022 to June 30, 2022
Shares sold at the market
Issuance of shares for milestone achievement
Issuance of shares for services
Exercise of stock options
Issuance of shares for employee bonus
Retirement of treasury shares
|
2022-06-30 |
| 2022-06-22 | 28285.91 | 未披露 | 定期报告 | 2022-06-17 |
| 2022-05-10 | 27099.10 | 未披露 | 定期报告 | 2022-05-06 |
| 2022-04-29 | 27027.36 | 未披露 | 定期报告 | 2022-04-11 |
| 2022-05-10 | 26674.00 | 3.16 |
更多>>
From December 31, 2021 to March 31, 2022
Shares sold at the market
Issuance of director deferred shares
Issuance of shares for services
Vesting of nonvested shares
Exercise of stock options and employee share purchases
Issuance of shares for employee bonus
Retirement of treasury shares
|
2022-03-31 |
| 2022-03-01 | 25715.39 | 未披露 | 定期报告 | 2022-01-31 |
| 2022-03-01 | 25689.79 | 3.16 |
更多>>
From December 31, 2020 to December 31, 2021
Conversion of series C-1 convertible preferred stock
Vesting of nonvested shares
Shares sold at the market
Payment of CEO payroll in shares
Issuance of shares for services
Exercise of stock options and employee share purchases
Issuance of shares for employee bonuses
Retirement of treasury shares
|
2021-12-31 |
| 2021-11-09 | 25683.12 | 未披露 | 定期报告 | 2021-11-05 |
| 2021-11-09 | 24751.18 | 3.16 |
更多>>
From June 30, 2021 to September 30, 2021
Conversion of series C-1 convertible preferred stock
Shares sold at the market
Payment of CEO payroll in shares
Issuance of shares for services
Exercise of stock options and employee share purchases
Vesting of nonvested shares
Issuance of shares for employee bonus
Retirement of treasury shares
|
2021-09-30 |
| 2021-08-09 | 23311.46 | 未披露 | 定期报告 | 2021-08-04 |
| 2021-08-09 | 22526.29 | 4.01 |
更多>>
From March 31, 2021 to June 30, 2021
Shares sold at the market
Payment of CEO payroll in shares
Issuance of shares for services
Conversion of series C-1 convertible preferred stock
Exercise of stock options
Issuance of shares for 2020 employee bonus
Retirement of treasury shares
|
2021-06-30 |
| 2021-04-30 | 22244.10 | 未披露 | 定期报告 | 2021-04-23 |
| 2021-05-07 | 21786.16 | 4.21 |
更多>>
From December 31, 2020 To March 31, 2021
Shares sold at the market
Payment of CEO payroll in shares
Issuance of shares for services
Conversion of series C-1 convertible preferred stock
Exercise of stock options and employee share purchases
|
2021-03-31 |
| 2021-03-16 | 20468.54 | 未披露 | 定期报告 | 2021-03-15 |
| 2021-03-16 | 19609.10 | 4.41 |
更多>>
from December 31, 2019 to December 31, 2020
Vesting of nonvested shares
Shares sold at the market
Shares sold under stock purchase agreement
Issuance of shares for business acquisition
Payment of CEO payroll in shares
Payment of consultants in shares
Exercise of stock options and employee share purchases
|
2020-12-31 |
| 2020-11-09 | 19014.93 | 未披露 | 定期报告 | 2020-11-05 |
| 2020-11-09 | 18915.70 | 4.41 |
更多>>
From June 30, 2020 to September 30, 2020
Shares sold at the market
Shares sold under stock purchase agreement
Payment of CEO payroll in shares
Payment of consultant in shares
Exercise of stock options and employee share purchases
Vesting of nonvested shares
|
2020-09-30 |
| 2020-08-10 | 18344.27 | 未披露 | 定期报告 | 2020-08-03 |
| 2020-08-10 | 17141.75 | 34.58 |
更多>>
From March 31, 2020 to June 30, 2020
Shares sold at the market
Issuance of shares for business acquisition
Payment of CEO payroll in shares
Payment of consultant in shares
Exercise of stock options
Vesting of nonvested shares
|
2020-06-30 |
| 2020-05-11 | 16977.68 | 未披露 | 定期报告 | 2020-05-07 |
| 2020-04-28 | 16738.40 | 未披露 | 定期报告 | 2020-04-24 |
| 2020-05-11 | 16330.43 | 4.41 |
更多>>
From December 31, 2019 to March 31, 2020
Shares sold at the market
Payment of consultant in shares
Exercise of stock options and employee share purchases
|
2020-03-31 |
| 2020-03-16 | 16158.99 | 未披露 | 定期报告 | 2020-03-12 |
| 2020-03-16 | 13781.81 | 4.41 |
更多>>
From December 31, 2018 to December 31, 2019
Conversion of Series C-1 convertible preferred stock
Vesting of nonvested shares
Shares sold under stock purchase agreement
Payment of consultant in shares
Exercise of stock options and employee share purchases
|
2019-12-31 |
| 2019-11-07 | 13736.15 | 未披露 | 定期报告 | 2019-11-01 |
| 2019-11-07 | 13735.74 | 4.41 |
更多>>
from June 30, 2019 to September 30, 2019
Payment of consultant in shares
Exercise of stock options and employee share purchases
Vesting of nonvested shares
|
2019-09-30 |
| 2019-08-09 | 13731.28 | 未披露 | 定期报告 | 2019-08-05 |
| 2019-08-09 | 13725.92 | 4.41 |
更多>>
From March 31, 2019 to June 30, 2019
Conversion of Series C-1 convertible preferred stock
Vesting of nonvested shares
|
2019-06-30 |
| 2019-04-26 | 13425.86 | 未披露 | 定期报告 | 2019-04-24 |
| 2019-05-10 | 13420.60 | 5.01 |
更多>>
from December 31, 2018 to March 31, 2019
Shares sold under stock purchase agreement
Conversion of Series C-1 convertible preferred stock
Payment of consultant in shares
Exercise of stock options and employee share purchases
|
2019-03-31 |
| 2019-03-18 | 13420.54 | 未披露 | 定期报告 | 2019-03-11 |
| 2019-03-18 | 11999.63 | 5.01 |
更多>>
from December 31, 2017 to December 31, 2018
Vesting of nonvested shares
Shares sold at the market
Issuance of Series C-1 convertible preferred stock, net of issuance costs of $122,000
Payment of consultant in shares
Exercise of stock options and employee share purchases
|
2018-12-31 |
| 2018-11-07 | 11998.30 | 未披露 | 定期报告 | 2018-11-02 |
| 2018-11-07 | 11835.27 | 3.16 | 定期报告 | 2018-09-30 |
| 2018-08-09 | 11328.21 | 未披露 | 定期报告 | 2018-08-03 |
| 2018-08-09 | 10170.61 | 3.16 | 定期报告 | 2018-06-30 |
| 2018-04-26 | 10399.91 | 未披露 | 定期报告 | 2018-04-24 |
| 2018-05-10 | 10328.10 | 3.16 | 定期报告 | 2018-03-31 |
| 2018-03-16 | 10255.68 | 未披露 | 定期报告 | 2018-02-28 |
| 2018-01-24 | 10196.53 | 未披露 | 定期报告 | 2018-01-23 |
| 2018-03-16 | 10170.61 | 3.16 |
更多>>
from December 31, 2016 to December 31, 2017
Shares sold under Stock Purchase Agreement
Vesting of nonvested shares
Shares sold at the market
Retirement of treasury shares
Issuance of shares for milestones
Issuance of stock for acquisition of SECANT yeast display technology
Exercise of stock options and employee share purchases
|
2017-12-31 |
| 2017-11-07 | 10018.29 | 未披露 | 定期报告 | 2017-11-02 |
| 2017-11-07 | 9974.33 | 3.16 | 定期报告 | 2017-09-30 |
| 2017-08-07 | 9971.23 | 未披露 | 定期报告 | 2017-07-31 |
| 2017-08-07 | 9960.26 | 3.16 | 定期报告 | 2017-06-30 |
| 2017-05-04 | 9911.89 | 未披露 | 定期报告 | 2017-04-26 |
| 2017-05-04 | 9870.26 | 3.16 | 定期报告 | 2017-03-31 |
| 2017-03-16 | 9832.86 | 未披露 | 定期报告 | 2017-02-28 |
| 2017-03-16 | 8779.49 | 3.16 |
更多>>
from December 31, 2015 to December 31, 2016
Vesting of nonvested shares
Shares sold at the market
Issuance of director shares for compensation
Retirement of treasury shares
Issuance of shares for milestones
Exercise of stock options
Employee share purchases
|
2016-12-31 |
| 2016-11-09 | 8712.62 | 未披露 | 定期报告 | 2016-11-02 |
| 2016-11-09 | 8711.55 | 3.16 | 定期报告 | 2016-09-30 |
| 2016-08-04 | 8699.93 | 未披露 | 定期报告 | 2016-07-29 |
| 2016-08-04 | 8691.24 | 3.16 | 定期报告 | 2016-06-30 |
| 2016-05-09 | 8688.25 | 未披露 | 定期报告 | 2016-05-02 |
| 2016-04-28 | 8652.89 | 未披露 | 定期报告 | 2016-04-18 |
| 2016-05-09 | 8652.96 | 3.16 | 定期报告 | 2016-03-31 |
| 2016-02-26 | 8651.65 | 3.16 | 定期报告 | 2016-01-31 |
| 2016-03-15 | 8639.07 | 3.16 |
更多>>
From December 31, 2014 to December 31, 2015
Shares sold in underwritten public offering
Vesting of nonvested shares
Issuance of stock for acquisition of SECANT yeast display technology
Shares sold under Stock Purchase Agreement
Issuance of shares related to milestone achievement
Issuance of stock in connection with XOMA antibody manufacturing facility acquisition
Issuance of stock in connection with PhosImmune acquisition
Issuance of stock for settlement of contingent royalty obligation
Exercise of stock options
Employee share purchases
|
2015-12-31 |
| 2015-11-04 | 8464.62 | 3.16 | 定期报告 | 2015-09-30 |
| 2015-08-03 | 8430.75 | 未披露 | 定期报告 | 2015-07-24 |
| 2015-08-03 | 8425.75 | 3.16 | 定期报告 | 2015-06-30 |
| 2015-05-01 | 7148.57 | 3.16 | 定期报告 | 2015-04-27 |
| 2015-05-01 | 7083.62 | 3.16 | 定期报告 | 2015-03-31 |
| 2015-03-16 | 7075.99 | 未披露 | 定期报告 | 2015-02-24 |
| 2015-03-16 | 6272.01 | 3.16 |
更多>>
from December 31, 2013 to December 31, 2014
Shares sold at the market
Shares sold in registered direct offering
Vesting of nonvested shares
Issuance of stock for acquisition
Shares issued to CEO in lieu of cash compensation
Shares issued for acquisition liability
Retirement of treasury shares
Retirement of preferred shares
Shares issued to settle convertible notes
Exercise of stock options
Employee share purchases
|
2014-12-31 |
| 2014-10-31 | 6268.45 | 3.16 | 定期报告 | 2014-09-30 |
| 2014-08-01 | 6267.94 | 未披露 | 定期报告 | 2014-07-28 |
| 2014-08-01 | 6265.22 | 3.47 | 定期报告 | 2014-06-30 |
| 2014-05-09 | 6223.64 | 3.47 | 定期报告 | 2014-04-30 |
| 2014-05-09 | 6223.06 | 3.47 | 定期报告 | 2014-03-31 |
| 2014-03-07 | 6217.33 | 未披露 | 定期报告 | 2014-02-24 |
| 2014-03-07 | 3634.77 | 3.47 |
更多>>
from December 31, 2012 to December 31, 2013
Common stock issued to preferred shareholder
Shares sold at the market
Extinguishment of debt
Shares sold in registered direct offering
Vesting of nonvested shares
Shares issued to CEO in lieu of cash compensation
Exercise of stock options
Employee share purchases
|
2013-12-31 |
| 2013-11-08 | 3547.28 | 未披露 | 定期报告 | 2013-11-04 |
| 2013-11-08 | 3522.84 | 3.47 | 定期报告 | 2013-09-30 |
| 2013-08-09 | 2974.25 | 未披露 | 定期报告 | 2013-08-05 |
| 2013-08-09 | 2863.28 | 3.47 | 定期报告 | 2013-06-30 |
| 2013-06-21 | 2830.57 | 3.47 | 定期报告 | 2013-05-31 |
| 2013-05-10 | 2830.50 | 未披露 | 定期报告 | 2013-05-09 |
| 2013-04-23 | 2785.38 | 未披露 | 定期报告 | 2013-04-15 |
| 2013-05-10 | 2530.27 | 3.47 | 定期报告 | 2013-03-31 |
| 2013-03-18 | 2529.98 | 未披露 | 定期报告 | 2013-02-22 |
| 2013-01-07 | 2460.50 | 3.47 | 定期报告 | 2013-01-02 |
| 2013-03-18 | 2460.16 | 3.47 |
更多>>
from December 31, 2011 to December 31, 2012
Shares sold at the market
Vesting of nonvested shares
Shares issued to CEO in lieu of cash compensation
Shares issued to consultants for services
Exercise of stock options
Employee share purchases
Shares issued to director for services
Issuance of director deferred shares
|
2012-12-31 |
| 2012-12-21 | 2460.16 | 未披露 | 定期报告 | 2012-12-17 |
| 2012-11-07 | 2459.42 | 未披露 | 定期报告 | 2012-11-02 |
| 2012-11-07 | 2458.46 | 3.47 | 定期报告 | 2012-09-30 |
| 2012-08-08 | 2446.57 | 未披露 | 定期报告 | 2012-08-03 |
| 2012-08-08 | 2387.50 | 3.47 | 定期报告 | 2012-06-30 |
| 2012-05-09 | 2278.51 | 未披露 | 定期报告 | 2012-05-04 |
| 2012-05-09 | 2274.44 | 3.47 | 定期报告 | 2012-03-31 |
| 2012-03-06 | 2249.27 | 未披露 | 定期报告 | 2012-02-24 |
| 2012-03-06 | 2149.15 | 3.47 |
更多>>
from December 31, 2010 to December 31, 2011
Shares sold at the market
Shares issued in private placements
Vesting of nonvested shares
Shares issued to CEO in lieu of cash compensation
Shares issued to consultants for services
Exercise of stock options
Employee share purchases
Shares issued to director for services
|
2011-12-31 |
| 2011-11-04 | 2145.52 | 未披露 | 定期报告 | 2011-11-02 |
| 2011-11-04 | 2133.68 | 3.47 | 定期报告 | 2011-09-30 |
| 2011-08-05 | 11419.76 | 未披露 | 定期报告 | 2011-08-02 |
| 2011-08-05 | 11406.57 | 3.47 | 定期报告 | 2011-06-30 |
| 2011-05-06 | 11336.09 | 未披露 | 定期报告 | 2011-05-03 |
| 2011-05-06 | 11357.47 | 3.47 | 定期报告 | 2011-03-31 |
| 2011-03-16 | 11265.37 | 未披露 | 定期报告 | 2011-03-01 |
| 2011-03-16 | 11188.58 | 3.47 |
更多>>
Shares issued in private placements
Shares sold at the market
Shares issued to repurchase convertible senior notes
Exercise of stock options
Employee share purchases
Shares issued to consultants for services
Shares issued to CEO in lieu of cash compensation
Vesting of nonvested shares
|
2010-12-31 |
| 2010-11-09 | 9934.28 | 未披露 | 定期报告 | 2010-11-04 |
| 2010-11-09 | 9926.73 | 3.47 | 定期报告 | 2010-09-30 |
| 2010-08-06 | 9880.05 | 未披露 | 定期报告 | 2010-08-03 |
| 2010-08-06 | 9895.34 | 3.47 | 定期报告 | 2010-06-30 |
| 2010-05-07 | 9423.15 | 未披露 | 定期报告 | 2010-05-05 |
| 2010-05-07 | 9145.61 | 3.47 | 定期报告 | 2010-03-31 |
| 2010-03-15 | 9094.86 | 未披露 | 定期报告 | 2010-03-01 |
| 2010-03-15 | 8975.45 | 3.47 |
更多>>
from December 31, 2008 to December 31, 2009
Conversion of series B2 preferred shares
Shares issued in private placements
Shares issued to repurchase convertible senior notes
Exercise of stock options
Employee share purchases
Shares issued under Directors’ Deferred Compensation Plan
Shares issued to CEO in lieu of cash compensation
Vesting of nonvested shares
Treasury stock received for vested share tax payments
|
2009-12-31 |
| 2009-03-16 | 6678.56 | 未披露 | 定期报告 | 2009-03-01 |
| 2009-03-16 | 6635.47 | 3.69 |
更多>>
from December 31, 2007 to December 31, 2008
Conversion of series B1 convertible preferred stock
Shares issued in private placements
Shares sold at the market
Exercise of stock options
Employee share purchases
Shares issued under Directors’ Deferred Compensation Plan
Shares issued to a consultant
Vesting of nonvested shares
Treasury stock received for vested share tax payments
|
2008-12-31 |
| 2008-03-17 | 5658.76 | 未披露 | 定期报告 | 2008-03-01 |
| 2008-03-17 | 4755.11 | 4.69 |
更多>>
from December 31, 2006 to December 31, 2007
Shares issued in private placement
Employee share purchases
Shares issued under Directors’ Deferred Compensation Plan
Shares issued to a consultant
Vesting of nonvested shares
Treasury stock received for nonvested share tax payments
|
2007-12-31 |
| 2007-03-16 | 4587.96 | 未披露 | 定期报告 | 2007-03-01 |
| 2007-03-16 | 4584.38 | 3.16 |
更多>>
from December 31, 2005 to December 31, 2006
Exercise of stock options
Employee stock purchases
|
2006-12-31 |
| 2006-03-15 | 4565.61 | 未披露 | 定期报告 | 2006-02-15 |
| 2006-03-15 | 4559.12 | 3.16 |
更多>>
from December 31, 2004 to December 31, 2005
Employee stock purchases
|
2005-12-31 |
| 2005-03-31 | 4556.47 | 未披露 | 定期报告 | 2005-03-24 |
| 2005-03-31 | 4553.60 | 3.16 |
更多>>
from December 31, 2003 to December 31, 2004
Exercise of stock options
Issuance of common stock in follow-on offering in February 2004, $10.50 per share (net of issuance costs of $3,179,516)
Employee stock purchases
Issuance of stock in asset acquisition
|
2004-12-31 |
| 2004-03-15 | 4506.19 | 未披露 | 定期报告 | 2004-03-08 |
| 2004-03-15 | 3952.27 | 3.16 |
更多>>
from December 31, 2002 to December 31, 2003
Issuance of Series A convertible preferred stock, net of expenses of $13,556
Exercise of stock options
Issuance of common stock in follow-on offering on January 28, 2003, $9.92.00 per share (net of issuance costs of $2,458,000)
Employee stock purchases
|
2003-12-31 |
| 2003-03-27 | 3938.31 | 未披露 | 定期报告 | 2003-03-19 |
| 2003-03-27 | 3311.31 | 未披露 |
更多>>
from December 31, 2001 to December 31, 2002
Exercise of stock options
Issuance of common stock in follow-on offering on January 16, 2002, $15.00 per share (net of issuance costs of $3,989,000)
Employee stock purchases
|
2002-12-31 |
| 2002-03-28 | 3306.60 | 未披露 | 定期报告 | 2002-03-19 |
| 2002-03-28 | 2901.46 | 未披露 |
更多>>
from December 31, 2000 to December 31, 2001
Exercise of stock options and warrants
Issuance of common stock in merger on July 12, 2001, $18.505 per share
Employee stock purchase program
|
2001-12-31 |
| 2001-03-28 | 2744.84 | 未披露 | 定期报告 | 2001-03-19 |
| 2001-03-28 | 2731.63 | 未披露 |
更多>>
from December 31, 1999 to December 31, 2000
Exercise of stock options and warrants
Issuance of common stock in initial public offering on February 9, 2000, $18 per share (net of issuance costs of $6,220,830)
Issuance of common stock in merger on November 16, 2000, $15.98 per share
Shares issued under employee stock purchase program
|
2000-12-31 |
one-for-twenty reverse stock split of its issued and outstanding common stock
From December 31,2022 to December 31,2023
Shares sold at the market
Payment of CEO payroll in shares
Issuance of director deferred shares
Issuance of shares for services
Vesting of nonvested shares
Exercise of stock options and employee share purchases
Issuance of shares for employee bonus
Retirement of treasury shares
From June 30, 2023 to September 30, 2023
Vesting of nonvested shares
Employee share purchases
Shares sold at the market
Issuance of shares for services
Payment of CEO payroll in shares
From March 31, 2023 to June 30, 2023
Retirement of treasury shares
Issuance of shares for employee bonus
Shares sold at the market
Vesting of nonvested shares
From December 31, 2022 to March 31, 2023
Shares sold at the market
Issuance of director deferred shares
Issuance of shares for services
Vesting of nonvested shares
Exercise of stock options and employee share purchases
Issuance of shares for employee bonus
Retirement of treasury shares
From December 31, 2021 to December 31, 2022
Vesting of nonvested shares
Shares sold at the market
Issuance of shares for services
Issuance of director deferred shares
Exercise of stock options and employee share purchases
Issuance of shares for milestone achievement
Issuance of shares for employee bonuses
Retirement of treasury shares
From June 30, 2022 to September 30, 2022
Exercise of stock options and employee share purchases
Issuance of shares for services
Vesting of nonvested shares
Shares sold at the market
From March 31, 2022 to June 30, 2022
Shares sold at the market
Issuance of shares for milestone achievement
Issuance of shares for services
Exercise of stock options
Issuance of shares for employee bonus
Retirement of treasury shares
From December 31, 2021 to March 31, 2022
Shares sold at the market
Issuance of director deferred shares
Issuance of shares for services
Vesting of nonvested shares
Exercise of stock options and employee share purchases
Issuance of shares for employee bonus
Retirement of treasury shares
From December 31, 2020 to December 31, 2021
Conversion of series C-1 convertible preferred stock
Vesting of nonvested shares
Shares sold at the market
Payment of CEO payroll in shares
Issuance of shares for services
Exercise of stock options and employee share purchases
Issuance of shares for employee bonuses
Retirement of treasury shares
From June 30, 2021 to September 30, 2021
Conversion of series C-1 convertible preferred stock
Shares sold at the market
Payment of CEO payroll in shares
Issuance of shares for services
Exercise of stock options and employee share purchases
Vesting of nonvested shares
Issuance of shares for employee bonus
Retirement of treasury shares
From March 31, 2021 to June 30, 2021
Shares sold at the market
Payment of CEO payroll in shares
Issuance of shares for services
Conversion of series C-1 convertible preferred stock
Exercise of stock options
Issuance of shares for 2020 employee bonus
Retirement of treasury shares
From December 31, 2020 To March 31, 2021
Shares sold at the market
Payment of CEO payroll in shares
Issuance of shares for services
Conversion of series C-1 convertible preferred stock
Exercise of stock options and employee share purchases
from December 31, 2019 to December 31, 2020
Vesting of nonvested shares
Shares sold at the market
Shares sold under stock purchase agreement
Issuance of shares for business acquisition
Payment of CEO payroll in shares
Payment of consultants in shares
Exercise of stock options and employee share purchases
From June 30, 2020 to September 30, 2020
Shares sold at the market
Shares sold under stock purchase agreement
Payment of CEO payroll in shares
Payment of consultant in shares
Exercise of stock options and employee share purchases
Vesting of nonvested shares
From March 31, 2020 to June 30, 2020
Shares sold at the market
Issuance of shares for business acquisition
Payment of CEO payroll in shares
Payment of consultant in shares
Exercise of stock options
Vesting of nonvested shares
From December 31, 2019 to March 31, 2020
Shares sold at the market
Payment of consultant in shares
Exercise of stock options and employee share purchases
From December 31, 2018 to December 31, 2019
Conversion of Series C-1 convertible preferred stock
Vesting of nonvested shares
Shares sold under stock purchase agreement
Payment of consultant in shares
Exercise of stock options and employee share purchases
from June 30, 2019 to September 30, 2019
Payment of consultant in shares
Exercise of stock options and employee share purchases
Vesting of nonvested shares
From March 31, 2019 to June 30, 2019
Conversion of Series C-1 convertible preferred stock
Vesting of nonvested shares
from December 31, 2018 to March 31, 2019
Shares sold under stock purchase agreement
Conversion of Series C-1 convertible preferred stock
Payment of consultant in shares
Exercise of stock options and employee share purchases
from December 31, 2017 to December 31, 2018
Vesting of nonvested shares
Shares sold at the market
Issuance of Series C-1 convertible preferred stock, net of issuance costs of $122,000
Payment of consultant in shares
Exercise of stock options and employee share purchases
from December 31, 2016 to December 31, 2017
Shares sold under Stock Purchase Agreement
Vesting of nonvested shares
Shares sold at the market
Retirement of treasury shares
Issuance of shares for milestones
Issuance of stock for acquisition of SECANT yeast display technology
Exercise of stock options and employee share purchases
from December 31, 2015 to December 31, 2016
Vesting of nonvested shares
Shares sold at the market
Issuance of director shares for compensation
Retirement of treasury shares
Issuance of shares for milestones
Exercise of stock options
Employee share purchases
From December 31, 2014 to December 31, 2015
Shares sold in underwritten public offering
Vesting of nonvested shares
Issuance of stock for acquisition of SECANT yeast display technology
Shares sold under Stock Purchase Agreement
Issuance of shares related to milestone achievement
Issuance of stock in connection with XOMA antibody manufacturing facility acquisition
Issuance of stock in connection with PhosImmune acquisition
Issuance of stock for settlement of contingent royalty obligation
Exercise of stock options
Employee share purchases
from December 31, 2013 to December 31, 2014
Shares sold at the market
Shares sold in registered direct offering
Vesting of nonvested shares
Issuance of stock for acquisition
Shares issued to CEO in lieu of cash compensation
Shares issued for acquisition liability
Retirement of treasury shares
Retirement of preferred shares
Shares issued to settle convertible notes
Exercise of stock options
Employee share purchases
from December 31, 2012 to December 31, 2013
Common stock issued to preferred shareholder
Shares sold at the market
Extinguishment of debt
Shares sold in registered direct offering
Vesting of nonvested shares
Shares issued to CEO in lieu of cash compensation
Exercise of stock options
Employee share purchases
from December 31, 2011 to December 31, 2012
Shares sold at the market
Vesting of nonvested shares
Shares issued to CEO in lieu of cash compensation
Shares issued to consultants for services
Exercise of stock options
Employee share purchases
Shares issued to director for services
Issuance of director deferred shares
from December 31, 2010 to December 31, 2011
Shares sold at the market
Shares issued in private placements
Vesting of nonvested shares
Shares issued to CEO in lieu of cash compensation
Shares issued to consultants for services
Exercise of stock options
Employee share purchases
Shares issued to director for services
Shares issued in private placements
Shares sold at the market
Shares issued to repurchase convertible senior notes
Exercise of stock options
Employee share purchases
Shares issued to consultants for services
Shares issued to CEO in lieu of cash compensation
Vesting of nonvested shares
from December 31, 2008 to December 31, 2009
Conversion of series B2 preferred shares
Shares issued in private placements
Shares issued to repurchase convertible senior notes
Exercise of stock options
Employee share purchases
Shares issued under Directors’ Deferred Compensation Plan
Shares issued to CEO in lieu of cash compensation
Vesting of nonvested shares
Treasury stock received for vested share tax payments
from December 31, 2007 to December 31, 2008
Conversion of series B1 convertible preferred stock
Shares issued in private placements
Shares sold at the market
Exercise of stock options
Employee share purchases
Shares issued under Directors’ Deferred Compensation Plan
Shares issued to a consultant
Vesting of nonvested shares
Treasury stock received for vested share tax payments
from December 31, 2006 to December 31, 2007
Shares issued in private placement
Employee share purchases
Shares issued under Directors’ Deferred Compensation Plan
Shares issued to a consultant
Vesting of nonvested shares
Treasury stock received for nonvested share tax payments
from December 31, 2005 to December 31, 2006
Exercise of stock options
Employee stock purchases
from December 31, 2004 to December 31, 2005
Employee stock purchases
from December 31, 2003 to December 31, 2004
Exercise of stock options
Issuance of common stock in follow-on offering in February 2004, $10.50 per share (net of issuance costs of $3,179,516)
Employee stock purchases
Issuance of stock in asset acquisition
from December 31, 2002 to December 31, 2003
Issuance of Series A convertible preferred stock, net of expenses of $13,556
Exercise of stock options
Issuance of common stock in follow-on offering on January 28, 2003, $9.92.00 per share (net of issuance costs of $2,458,000)
Employee stock purchases
from December 31, 2001 to December 31, 2002
Exercise of stock options
Issuance of common stock in follow-on offering on January 16, 2002, $15.00 per share (net of issuance costs of $3,989,000)
Employee stock purchases
from December 31, 2000 to December 31, 2001
Exercise of stock options and warrants
Issuance of common stock in merger on July 12, 2001, $18.505 per share
Employee stock purchase program
from December 31, 1999 to December 31, 2000
Exercise of stock options and warrants
Issuance of common stock in initial public offering on February 9, 2000, $18 per share (net of issuance costs of $6,220,830)
Issuance of common stock in merger on November 16, 2000, $15.98 per share
Shares issued under employee stock purchase program