股本结构
单位：万股
| 公告日期 | 2026-08-06 | 2026-08-06 | 2026-05-07 | 2026-04-21 | 2026-05-07 | 2026-02-26 |
|---|---|---|---|---|---|---|
| 证券总股本 | 15984.74 | 15975.55 | 15870.97 | 15867.55 | 15865.63 | 15859.15 |
| 普通股本 | 15984.74 | 15975.55 | 15870.97 | 15867.55 | 15865.63 | 15859.15 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2026-07-31 | 2026-06-30 | 2026-05-01 | 2026-04-09 | 2026-03-31 | 2026-02-20 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2026-08-06 | 15984.74 | 未披露 | 定期报告 | 2026-07-31 |
| 2026-08-06 | 15975.55 | 未披露 |
更多>>
From March 31, 2026 to June 30,2026
Issuances under equity incentive plans
Vesting of restricted stock units
|
2026-06-30 |
| 2026-05-07 | 15870.97 | 未披露 | 定期报告 | 2026-05-01 |
| 2026-04-21 | 15867.55 | 未披露 | 定期报告 | 2026-04-09 |
| 2026-05-07 | 15865.63 | 未披露 |
更多>>
From December 31, 2025 to March 31, 2026
Issuance of common stock, net of issuance cost of $45
Issuances under equity incentive plans
Vesting of restricted stock units
|
2026-03-31 |
| 2026-02-26 | 15859.15 | 未披露 | 定期报告 | 2026-02-20 |
| 2026-02-26 | 15618.22 | 未披露 |
更多>>
From December 31, 2024 to December 31, 2025
Issuance of common stock and pre-funded warrants, net of issuance costs of $728
Issuances under equity incentive plans
Vesting of restricted stock units
|
2025-12-31 |
| 2025-12-10 | 15615.84 | 未披露 |
更多>>
Common Stock offered 9,142,857 shares by the company
|
2025-12-11 |
| 2025-12-09 | 14701.55 | 未披露 | 定期报告 | 2025-12-04 |
| 2025-11-06 | 14666.18 | 未披露 | 定期报告 | 2025-10-31 |
| 2025-11-06 | 14662.57 | 未披露 |
更多>>
From June 30, 2025 to September 30, 2025
Issuances under equity incentive plans
Vesting of restricted stock units
Stock-based compensation
|
2025-09-30 |
| 2025-08-11 | 14621.23 | 未披露 | 定期报告 | 2025-08-05 |
| 2025-08-11 | 14568.54 | 未披露 |
更多>>
From March 31, 2025 to June 30, 2025
Issuances under equity incentive plans
Vesting of restricted stock units
|
2025-06-30 |
| 2025-05-06 | 14527.63 | 未披露 | 定期报告 | 2025-04-30 |
| 2025-04-17 | 14524.22 | 未披露 | 定期报告 | 2025-04-09 |
| 2025-05-06 | 14525.13 | 未披露 |
更多>>
From December 31, 2024 to March 31, 2025
Issuances under equity incentive plans
Vesting of restricted stock units
|
2025-03-31 |
| 2025-02-27 | 14521.54 | 未披露 | 定期报告 | 2025-02-21 |
| 2025-02-27 | 14422.10 | 未披露 |
更多>>
From December 31, 2023 to December 31, 2024
Issuance of common stock and pre-funded warrants, net of issuance costs of $480
Issuances under equity incentive plans
Vesting of restricted stock units
|
2024-12-31 |
| 2024-11-06 | 14392.16 | 未披露 | 定期报告 | 2024-10-30 |
| 2024-11-06 | 14384.00 | 未披露 |
更多>>
From June 30, 2024 to September 30, 2024
Issuances under equity incentive plans
Vesting of restricted stock units
|
2024-09-30 |
| 2024-08-01 | 14316.53 | 未披露 | 定期报告 | 2024-07-25 |
| 2024-08-01 | 14312.36 | 未披露 |
更多>>
From March 31, 2024 to June 30, 2024
Issuances under equity incentive plans
Vesting of restricted stock units
|
2024-06-30 |
| 2024-05-07 | 14260.90 | 未披露 | 定期报告 | 2024-04-30 |
| 2024-04-18 | 14253.95 | 未披露 | 定期报告 | 2024-04-05 |
| 2024-05-07 | 14251.29 | 未披露 |
更多>>
From December 31, 2023 to March 31, 2024
Issuance of common stock and pre-funded warrants, net of issuance costs of $480K
Issuances under equity incentive plans
Vesting of restricted stock units
|
2024-03-31 |
| 2024-03-22 | 14245.83 | 未披露 | 定期报告 | 2024-03-15 |
| 2024-02-28 | 13916.02 | 未披露 | 定期报告 | 2024-02-20 |
| 2024-02-28 | 13838.55 | 未披露 |
更多>>
From December 31, 2022 to December 31, 2023
Issuances under equity incentive plans
Vesting of restricted stock units
|
2023-12-31 |
| 2023-11-07 | 13819.68 | 未披露 | 定期报告 | 2023-10-30 |
| 2023-11-07 | 13805.18 | 未披露 |
更多>>
From June 30, 2023 to September 30, 2023
Issuances under equity incentive plans
Vesting of restricted stock units
|
2023-09-30 |
| 2023-08-08 | 13742.21 | 未披露 | 定期报告 | 2023-07-31 |
| 2023-05-08 | 13688.89 | 未披露 | 定期报告 | 2023-05-01 |
| 2023-04-18 | 13673.63 | 未披露 | 定期报告 | 2023-04-04 |
| 2023-05-08 | 13674.16 | 未披露 |
更多>>
From December 31, 2022 to March 31, 2023
Issuances under equity incentive plans
Vesting of restricted stock units
|
2023-03-31 |
| 2023-02-27 | 13667.76 | 未披露 | 定期报告 | 2023-02-21 |
| 2023-02-27 | 13596.59 | 未披露 |
更多>>
From December 31, 2021 to December 31, 2022
Issuances under equity incentive plans
Vesting of restricted stock units
Issuance of common stock in follow-on offering, net of issuance costs of $1,060
|
2022-12-31 |
| 2022-11-03 | 13581.37 | 未披露 | 定期报告 | 2022-10-27 |
| 2022-10-20 | 13417.38 | 未披露 |
更多>>
Common stock offered 10,377,359 shares by the company
|
2022-10-24 |
| 2022-11-03 | 12379.64 | 未披露 |
更多>>
From June 30, 2022 to September 30, 2022
Issuances under equity incentive plans
Vesting of restricted stock units
|
2022-09-30 |
| 2022-08-08 | 12334.82 | 未披露 | 定期报告 | 2022-08-01 |
| 2022-08-08 | 12315.73 | 未披露 |
更多>>
From March 31, 2022 to June 30, 2022
Issuances under equity incentive plans
Vesting of restricted stock units
|
2022-06-30 |
| 2022-05-05 | 12294.84 | 未披露 | 定期报告 | 2022-04-28 |
| 2022-04-19 | 12289.37 | 未披露 | 定期报告 | 2022-04-11 |
| 2022-05-05 | 12285.79 | 未披露 |
更多>>
From December 31, 2021 to March 31, 2022
Issuances under equity incentive plans
Vesting of restricted stock units
|
2022-03-31 |
| 2022-02-28 | 12283.34 | 未披露 | 定期报告 | 2022-02-18 |
| 2022-02-28 | 12228.33 | 未披露 |
更多>>
From December 31, 2020 to December 31, 2021
Issuances under equity incentive plans
Vesting of restricted stock awards
|
2021-12-31 |
| 2021-11-04 | 12212.56 | 未披露 | 定期报告 | 2021-10-29 |
| 2021-11-04 | 12201.12 | 未披露 |
更多>>
From June 30, 2021 to September 30, 2021
Issuances under equity incentive plans
Vesting of restricted stock units
|
2021-09-30 |
| 2021-08-04 | 12164.01 | 未披露 | 定期报告 | 2021-07-28 |
| 2021-08-04 | 12153.20 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Issuances under equity incentive plans
Vesting of restricted stock units
|
2021-06-30 |
| 2021-05-05 | 12119.22 | 未披露 | 定期报告 | 2021-04-26 |
| 2021-04-22 | 12117.70 | 未披露 | 定期报告 | 2021-04-12 |
| 2021-05-05 | 12114.74 | 未披露 |
更多>>
from December 31, 2020 to March 31, 2021
Issuances under equity incentive plans
Vesting of restricted stock units
|
2021-03-31 |
| 2021-02-26 | 12098.41 | 未披露 | 定期报告 | 2021-02-17 |
| 2021-02-26 | 12053.13 | 未披露 |
更多>>
From December 31, 2019 to December 31, 2020
Issuance of common stock in follow-on offering, net of issuance costs of $632
Issuance of common stock in connection with the Biogen Stock Purchase Agreement
Issuances under equity incentive plans
Vesting of restricted stock units
|
2020-12-31 |
| 2020-11-05 | 11991.85 | 未披露 | 定期报告 | 2020-10-28 |
| 2020-11-05 | 11979.52 | 未披露 |
更多>>
From June 30, 2020 to September 30, 2020
Issuance of common stock in connection with the Biogen Stock Purchase Agreement
Issuances under equity incentive plans
Vesting of restricted stock units
|
2020-09-30 |
| 2020-08-07 | 10598.31 | 未披露 | 定期报告 | 2020-08-03 |
| 2020-08-07 | 10589.79 | 未披露 |
更多>>
From March 31, 2020 to June 30, 2020
Issuances under equity incentive plans
Vesting of restricted stock units
|
2020-06-30 |
| 2020-05-07 | 10562.82 | 未披露 | 定期报告 | 2020-04-29 |
| 2020-04-22 | 10560.54 | 未披露 | 定期报告 | 2020-04-13 |
| 2020-05-07 | 10554.13 | 未披露 |
更多>>
From December 31, 2019 to March 31, 2020
Issuance of common stock in follow-on offering, net of issuance costs of $632
Issuances under equity incentive plans
Vesting of restricted stock units
|
2020-03-31 |
| 2020-02-27 | 10542.33 | 未披露 | 定期报告 | 2020-02-19 |
| 2020-01-31 | 10382.41 | 未披露 | 定期报告 | 2020-01-31 |
| 2020-02-27 | 9618.99 | 未披露 |
更多>>
From December 31, 2018 to December 31, 2019
Issuances under equity incentive plans
Vesting of early exercised common stock
Vesting of restricted stock units
|
2019-12-31 |
| 2019-11-06 | 9603.12 | 未披露 | 定期报告 | 2019-10-30 |
| 2019-11-06 | 9598.76 | 未披露 |
更多>>
from June 30, 2019 to September 30, 2019
Issuances under equity incentive plans
Vesting of early exercised common stock
Vesting of restricted stock units
|
2019-09-30 |
| 2019-08-06 | 9584.16 | 未披露 | 定期报告 | 2019-07-31 |
| 2019-08-06 | 9565.69 | 未披露 |
更多>>
From March 31, 2019 to June 30, 2019
Issuances under equity incentive plans
Vesting of early exercised common stock
Vesting of restricted stock awards
|
2019-06-30 |
| 2019-05-08 | 9547.84 | 未披露 | 定期报告 | 2019-05-01 |
| 2019-04-18 | 9543.79 | 未披露 | 定期报告 | 2019-04-11 |
| 2019-05-08 | 9525.77 | 未披露 |
更多>>
from December 31, 2018 to March 31, 2019
Issuances under equity incentive plans
Vesting of early exercised common stock
Vesting of restricted stock awards
|
2019-03-31 |
| 2019-03-12 | 9528.90 | 未披露 | 定期报告 | 2019-03-05 |
| 2019-03-12 | 9466.24 | 未披露 |
更多>>
from December 31, 2017 to December 31, 2018
Issuance of common stock in connection with the Takeda Collaboration Agreement
Issuances under equity incentive plans
Vesting of early exercised common stock
Vesting of restricted stock awards
|
2018-12-31 |
| 2018-11-08 | 9495.71 | 未披露 | 定期报告 | 2018-11-02 |
| 2018-11-08 | 9397.37 | 未披露 | 定期报告 | 2018-09-30 |
| 2018-08-09 | 9480.71 | 未披露 | 定期报告 | 2018-08-02 |
| 2018-08-09 | 9332.17 | 未披露 | 定期报告 | 2018-06-30 |
| 2018-05-11 | 9444.19 | 未披露 | 定期报告 | 2018-05-04 |
| 2018-04-26 | 9444.18 | 未披露 | 定期报告 | 2018-04-18 |
| 2018-05-11 | 8748.04 | 未披露 | 定期报告 | 2018-03-31 |
| 2018-03-19 | 9442.92 | 未披露 | 定期报告 | 2018-03-12 |
| 2018-03-19 | 8748.04 | 未披露 |
更多>>
from December 31, 2016 to December 31, 2017
Issuance of series B-2 convertible preferred stock for cash, net of issuance costs of $73
Conversion of Series A and B convertible preferred stock into common stock
Issuance of common stock upon initial public offering, net of issuance costs of $23,612
Issuance of common stock upon exercise of stock options
Issuance of reserved common stock as consideration in asset acquisition
Vesting of early exercised common stock
Vesting of restricted stock awards
|
2017-12-31 |
| 2017-12-08 | 8797.95 | 未披露 |
更多>>
1.Common stock offered 13,888,888 shares
2.The number of shares of our common stock to be outstanding after this offering is based on the 74,090,587 shares of our common stock outstanding as of September 30, 2017 (including convertible preferred stock on an as-converted basis, as well as 1,764,705 shares of our Series B-2 convertible preferred stock issued after September 30, 2017)
3.a 4-for-1 reverse stock split of our common stock and convertible preferred stock effected on November 28, 2017
|
2017-12-08 |
| 2017-11-27 | 7409.06 | 未披露 |
更多>>
the percentage based on 74,090,587 shares of our common stock outstanding as of November 24, 2017, which includes 60,365,020 shares of our common stock resulting from the conversion of all outstanding shares of our convertible preferred stock (including our Series B-2 convertible preferred stock issued in November 2017) into our common stock immediately prior to the completion of this offering, as if this conversion had occurred as of November 24, 2017.
|
2017-11-24 |
| 2017-11-13 | 28930.40 | 未披露 | 定期报告 | 2017-09-30 |
From March 31, 2026 to June 30,2026
Issuances under equity incentive plans
Vesting of restricted stock units
From December 31, 2025 to March 31, 2026
Issuance of common stock, net of issuance cost of $45
Issuances under equity incentive plans
Vesting of restricted stock units
From December 31, 2024 to December 31, 2025
Issuance of common stock and pre-funded warrants, net of issuance costs of $728
Issuances under equity incentive plans
Vesting of restricted stock units
Common Stock offered 9,142,857 shares by the company
From June 30, 2025 to September 30, 2025
Issuances under equity incentive plans
Vesting of restricted stock units
Stock-based compensation
From March 31, 2025 to June 30, 2025
Issuances under equity incentive plans
Vesting of restricted stock units
From December 31, 2024 to March 31, 2025
Issuances under equity incentive plans
Vesting of restricted stock units
From December 31, 2023 to December 31, 2024
Issuance of common stock and pre-funded warrants, net of issuance costs of $480
Issuances under equity incentive plans
Vesting of restricted stock units
From June 30, 2024 to September 30, 2024
Issuances under equity incentive plans
Vesting of restricted stock units
From March 31, 2024 to June 30, 2024
Issuances under equity incentive plans
Vesting of restricted stock units
From December 31, 2023 to March 31, 2024
Issuance of common stock and pre-funded warrants, net of issuance costs of $480K
Issuances under equity incentive plans
Vesting of restricted stock units
From December 31, 2022 to December 31, 2023
Issuances under equity incentive plans
Vesting of restricted stock units
From June 30, 2023 to September 30, 2023
Issuances under equity incentive plans
Vesting of restricted stock units
From December 31, 2022 to March 31, 2023
Issuances under equity incentive plans
Vesting of restricted stock units
From December 31, 2021 to December 31, 2022
Issuances under equity incentive plans
Vesting of restricted stock units
Issuance of common stock in follow-on offering, net of issuance costs of $1,060
Common stock offered 10,377,359 shares by the company
From June 30, 2022 to September 30, 2022
Issuances under equity incentive plans
Vesting of restricted stock units
From March 31, 2022 to June 30, 2022
Issuances under equity incentive plans
Vesting of restricted stock units
From December 31, 2021 to March 31, 2022
Issuances under equity incentive plans
Vesting of restricted stock units
From December 31, 2020 to December 31, 2021
Issuances under equity incentive plans
Vesting of restricted stock awards
From June 30, 2021 to September 30, 2021
Issuances under equity incentive plans
Vesting of restricted stock units
From March 31, 2021 to June 30, 2021
Issuances under equity incentive plans
Vesting of restricted stock units
from December 31, 2020 to March 31, 2021
Issuances under equity incentive plans
Vesting of restricted stock units
From December 31, 2019 to December 31, 2020
Issuance of common stock in follow-on offering, net of issuance costs of $632
Issuance of common stock in connection with the Biogen Stock Purchase Agreement
Issuances under equity incentive plans
Vesting of restricted stock units
From June 30, 2020 to September 30, 2020
Issuance of common stock in connection with the Biogen Stock Purchase Agreement
Issuances under equity incentive plans
Vesting of restricted stock units
From March 31, 2020 to June 30, 2020
Issuances under equity incentive plans
Vesting of restricted stock units
From December 31, 2019 to March 31, 2020
Issuance of common stock in follow-on offering, net of issuance costs of $632
Issuances under equity incentive plans
Vesting of restricted stock units
From December 31, 2018 to December 31, 2019
Issuances under equity incentive plans
Vesting of early exercised common stock
Vesting of restricted stock units
from June 30, 2019 to September 30, 2019
Issuances under equity incentive plans
Vesting of early exercised common stock
Vesting of restricted stock units
From March 31, 2019 to June 30, 2019
Issuances under equity incentive plans
Vesting of early exercised common stock
Vesting of restricted stock awards
from December 31, 2018 to March 31, 2019
Issuances under equity incentive plans
Vesting of early exercised common stock
Vesting of restricted stock awards
from December 31, 2017 to December 31, 2018
Issuance of common stock in connection with the Takeda Collaboration Agreement
Issuances under equity incentive plans
Vesting of early exercised common stock
Vesting of restricted stock awards
from December 31, 2016 to December 31, 2017
Issuance of series B-2 convertible preferred stock for cash, net of issuance costs of $73
Conversion of Series A and B convertible preferred stock into common stock
Issuance of common stock upon initial public offering, net of issuance costs of $23,612
Issuance of common stock upon exercise of stock options
Issuance of reserved common stock as consideration in asset acquisition
Vesting of early exercised common stock
Vesting of restricted stock awards
1.Common stock offered 13,888,888 shares
2.The number of shares of our common stock to be outstanding after this offering is based on the 74,090,587 shares of our common stock outstanding as of September 30, 2017 (including convertible preferred stock on an as-converted basis, as well as 1,764,705 shares of our Series B-2 convertible preferred stock issued after September 30, 2017)
3.a 4-for-1 reverse stock split of our common stock and convertible preferred stock effected on November 28, 2017
the percentage based on 74,090,587 shares of our common stock outstanding as of November 24, 2017, which includes 60,365,020 shares of our common stock resulting from the conversion of all outstanding shares of our convertible preferred stock (including our Series B-2 convertible preferred stock issued in November 2017) into our common stock immediately prior to the completion of this offering, as if this conversion had occurred as of November 24, 2017.