CHMA

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From December 31, 2020 to March 31, 2021 Exercise of stock options

From December 31,2019 to December 31,2020 Exercise of stock options Issuance of common stock and pre-funded warrants in follow-on offering,net Issuance of common stock from cashless warrant exercise

From June 30, 2020 to September 30, 2020 Exercise of stock options Issuance of common stock and pre-funded warrants in follow-on offering,net Issuance of common stock from cashless warrant exercise

1.Common Stock Offered by the company 12,500,000 shares 2.The number of shares of common stock that will be outstanding immediately after this offering as shown above is based on 42,265,341 shares outstanding as of March 31, 2020.

from March 31, 2020 to June 30, 2020 Exercise of stock options

from December 31, 2019 to March 31, 2020 Exercise of stock options

From December 31, 2018 to December 31, 2019 Exercise of stock options Issuance of common stock in follow-on offering, net

from June 30, 2019 to September 30, 2019 Exercise of stock options Issuance of common stock in follow-on offering, net

From March 31, 2019 to June 30, 2019 Exercise of stock options Issuance of common stock in follow-on offering, net

From January 1, 2019 to March 31, 2019 Exercise of stock options

From December 31,2017 to December 31,2018 Exercise of stock options

from December 31, 2016 to December 31, 2017 Exercise of stock options

From December 31, 2015 to September 30, 2016 Exercise of stock options Exercise of warrants into common stock

from December 31, 2015 to June 30, 2016 Exercise of stock options Exercise of warrants into common stock

from December 31, 2015 to March 31, 2016 Exercise of stock options

From December 31, 2014 to December 31, 2015 Exercise of stock options Exercise of warrants Issuance of Series E redeemable convertible preferred stock, net of issuance costs of $258 and warrants for common stock Issuance of common stock, conversion of preferred stock Issuance of common stock, Initial public offering net of issuance costs of $2,394 Accretion of redeemable convertible preferred stock On June 30, 2015, the board of directors approved a 1-for-9.132 reverse stock split In connection with the closing of the IPO on July 21, 2015, all of the Company’s outstanding redeemable convertible preferred stock automatically converted into 16,403,011 shares of common stock

from December 31, 2014 to September 30, 2015 Issuance of Series E redeemable convertible preferred stock, net of issuance costs of $257,678 and warrants for common stock Issuance of common stock, conversion of preferred stock Exercise of warrants Exercise of stock options Issuance of common stock, Initial public offering net of issuance costs of $ 2,394,359 In preparation for the IPO, the Company’s board of directors and stockholders approved a 1-for-9.132 reverse stock split (the “Reverse Split”) of the Company’s common stock effective June 30, 2015

A 1-for-9.132 reverse stock split of our common stock effected on June 30, 2015 The conversion of all 149,792,472 of our outstanding shares of our preferred stock into 16,403,011 shares of common stock, which will occur immediately prior to the closing of this offering

On June 30, 2015, the board of directors approved a 1-for-9.132 reverse stock split.

from December 31, 2014 to June 30, 2015 Issuance of Series E redeemable convertible preferred stock, net of issuance costs of $257,680 and warrants for common stock Exercise of warrants Exercise of stock options In stockholders approved a 1-for-9.132 reverse stock split (the “Reverse Split”) of the Company’s common stock effective June 30, 2015. In connection with the closing of the IPO on July 21, 2015, all of the Company’s outstanding redeemable convertible preferred stock automatically converted into 16,403,011 shares of common stock.

from December 31, 2014 to March 31, 2015 Issuance of Series E redeemable convertible preferred stock, net of issuance costs of $257,680 and warrants for common stock Exercise of warrants