股本结构
单位：万股
| 公告日期 | 2024-04-26 | 2024-04-26 | 2024-03-05 | 2024-03-05 | 2023-11-02 | 2023-11-02 |
|---|---|---|---|---|---|---|
| 证券总股本 | 18489.01 | 18488.69 | 18128.27 | 18124.80 | 18119.70 | 18116.56 |
| 普通股本 | 18489.01 | 18488.69 | 18128.27 | 18124.80 | 18119.70 | 18116.56 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2024-04-12 | 2024-04-01 | 2024-02-08 | 2023-12-31 | 2023-10-19 | 2023-09-30 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2024-04-26 | 18489.01 | 未披露 | 定期报告 | 2024-04-12 |
| 2024-04-26 | 18488.69 | 未披露 | 定期报告 | 2024-04-01 |
| 2024-03-05 | 18128.27 | 未披露 | 定期报告 | 2024-02-08 |
| 2024-03-05 | 18124.80 | 未披露 |
更多>>
From December 31,2022 to December 31,2023
Issuance of common stock from exercise of stock options,vesting of restricted stock units, and ESPP purchases
|
2023-12-31 |
| 2023-11-02 | 18119.70 | 未披露 | 定期报告 | 2023-10-19 |
| 2023-11-02 | 18116.56 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
|
2023-09-30 |
| 2023-08-03 | 18080.41 | 未披露 | 定期报告 | 2023-07-21 |
| 2023-05-04 | 18055.22 | 未披露 | 定期报告 | 2023-04-21 |
| 2023-04-28 | 18084.41 | 未披露 | 定期报告 | 2023-04-10 |
| 2023-05-04 | 18047.20 | 未披露 |
更多>>
From December 31, 2022 to March 31, 2023
Issuance of common stock from exercise of stock options,vesting of restricted stock units, and ESPP purchases
|
2023-03-31 |
| 2023-03-01 | 17761.79 | 未披露 | 定期报告 | 2023-02-08 |
| 2023-03-01 | 17758.20 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
|
2022-12-31 |
| 2022-11-03 | 17742.09 | 未披露 | 定期报告 | 2022-10-20 |
| 2022-11-03 | 17740.30 | 未披露 |
更多>>
From June 30, 2022 to September 30, 2022
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
|
2022-09-30 |
| 2022-08-04 | 17709.04 | 未披露 | 定期报告 | 2022-07-22 |
| 2022-08-04 | 17707.80 | 未披露 |
更多>>
From March 31, 2022 to June 30, 2022
Issuance of common stock from exercise of stock options and vesting of restricted stock units
|
2022-06-30 |
| 2022-05-05 | 17689.82 | 未披露 | 定期报告 | 2022-04-22 |
| 2022-05-05 | 17680.40 | 未披露 |
更多>>
From December 31, 2021 to March 31, 2022
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
|
2022-03-31 |
| 2022-02-22 | 17372.15 | 未披露 | 定期报告 | 2022-02-08 |
| 2022-02-22 | 17367.00 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Issuance of common stock from public offering, net of offering costs
Issuance of common stock from exercise of stock options,vesting of restricted stock units, and ESPP purchases
|
2021-12-31 |
| 2021-11-02 | 17226.64 | 未披露 | 定期报告 | 2021-10-21 |
| 2021-11-02 | 17225.60 | 未披露 |
更多>>
From June 30, 2021 to September 30, 2021
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
|
2021-09-30 |
| 2021-08-03 | 17162.68 | 未披露 | 定期报告 | 2021-07-22 |
| 2021-08-03 | 17157.20 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Issuance of common stock from exercise of stock options and vesting of restricted stock units
|
2021-06-30 |
| 2021-05-04 | 17117.15 | 未披露 | 定期报告 | 2021-04-21 |
| 2021-04-23 | 17083.01 | 未披露 | 定期报告 | 2021-04-02 |
| 2021-05-04 | 17079.10 | 未披露 |
更多>>
from December 31, 2020 to March 31, 2021
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
|
2021-03-31 |
| 2021-02-25 | 16822.01 | 未披露 | 定期报告 | 2021-02-10 |
| 2021-02-25 | 16817.00 | 未披露 |
更多>>
From December 31, 2019 to December 31, 2020
Issuance of common stock from public offerings, net of offering costs
Issuance of common stock from exercise of stock options,vesting of restricted stock units, and ESPP purchases
|
2020-12-31 |
| 2020-10-29 | 16714.20 | 未披露 | 定期报告 | 2020-10-20 |
| 2020-12-11 | 16707.36 | 未披露 |
更多>>
From June 30, 2020 to September 30, 2020
Issuance of common stock from exercise of stock options,vesting of restricted stock units,and ESPP purchases
|
2020-09-30 |
| 2020-08-05 | 16617.13 | 未披露 | 定期报告 | 2020-07-21 |
| 2020-08-05 | 16601.20 | 未披露 |
更多>>
From March 31, 2020 to June 30, 2020
Issuance of common stock from public offerings, net of offering costs
Issuance of common stock from exercise of stock options and vesting of restricted stock units
|
2020-06-30 |
| 2020-05-05 | 16398.78 | 未披露 | 定期报告 | 2020-04-21 |
| 2020-04-24 | 16406.59 | 未披露 | 定期报告 | 2020-04-02 |
| 2020-05-05 | 16396.10 | 未披露 |
更多>>
From December 31, 2019 to March 31, 2020
Issuance of common stock from public offerings, net of offering costs
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
|
2020-03-31 |
| 2020-04-24 | 16395.50 | 未披露 | 定期报告 | 2020-03-27 |
| 2020-02-21 | 16216.57 | 未披露 | 定期报告 | 2020-02-10 |
| 2020-02-21 | 14429.10 | 未披露 |
更多>>
From December 31, 2018 to December 31, 2019
Issuance of common stock from public offering, net of offering costs
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
|
2019-12-31 |
| 2019-10-30 | 14208.88 | 未披露 | 定期报告 | 2019-10-21 |
| 2019-10-30 | 14201.00 | 未披露 |
更多>>
from June 30, 2019 to September 30, 2019
Issuance of common stock from public offering, net of offering costs
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
|
2019-09-30 |
| 2019-08-01 | 14032.15 | 未披露 | 定期报告 | 2019-07-22 |
| 2019-08-01 | 14006.10 | 未披露 |
更多>>
From March 31, 2019 To June 30, 2019
Issuance of common stock from public offering, net of offering costs
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
|
2019-06-30 |
| 2019-05-07 | 13783.59 | 未披露 | 定期报告 | 2019-04-25 |
| 2019-04-26 | 13783.58 | 未披露 | 定期报告 | 2019-04-12 |
| 2019-05-07 | 13781.80 | 未披露 |
更多>>
from December 31, 2018 to March 31, 2019
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
|
2019-03-31 |
| 2019-02-27 | 13695.31 | 未披露 | 定期报告 | 2019-02-15 |
| 2019-02-27 | 13685.30 | 未披露 |
更多>>
from December 31, 2017 to December 31, 2018
Issuance of common stock from public offering, net of offering costs
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and purchases from ESPP
|
2018-12-31 |
| 2018-11-01 | 13568.92 | 未披露 | 定期报告 | 2018-10-22 |
| 2018-08-02 | 13381.39 | 未披露 | 定期报告 | 2018-07-24 |
| 2018-05-08 | 13054.45 | 未披露 | 定期报告 | 2018-04-27 |
| 2018-04-27 | 13060.26 | 未披露 | 定期报告 | 2018-04-13 |
| 2018-03-08 | 12959.73 | 未披露 | 定期报告 | 2018-02-22 |
| 2018-03-08 | 11555.50 | 未披露 |
更多>>
from December 31, 2016 to December 31, 2017
Issuance of common stock from public offering, net of offering costs
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and purchases from ESPP
|
2017-12-31 |
| 2017-12-29 | 11555.46 | 未披露 | 定期报告 | 2017-12-27 |
| 2017-11-03 | 11408.64 | 未披露 | 定期报告 | 2017-10-26 |
| 2017-08-04 | 10913.79 | 未披露 | 定期报告 | 2017-07-27 |
| 2017-05-31 | 10485.85 | 未披露 | 定期报告 | 2017-05-30 |
| 2017-05-04 | 10393.84 | 未披露 | 定期报告 | 2017-04-27 |
| 2017-04-28 | 10379.16 | 未披露 | 定期报告 | 2017-04-13 |
| 2017-03-08 | 10347.47 | 未披露 | 定期报告 | 2017-02-24 |
| 2017-03-08 | 10347.50 | 未披露 |
更多>>
from December 31, 2015 to December 31, 2016
Issuance of common stock from public offering, net of offering costs
Issuance of common stock from exercise of stock options and purchases from ESPP
|
2016-12-31 |
| 2016-11-04 | 10346.68 | 未披露 | 定期报告 | 2016-10-27 |
| 2016-08-05 | 10270.93 | 未披露 | 定期报告 | 2016-07-28 |
| 2016-05-06 | 10171.08 | 未披露 | 定期报告 | 2016-04-28 |
| 2016-04-29 | 10133.49 | 未披露 | 定期报告 | 2016-04-15 |
| 2016-03-09 | 9936.07 | 未披露 | 定期报告 | 2016-02-26 |
| 2016-03-09 | 9909.50 | 未披露 |
更多>>
from December 31, 2014 to December 31, 2015
Issuance of common stock from public offering, net of offering costs
Issuance of common stock from exercise of stock options and warrants, and purchases from ESPP
|
2015-12-31 |
| 2015-11-06 | 9713.80 | 未披露 | 定期报告 | 2015-10-23 |
| 2015-08-07 | 9677.63 | 未披露 | 定期报告 | 2015-07-24 |
| 2015-05-08 | 9537.10 | 未披露 | 定期报告 | 2015-04-30 |
| 2015-04-30 | 9541.56 | 未披露 | 定期报告 | 2015-04-15 |
| 2015-03-16 | 9517.77 | 未披露 | 定期报告 | 2015-02-27 |
| 2015-03-16 | 8040.40 | 未披露 |
更多>>
from December 31, 2013 to December 31, 2014
Issuance of common stock from public offering, net of expenses of $470
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP
|
2014-12-31 |
| 2014-11-07 | 7826.94 | 未披露 | 定期报告 | 2014-10-24 |
| 2014-08-08 | 7404.80 | 未披露 | 定期报告 | 2014-07-25 |
| 2014-08-08 | 7389.42 | 未披露 | 定期报告 | 2014-06-30 |
| 2014-05-12 | 7251.30 | 未披露 | 定期报告 | 2014-04-24 |
| 2014-04-30 | 7243.82 | 未披露 | 定期报告 | 2014-04-14 |
| 2014-03-07 | 7214.90 | 未披露 | 定期报告 | 2014-02-26 |
| 2014-03-07 | 7185.90 | 未披露 |
更多>>
from December 31, 2012 to December 31, 2013
Issuance of common stock from public offering, net of expenses of $2,733
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP
|
2013-12-31 |
| 2013-11-01 | 7045.60 | 未披露 | 定期报告 | 2013-10-28 |
| 2013-08-02 | 6973.60 | 未披露 | 定期报告 | 2013-07-24 |
| 2013-05-03 | 6971.60 | 未披露 | 定期报告 | 2013-04-24 |
| 2013-04-29 | 6971.53 | 未披露 | 定期报告 | 2013-04-15 |
| 2013-03-12 | 6010.30 | 未披露 | 定期报告 | 2013-03-01 |
| 2013-03-12 | 5625.20 | 未披露 |
更多>>
from December 31, 2011 to December 31, 2012
Preferred stock conversion
Issuance of common stock from public offering, net of expenses of $550
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP
Preferred stock conversion
|
2012-12-31 |
| 2012-11-08 | 5547.70 | 未披露 | 定期报告 | 2012-10-30 |
| 2012-08-08 | 5482.20 | 未披露 | 定期报告 | 2012-07-23 |
| 2012-05-07 | 5441.10 | 未披露 | 定期报告 | 2012-04-23 |
| 2012-03-05 | 5421.30 | 未披露 | 定期报告 | 2012-02-22 |
| 2012-03-05 | 5121.10 | 0.30 |
更多>>
from December 31, 2010 to December 31, 2011
Issuance of common stock from public offering, net of expenses of $420
Issuance of common stock from exercise of stock options and purchases from ESPP
|
2011-12-31 |
| 2011-11-03 | 4810.00 | 未披露 | 定期报告 | 2011-10-26 |
| 2011-08-08 | 4770.00 | 未披露 | 定期报告 | 2011-07-29 |
| 2011-03-16 | 4760.00 | 未披露 | 定期报告 | 2011-02-28 |
| 2011-03-16 | 4732.90 | 0.30 |
更多>>
Issuance of common stock from acquisition and public offering
Issuance of common stock from exercise of stock options and purchases from ESPP
|
2010-12-31 |
| 2010-11-15 | 4000.00 | 未披露 | 定期报告 | 2010-10-05 |
| 2010-05-12 | 3890.00 | 未披露 | 定期报告 | 2010-04-28 |
| 2010-03-11 | 3880.00 | 未披露 | 定期报告 | 2010-02-19 |
| 2010-03-11 | 3867.80 | 0.30 |
更多>>
from December 31, 2008 to December 31, 2009
Issuance of common stock, net of expenses of $3,865
Issuance of common stock under stock option restricted stock and employee stock purchase plans
|
2009-12-31 |
| 2009-03-13 | 3260.00 | 未披露 | 定期报告 | 2009-02-19 |
| 2009-03-13 | 3254.40 | 0.30 |
更多>>
from December 31, 2007 to December 31, 2008
Issuance of common stock under stock option and employee stock purchase plans
|
2008-12-31 |
| 2008-02-27 | 3220.00 | 未披露 | 定期报告 | 2008-02-08 |
| 2008-02-27 | 3211.20 | 0.30 |
更多>>
from December 31, 2006 to December 31, 2007
Issuance of common stock under stock option and employee stock purchase plans
|
2007-12-31 |
| 2007-02-26 | 3170.00 | 未披露 | 定期报告 | 2007-02-08 |
| 2007-02-26 | 3173.50 | 0.30 |
更多>>
from December 31, 2005 to December 31, 2006
Issuance of common stock, net of expenses of $2,323
Issuance of common stock under stock option restricted stock, and employee stock purchase plans
|
2006-12-31 |
| 2006-02-27 | 2250.96 | 未披露 | 定期报告 | 2006-02-17 |
| 2006-02-27 | 2245.80 | 0.30 |
更多>>
from December 31, 2004 to December 31, 2005
Issuance of common stock under stock option restricted stock, and employee stock purchase plans
|
2005-12-31 |
| 2005-03-16 | 2229.97 | 未披露 | 定期报告 | 2005-02-28 |
| 2005-03-16 | 2221.07 | 0.33 |
更多>>
from December 31, 2003 to December 31, 2004
Issuance of common stock under stock option and employee stock purchase plans
|
2004-12-31 |
| 2004-03-15 | 2210.48 | 未披露 | 定期报告 | 2004-02-29 |
| 2004-03-15 | 2206.02 | 0.33 |
更多>>
from December 31, 2002 to December 31, 2003
Issuance of common stock, net of expenses of $236
Issuance of common stock under stock option and employee stock purchase plans
|
2003-12-31 |
| 2003-03-28 | 1597.85 | 未披露 | 定期报告 | 2003-02-28 |
| 2003-03-28 | 1594.97 | 0.33 |
更多>>
from December 31, 2001 to December 31, 2002
Conversion of Series B preferred stock to common stock
Issuance of common stock for services
Issuance of common stock under stock option and employee stock purchase plans
|
2002-12-31 |
| 2002-04-01 | 1575.45 | 未披露 | 定期报告 | 2002-02-28 |
| 2002-04-01 | 1573.72 | 0.83 |
更多>>
from December 31, 2000 to December 31, 2001
Issuance of common stock, net of expenses of $2,812
Issuance of common stock for services
Issuance of common stock under stock option and employee stock purchase plans
|
2001-12-31 |
| 2001-03-26 | 1411.55 | 未披露 | 定期报告 | 2001-03-15 |
| 2001-03-26 | 1405.18 | 0.83 |
更多>>
from December 31, 1999 to December 31, 2000
Issuance of common stock, net of expenses of $1,314,413
Issuance of common stock under stock option and employee stock purchase plans
Common shares reacquired
|
2000-12-31 |
| 2000-03-30 | 1278.66 | 未披露 | 定期报告 | 2000-03-24 |
| 2000-03-30 | 1174.41 | 0.83 |
更多>>
from December 31, 1998 to December 31, 1999
Issuance of Series B preferred stock
Issuance of common stock
Public offering of common stock, net of expenses of $3,523,556
Issuance of common stock under stock option and employee stock purchase plans and warrant exercises
Common shares reacquired
|
1999-12-31 |
| 1999-03-29 | 943.79 | 未披露 | 定期报告 | 1999-03-23 |
| 1999-03-29 | 941.68 | 0.50 |
更多>>
from December 31, 1997 to December 31, 1998
Issuance of common stock
Issuance of common stock under stock option and employee stock purchase plans and warrant exercises
Common shares reacquired
|
1998-12-31 |
| 1998-03-06 | 922.85 | 未披露 | 定期报告 | 1998-02-28 |
| 1998-03-06 | 918.36 | 未披露 |
更多>>
from December 31, 1996 to December 31, 1997
Conversion of preferred stock
Public offering of common stock, net of expenses of $2,945,259
Issuance of common stock
Issuance of common stock under stock option and employee stock purchase plans and warrant exercises
Common shares reacquired
|
1997-12-31 |
From December 31,2022 to December 31,2023
Issuance of common stock from exercise of stock options,vesting of restricted stock units, and ESPP purchases
From June 30, 2023 to September 30, 2023
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
From December 31, 2022 to March 31, 2023
Issuance of common stock from exercise of stock options,vesting of restricted stock units, and ESPP purchases
From December 31, 2021 to December 31, 2022
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
From June 30, 2022 to September 30, 2022
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
From March 31, 2022 to June 30, 2022
Issuance of common stock from exercise of stock options and vesting of restricted stock units
From December 31, 2021 to March 31, 2022
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
From December 31, 2020 to December 31, 2021
Issuance of common stock from public offering, net of offering costs
Issuance of common stock from exercise of stock options,vesting of restricted stock units, and ESPP purchases
From June 30, 2021 to September 30, 2021
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
From March 31, 2021 to June 30, 2021
Issuance of common stock from exercise of stock options and vesting of restricted stock units
from December 31, 2020 to March 31, 2021
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
From December 31, 2019 to December 31, 2020
Issuance of common stock from public offerings, net of offering costs
Issuance of common stock from exercise of stock options,vesting of restricted stock units, and ESPP purchases
From June 30, 2020 to September 30, 2020
Issuance of common stock from exercise of stock options,vesting of restricted stock units,and ESPP purchases
From March 31, 2020 to June 30, 2020
Issuance of common stock from public offerings, net of offering costs
Issuance of common stock from exercise of stock options and vesting of restricted stock units
From December 31, 2019 to March 31, 2020
Issuance of common stock from public offerings, net of offering costs
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
From December 31, 2018 to December 31, 2019
Issuance of common stock from public offering, net of offering costs
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
from June 30, 2019 to September 30, 2019
Issuance of common stock from public offering, net of offering costs
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
From March 31, 2019 To June 30, 2019
Issuance of common stock from public offering, net of offering costs
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
from December 31, 2018 to March 31, 2019
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and ESPP purchases
from December 31, 2017 to December 31, 2018
Issuance of common stock from public offering, net of offering costs
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and purchases from ESPP
from December 31, 2016 to December 31, 2017
Issuance of common stock from public offering, net of offering costs
Issuance of common stock from exercise of stock options, vesting of restricted stock units, and purchases from ESPP
from December 31, 2015 to December 31, 2016
Issuance of common stock from public offering, net of offering costs
Issuance of common stock from exercise of stock options and purchases from ESPP
from December 31, 2014 to December 31, 2015
Issuance of common stock from public offering, net of offering costs
Issuance of common stock from exercise of stock options and warrants, and purchases from ESPP
from December 31, 2013 to December 31, 2014
Issuance of common stock from public offering, net of expenses of $470
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP
from December 31, 2012 to December 31, 2013
Issuance of common stock from public offering, net of expenses of $2,733
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP
from December 31, 2011 to December 31, 2012
Preferred stock conversion
Issuance of common stock from public offering, net of expenses of $550
Issuance of common stock from exercise of stock options and/or warrants, and purchases from ESPP
Preferred stock conversion
from December 31, 2010 to December 31, 2011
Issuance of common stock from public offering, net of expenses of $420
Issuance of common stock from exercise of stock options and purchases from ESPP
Issuance of common stock from acquisition and public offering
Issuance of common stock from exercise of stock options and purchases from ESPP
from December 31, 2008 to December 31, 2009
Issuance of common stock, net of expenses of $3,865
Issuance of common stock under stock option restricted stock and employee stock purchase plans
from December 31, 2007 to December 31, 2008
Issuance of common stock under stock option and employee stock purchase plans
from December 31, 2006 to December 31, 2007
Issuance of common stock under stock option and employee stock purchase plans
from December 31, 2005 to December 31, 2006
Issuance of common stock, net of expenses of $2,323
Issuance of common stock under stock option restricted stock, and employee stock purchase plans
from December 31, 2004 to December 31, 2005
Issuance of common stock under stock option restricted stock, and employee stock purchase plans
from December 31, 2003 to December 31, 2004
Issuance of common stock under stock option and employee stock purchase plans
from December 31, 2002 to December 31, 2003
Issuance of common stock, net of expenses of $236
Issuance of common stock under stock option and employee stock purchase plans
from December 31, 2001 to December 31, 2002
Conversion of Series B preferred stock to common stock
Issuance of common stock for services
Issuance of common stock under stock option and employee stock purchase plans
from December 31, 2000 to December 31, 2001
Issuance of common stock, net of expenses of $2,812
Issuance of common stock for services
Issuance of common stock under stock option and employee stock purchase plans
from December 31, 1999 to December 31, 2000
Issuance of common stock, net of expenses of $1,314,413
Issuance of common stock under stock option and employee stock purchase plans
Common shares reacquired
from December 31, 1998 to December 31, 1999
Issuance of Series B preferred stock
Issuance of common stock
Public offering of common stock, net of expenses of $3,523,556
Issuance of common stock under stock option and employee stock purchase plans and warrant exercises
Common shares reacquired
from December 31, 1997 to December 31, 1998
Issuance of common stock
Issuance of common stock under stock option and employee stock purchase plans and warrant exercises
Common shares reacquired
from December 31, 1996 to December 31, 1997
Conversion of preferred stock
Public offering of common stock, net of expenses of $2,945,259
Issuance of common stock
Issuance of common stock under stock option and employee stock purchase plans and warrant exercises
Common shares reacquired