ANTH

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From December 31, 2017 to March 31, 2018 Issuance of common stock pursuant to employee stock purchase plan Issuance of common stock pursuant to exercise of warrants Issuance of common stock pursuant to an equity purchase agreement,net of issuance cost of $16 Issuance of common stock for cash at $1.25 per share in a private placement,net of issuance cost of $450 Issuance of Class Y convertible preferred stock for cash at $1.25 per share in a private placement Conversion of Class Y convertible preferred stock into common stock Conversion of Series X convertible preferred stock into common stock

from December 31, 2016 to December 31, 2017 Issuance of common stock pursuant to exercise of employee stock purchase plan Issuance of common stock pursuant to exercise of warrants Issuance of common stock pursuant to an equity purchase agreement, net of issuance cost of $316 Issuance of common stock and warrants for cash at $4.00 per share, net of warrant liability of $14,700 Issuance of common stock and warrants for cash at $1.25 per share, net of issuance cost of $694 Conversion of Series X convertible preferred stock into common stock Reclassification of Series X convertible preferred stock from temporary to permanent equity

From December 31,2016 To September 30, 2017 Reclassification of contingently redeemable Series X convertible preferred stock Conversion of Series X convertible preferred stock into common stock Issuance of common stock and warrants for cash at $4.00 per share, net of warrant liability of $14,700 Issuance of common stock pursuant to an equity purchase agreement, net of issuance cost of $316

From December 31, 2016 to June 30, 2017 Issuance of common stock pursuant to exercise of stock options and employee stock purchase plan Issuance of common stock and warrants for cash at $4.00 per share, net of warrant liability of $14,700 Issuance of common stock pursuant to an equity purchase agreement, net of issuance cost of $255 Reclassification of contingently redeemable Series X convertible preferred stock Conversion of Series X convertible preferred stock into common stock

from December 31, 2016 to May 1, 2017 Conversion of Series X convertible preferred stock into common stock Issuance of common stock pursuant to exercise of stock options and employee stock purchase plan Issuance of common stock and warrants for cash at $4.00 per share, net of warrant liability of $14,700 Anthera Pharmaceuticals, Inc. effected a 1-for-8 reverse stock split of the Company’s common stock (the “Reverse Stock Split”).The Certificate of Amendment will become effective at 5:00 p.m Eastern Time on April 28, 2017.

from December 31, 2015 to December 31, 2016 Issuance of common stock pursuant to exercise of stock options and employee stock purchase plan Issuance of common stock pursuant to an at-the-market equity program, net of issuance costs of $277 Issuance of common stock pursuant to an equity purchase agreement, net of issuance costs of $87 Conversion of Series X convertible preferred stock into common stock

From December 31, 2015 to September 30, 2016 Issuance of Series X contingently redeemable, convertible preferred stock, net of issuance costs of $80 Issuance of common stock pursuant to exercise of stock options and employee stock purchase plan Issuance of common stock pursuant to an at-the-market equity program, net of issuance cost of $265 Issuance of common stock pursuant to an equity purchase agreement, net of issuance cost of $87

From December 31, 2014 to December 31, 2015 Issuance of common stock upon release of restricted stock units Issuance of common stock pursuant to exercise of stock options and employee stock purchase plan Issuance of common stock pursuant to an equity purchase agreement, net of issuance cost of $60 Issuance of common stock pursuant to an at-the-market equity program, net of issuance cost of $379 Issuance of common stock for cash at average $5.62 per share, net of issuance cost of $3,744 Issuance of common stock to Zenyaku Kogyo Co., Ltd. for cash Issuance of common stock to Amgen to settle a license fee obligation

from December 31, 2013 to December 31, 2014 Issuance of common stock upon release of restricted stock units Issuance of common stock pursuant to exercise of stock options and employee stock purchase plan Issuance of common stock pursuant to an equity purchase agreement, net of issuance cost of $7 Issuance of common stock pursuant to an at-the-market equity program, net of issuance cost of $354

from December 31, 2012 to December 31, 2013 Issuance of common stock upon release of restricted stock units Issuance of common stock pursuant to employee stock purchase plan Issuance of common stock for cash at $5.28 per share, net of issuance cost of $474 Issuance of common stock pursuant to an equity purchase agreement , net of issuance cost of $471 On July 12, 2013, the Company announced a 1-for-8 reverse split of its outstanding common stock resulting in a reduction of its total common stock issued and outstanding from approximately 152,921,768 shares to 19,115,189 shares. The reverse stock split affected all stockholders of the Company’s common stock equally; the reverse split was effective July 15, 2013.

On July 12, 2013, the Company announced a 1-for-8 reverse split of its outstanding common stock resulting in a reduction of its total common stock issued and outstanding from approximately 152,921,768 shares to 19,115,189 shares. The reverse stock split affected all stockholders of the Company’s common stock equally; the reverse split was effective July 15, 2013.

from December 31, 2011 to December 31, 2012 Issuance of common stock upon exercise of stock options Issuance of common stock for cash at $1.00 per share—net of issuance cost of $98,035 Issuance of common stock upon release of restricted stock units Issuance of common stock pursuant to employee stock purchase plan Net change of early exercise of stock options and liability

from December 31, 2010 to December 31, 2011 Issuance of common stock upon exercise of stock options Issuance of common stock for cash at $7.50 per share—net of issuance cost of $198 Issuance of common stock upon exercise of warrants Issuance of common stock upon release of restricted stock units Issuance of common stock pursuant to employee stock purchase plan Net change of early exercise of stock options and liability

from December 31, 2009 to December 31, 2010 Conversion of convertible preferred stock to common stock at a ratio of 1:1 Issuance of common stock for cash at $7.00 per share — net of issuance cost of $3,039,257 Issuance of common stock upon conversion of convertible promissory notes and accrued interest at $5.25 and $6.28 per share Issuance of common stock upon release of escrow funds Issuance of common stock upon cashless exercise of warrants Issuance of common stock to collaborator in lieu of milestone payment Issuance of common stock upon exercise of overallotment by underwriters net of issuance cost of $17,291 Issuance of common stock upon exercise of stock options Issuance of common stock pursuant to employee stock purchase plan Issuance of common stock upon private placement transaction, net of issuance cost of $508,384 Net change of early exercise of stock options and liability

from December 31, 2009 to September 30, 2010 Conversion of convertible preferred stock to common stock at a ratio of 1:1 Issuance of common stock for cash at $7.00 per share—net of issuance cost of $3,021,966 Issuance of common stock upon conversion of convertible promissory notes and accrued interest at $5.25 and $6.28 per share Issuance of common stock upon release of escrow funds Issuance of common stock upon cashless exercise of warrants Issuance of common stock to collaborator in lieu of milestone payment Issuance of common stock upon exercise of overallotment by underwriters net of issuance cost of $17,291 Issuance of common stock upon exercise of stock options Issuance of common stock upon private placement transaction, net of issuance cost of $468,964 Net change of early exercise of stock options and liability

from December 31, 2009 to June 30, 2010 Conversion of convertible preferred stock to common stock at a ratio of 1:1 Issuance of common stock for cash at $7.00 per share—net of issuance cost of $3,021,966 Issuance of common stock upon conversion of convertible promissory notes and accrued interest at $5.25 and $6.28 per share Issuance of common stock upon release of escrow funds Issuance of common stock upon cashless exercise of warrants Issuance of common stock to collaborator in lieu of milestone payment Issuance of common stock upon exercise of overallotment by underwriters net of issuance cost of $17,291 Issuance of common stock upon exercise of stock options Net change of early exercise of stock options and liability