股本结构
单位：万股
| 公告日期 | 2024-03-20 | 2024-03-27 | 2024-03-27 | 2024-02-28 | 2024-02-28 | 2023-11-02 |
|---|---|---|---|---|---|---|
| 证券总股本 | 58805.93 | 54687.39 | 54612.39 | 54605.93 | 54491.22 | 54306.40 |
| 普通股本 | 58805.93 | 54687.39 | 54612.39 | 54605.93 | 54491.22 | 54306.40 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2024-03-21 | 2024-03-12 | 2024-03-01 | 2024-02-23 | 2023-12-31 | 2023-10-31 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2024-03-20 | 58805.93 | 未披露 |
更多>>
Common stock offered 41,999,998 shares by the company
|
2024-03-21 |
| 2024-03-27 | 54687.39 | 未披露 | 定期报告 | 2024-03-12 |
| 2024-03-27 | 54612.39 | 未披露 | 定期报告 | 2024-03-01 |
| 2024-02-28 | 54605.93 | 未披露 | 定期报告 | 2024-02-23 |
| 2024-02-28 | 54491.22 | 未披露 |
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From December 31, 2022 to December 31, 2023
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuances of common stock under equity plans
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs of $14,507
Issuance of common stock in connection with exercise of warrants
|
2023-12-31 |
| 2023-11-02 | 54306.40 | 未披露 | 定期报告 | 2023-10-31 |
| 2023-11-02 | 54247.97 | 未披露 |
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From June 30, 2023 to September 30, 2023
Issuance of common stock in connection with exercise of warrants
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock under equity plans
|
2023-09-30 |
| 2023-08-03 | 52337.07 | 未披露 | 定期报告 | 2023-07-27 |
| 2023-08-03 | 52194.21 | 未披露 |
更多>>
From March 31, 2023 to June 30, 2023
Issuance of common stock in connection with exercise of warrants
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock under equity plans
|
2023-06-30 |
| 2023-05-11 | 50876.68 | 未披露 | 定期报告 | 2023-05-05 |
| 2023-04-12 | 50873.18 | 未披露 | 定期报告 | 2023-04-06 |
| 2023-03-16 | 50872.25 | 未披露 | 定期报告 | 2023-03-09 |
| 2023-01-06 | 43711.13 | 未披露 |
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Common stock offered 55,876,297 shares by the company
|
2023-01-10 |
| 2023-03-16 | 39026.25 | 未披露 |
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From December 31, 2021 to December 31, 2022
Issuance of common stock in connection with exercise of warrants
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs of $5,066
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuances of common stock under equity plans
|
2022-12-31 |
| 2022-11-07 | 38123.50 | 未披露 |
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From June 30, 2022 to September 30, 2022
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock in connection with exercise of warrants
Issuances of common stock under equity plans
|
2022-09-30 |
| 2022-08-11 | 37781.89 | 未披露 | 定期报告 | 2022-08-05 |
| 2022-08-11 | 37766.48 | 未披露 |
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From March 31, 2022 to June 30, 2022
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs of $5,066
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuances of common stock under equity plans
|
2022-06-30 |
| 2022-05-09 | 37744.71 | 未披露 | 定期报告 | 2022-05-03 |
| 2022-04-01 | 37706.49 | 未披露 |
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1.Common stock offered by 53,333,334 shares.
2.The number of shares of common stock to be outstanding immediately after this offering as shown above is based on 323,731,591 shares of common stock outstanding as of December 31, 2021.
|
2022-04-01 |
| 2022-05-09 | 32373.69 | 未披露 |
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From December 31, 2021 to March 31, 2022
Stock-based compensation related to issuance of common stock and options in exchange for services
|
2022-03-31 |
| 2022-03-10 | 32373.16 | 未披露 |
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From December 31, 2020 to December 31, 2021
Issuance of common stock in connection with at market offering, net of issuance costs of $470
Issuance of common stock in connection with exercise of warrants
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuances of common stock under equity plans
|
2021-12-31 |
| 2021-11-09 | 32194.90 | 未披露 | 定期报告 | 2021-11-04 |
| 2021-11-09 | 32060.44 | 未披露 |
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From June 30, 2021 to September 30, 2021
Stock-based compensation related to issuance of common stock and options in exchange for services
|
2021-09-30 |
| 2021-08-16 | 32059.92 | 未披露 |
更多>>
From March 31, 2021 to June 30, 2021
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock in connection with exercise of warrants
Issuance of common stock under equity plans
|
2021-06-30 |
| 2021-05-10 | 31856.75 | 未披露 | 定期报告 | 2021-05-04 |
| 2021-05-10 | 31854.50 | 未披露 |
更多>>
From December 31, 2020 to March 31, 2021
Issuance of common stock in connection with at market offering, net of issuance costs of $374
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock in connection with exercise of warrants
Issuance of common stock under equity plans
|
2021-03-31 |
| 2021-03-22 | 31853.07 | 未披露 | 定期报告 | 2021-03-18 |
| 2021-03-11 | 31852.75 | 未披露 | 定期报告 | 2021-03-01 |
| 2021-03-11 | 31056.69 | 未披露 |
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From December 31, 2019 to December 31, 2020
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs of $9,808
Issuance of common stock in connection with at market offering, net of issuance costs of $144
Issuance of common stock in connection exercise of warrants
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuances of common stock under equity plans
|
2020-12-31 |
| 2020-11-05 | 31047.22 | 未披露 | 定期报告 | 2020-11-02 |
| 2020-11-05 | 31047.11 | 未披露 |
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From June 30, 2020 to September 30, 2020
Issuance of common stock in connection exercise of warrants
Issuance of common stock under equity plans
Stock-based compensation related to issuance of common stock and options in exchange for services
|
2020-09-30 |
| 2020-08-06 | 31046.69 | 未披露 | 定期报告 | 2020-07-31 |
| 2020-08-06 | 31044.24 | 未披露 |
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from March 31, 2020 to June 30, 2020
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering,net of issuance costs of $9,808
Issuance of common stock in connection with at market offering, net of issuance costs of $68
Issuance of common stock under equity plans
Stock-based compensation related to issuance of common stock and options in exchange for services
|
2020-06-30 |
| 2020-05-27 | 30686.40 | 未披露 |
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1.Common stock offered 107,049,375 shares
2.The number of shares of our common stock to be outstanding immediately after this offering as shown above is based on 199,814,581 shares of common stock outstanding as of December 31, 2019
|
2020-05-27 |
| 2020-05-28 | 20331.72 | 未披露 | 定期报告 | 2020-05-22 |
| 2020-04-14 | 20036.18 | 未披露 | 定期报告 | 2020-04-09 |
| 2020-05-28 | 20035.08 | 未披露 |
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from December 31, 2019 to March 31, 2020
Issuance of common stock in connection with at market offering, net of issuance costs of $76
Stock-based compensation related to issuance of common stock and options in exchange for services
|
2020-03-31 |
| 2020-03-12 | 20034.48 | 未披露 | 定期报告 | 2020-03-02 |
| 2020-03-12 | 19981.46 | 未披露 |
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from December 31, 2018 to December 31, 2019
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock in connection with at market offering, net of issuance costs of $481
Issuances of common stock under equity plans
|
2019-12-31 |
| 2019-11-06 | 19977.76 | 未披露 | 定期报告 | 2019-11-01 |
| 2019-11-06 | 19286.51 | 未披露 |
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from June 30, 2019 to September 30, 2019
Issuance of common stock in connection with at market offering, net of issuance costs of $207
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock under equity plans
|
2019-09-30 |
| 2019-08-01 | 18842.31 | 未披露 | 定期报告 | 2019-07-26 |
| 2019-08-01 | 18663.84 | 未披露 |
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from March 31, 2019 to June 30, 2019
Issuance of common stock in connection with at market offering, net of issuance costs of $73
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock under equity plans
|
2019-06-30 |
| 2019-05-02 | 18651.60 | 未披露 | 定期报告 | 2019-04-29 |
| 2019-04-22 | 18645.60 | 未披露 | 定期报告 | 2019-04-08 |
| 2019-05-02 | 18640.60 | 未披露 |
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from December 31, 2018 to March 31, 2019
Stock-based compensation related to issuance of common stock and options in exchange for services
|
2019-03-31 |
| 2019-03-07 | 18639.27 | 未披露 |
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from December 31, 2017 to December 31, 2018
Issuance of common stock in connection with at market offering, net of issuance costs of $2,282
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuances of common stock under equity plans
|
2018-12-31 |
| 2018-11-01 | 18634.81 | 未披露 | 定期报告 | 2018-09-30 |
| 2018-07-31 | 18362.20 | 未披露 | 定期报告 | 2018-07-24 |
| 2018-07-31 | 18254.71 | 未披露 | 定期报告 | 2018-06-30 |
| 2018-05-10 | 17308.07 | 未披露 | 定期报告 | 2018-04-30 |
| 2018-07-10 | 16066.23 | 未披露 | 定期报告 | 2018-03-31 |
| 2018-03-16 | 16065.40 | 未披露 | 定期报告 | 2018-03-07 |
| 2018-03-16 | 15987.72 | 未披露 |
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from December 31, 2016 to December 31, 2017
Issuance of common stock in connection with at market offering, net of issuance costs of $114
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuances of common stock under equity plans
|
2017-12-31 |
| 2017-11-01 | 15923.18 | 未披露 | 定期报告 | 2017-10-25 |
| 2017-08-09 | 15921.36 | 未披露 | 定期报告 | 2017-08-02 |
| 2017-05-09 | 15917.61 | 未披露 | 定期报告 | 2017-03-31 |
| 2017-03-01 | 15915.86 | 未披露 |
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From December 31, 2015 to December 31, 2016
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuances of common stock under equity plans
|
2016-12-31 |
| 2016-11-03 | 15914.51 | 未披露 | 定期报告 | 2016-09-30 |
| 2016-08-03 | 15913.93 | 未披露 | 定期报告 | 2016-06-30 |
| 2016-05-05 | 15896.03 | 未披露 | 定期报告 | 2016-04-29 |
| 2016-05-05 | 15892.93 | 未披露 | 定期报告 | 2016-03-31 |
| 2016-03-10 | 15891.68 | 未披露 | 定期报告 | 2016-03-03 |
| 2016-03-10 | 15878.14 | 未披露 |
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from December 31, 2014 to December 31, 2015
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock upon exercise of warrants
Issuances of common stock under equity plans, net of cancellations of non-vested restricted stock
|
2015-12-31 |
| 2015-11-05 | 15822.19 | 未披露 | 定期报告 | 2015-09-30 |
| 2015-08-05 | 15814.22 | 未披露 | 定期报告 | 2015-07-31 |
| 2015-08-05 | 15812.29 | 未披露 | 定期报告 | 2015-06-30 |
| 2015-05-07 | 15808.75 | 未披露 | 定期报告 | 2015-04-30 |
| 2015-05-07 | 15808.43 | 未披露 | 定期报告 | 2015-03-31 |
| 2015-04-03 | 15784.58 | 未披露 | 定期报告 | 2015-03-23 |
| 2015-03-11 | 15770.04 | 未披露 | 定期报告 | 2015-03-06 |
| 2015-03-11 | 15742.99 | 未披露 |
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From December 31,2013 to December 31,2014
Issuance of common stock in connection with public offering, net of issuance costs of $6,695
Stock-based compensation related to issuance of common stock and options in exchange for services
Cancellations of non-vested restricted stock under equity plans, net of issuances of common stock
401(k) contribution
|
2014-12-31 |
| 2014-11-05 | 15721.15 | 未披露 | 定期报告 | 2014-10-31 |
| 2014-11-05 | 15693.41 | 未披露 | 定期报告 | 2014-09-30 |
| 2014-08-11 | 15688.35 | 未披露 | 定期报告 | 2014-08-04 |
| 2014-08-11 | 15686.18 | 未披露 | 定期报告 | 2014-06-30 |
| 2014-05-01 | 15693.83 | 未披露 | 定期报告 | 2014-04-25 |
| 2014-05-01 | 15692.79 | 未披露 | 定期报告 | 2014-03-31 |
| 2014-03-17 | 15689.89 | 未披露 | 定期报告 | 2014-03-06 |
| 2014-03-17 | 13067.79 | 未披露 |
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From December 31,2012 to December 31,2013
Stock-based compensation related to issuance of common stock and options in exchange for services
Cancellations of non-vested restricted stock under equity plans, net of issuances of common stock
401(k) contribution
|
2013-12-31 |
| 2013-11-07 | 12896.74 | 未披露 | 定期报告 | 2013-11-01 |
| 2013-11-07 | 12894.95 | 未披露 | 定期报告 | 2013-09-30 |
| 2013-08-08 | 12864.94 | 未披露 | 定期报告 | 2013-08-01 |
| 2013-08-08 | 12989.59 | 未披露 | 定期报告 | 2013-06-30 |
| 2013-05-03 | 13042.98 | 未披露 | 定期报告 | 2013-04-29 |
| 2013-05-03 | 13043.45 | 未披露 | 定期报告 | 2013-03-31 |
| 2013-04-05 | 13057.33 | 未披露 | 定期报告 | 2013-03-25 |
| 2013-03-15 | 13057.47 | 未披露 | 定期报告 | 2013-03-01 |
| 2013-03-15 | 13024.27 | 未披露 |
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from December 31, 2011 to December 31, 2012
Stock-based compensation related to issuance of common stock and options in exchange for services
Cancellation of non-vested restricted stock under equity plans, net of issuances of common stock
401(k) contribution
|
2012-12-31 |
| 2012-11-02 | 13075.56 | 未披露 | 定期报告 | 2012-09-30 |
| 2012-08-03 | 13125.82 | 未披露 | 定期报告 | 2012-07-30 |
| 2012-07-03 | 13131.59 | 未披露 | 定期报告 | 2012-06-30 |
| 2012-05-07 | 13208.58 | 未披露 | 定期报告 | 2012-04-30 |
| 2012-03-07 | 13248.89 | 未披露 | 定期报告 | 2012-02-22 |
| 2012-03-07 | 13144.31 | 未披露 |
更多>>
from December 31, 2010 to December 31, 2011
Issuance of common stock in connection with acquired in-process research technology
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock under employee stock plans, net
401(k) contribution
|
2011-12-31 |
| 2011-11-03 | 13147.36 | 未披露 | 定期报告 | 2011-10-24 |
| 2011-08-05 | 13142.60 | 未披露 | 定期报告 | 2011-07-25 |
| 2011-04-29 | 12899.14 | 未披露 | 定期报告 | 2011-04-25 |
| 2011-02-25 | 12878.11 | 未披露 | 定期报告 | 2011-02-22 |
| 2011-02-25 | 12261.67 | 未披露 |
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From December 31, 2009 to December 31, 2010
Issuance of common stock in connection with public offering, net of issuance costs of $6,300
Issuance of common stock in connection with private offering, net of issuance costs of $44
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock under employee stock plans, net
401(k) contribution
|
2010-12-31 |
| 2010-10-29 | 10258.72 | 未披露 | 定期报告 | 2010-10-25 |
| 2010-07-30 | 10192.66 | 未披露 | 定期报告 | 2010-07-26 |
| 2010-04-30 | 9818.15 | 未披露 | 定期报告 | 2010-04-26 |
| 2010-02-26 | 9745.55 | 未披露 | 定期报告 | 2010-02-23 |
| 2010-02-26 | 9252.19 | 未披露 |
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From December 31, 2008 to December 31, 2009
Issuance of common stock in connection with public offering, net of issuance costs of $1,916
Issuance of common stock in connection with private offering, net of issuance costs of $18
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock under employee stock plans, net
401(k) contribution
|
2009-12-31 |
| 2009-02-27 | 8900.90 | 未披露 | 定期报告 | 2009-02-23 |
| 2009-02-27 | 8107.05 | 未披露 |
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From December 31, 2007 to December 31, 2008
Stock-based compensation related to issuance of common stock in exchange for services
Issuance of common stock under employee stock plans, net
401(k) contribution
|
2008-12-31 |
| 2008-02-28 | 7647.30 | 未披露 | 定期报告 | 2008-02-22 |
| 2008-02-28 | 7606.24 | 未披露 |
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From December 31, 2006 to December 31, 2007
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock upon exercise of warrants
Issuance of common stock under employee stock plans, net
401(k) contribution
|
2007-12-31 |
| 2007-03-16 | 7286.61 | 未披露 | 定期报告 | 2007-03-02 |
| 2007-03-16 | 7044.91 | 未披露 |
更多>>
From December 31, 2005 to December 31, 2006
Issuance of common stock and warrants in connection with private financing, net of issuance costs of $61
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock upon exercise of warrants
Issuance of common stock under employee stock plans, net
401(k) contribution
|
2006-12-31 |
| 2006-03-01 | 6508.65 | 未披露 | 定期报告 | 2006-02-13 |
| 2006-03-01 | 6482.99 | 未披露 |
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From December 31, 2004 to December 31, 2005
Issuance of common stock and warrants in connection with private financing, net of issuance costs of $1,641
Issuance of common stock in connection with public offering, net of issuance costs of $4,115
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock upon exercise of warrants
Issuance of common stock under employee stock plans, net
401(k) contribution
|
2005-12-31 |
| 2005-02-28 | 5456.80 | 未披露 | 定期报告 | 2005-02-18 |
| 2005-02-28 | 5222.03 | 未披露 |
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From December 31, 2003 to December 31, 2004
Issuance of common stock and warrants in connection with private financing, net of issuance costs of $12,792
Issuance of common stock in acquisition of technology
Stock-based compensation related to issuance of common stock and options in exchange for services and prepaid facility rent
Issuance of common stock upon exercise of warrants
Issuance of common stock under employee stock plans, net
401(k) contribution
|
2004-12-31 |
| 2004-02-27 | 3931.67 | 未披露 |
更多>>
From December 31, 2002 to December 31, 2003
Issuance of common stock in connection with private financings, net of issuance costs of $1,260
Issuance of common stock in connection with public offering, net of issuance costs of $10,849
Conversion of convertible debentures
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock upon exercise of warrants
Issuance of common stock under employee stock plans, net
401(k) contribution
|
2003-12-31 |
| 2003-03-03 | 2491.92 | 未披露 | 定期报告 | 2003-02-27 |
| 2003-03-03 | 2476.68 | 未披露 |
更多>>
From December 31, 2001 to December 31, 2002
Issuance of common stock in acquisition of technology
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock under employee stock plans, net
|
2002-12-31 |
| 2002-03-01 | 2449.18 | 未披露 | 定期报告 | 2002-02-25 |
| 2002-03-01 | 2448.18 | 未披露 |
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From December 31, 2000 to December 31, 2001
Issuance of common stock in connection with equity line
Conversion of convertible debentures
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock to certain research institutions
Issuance of common stock upon exercise of warrants
Issuance of common stock under employee stock plans, net
|
2001-12-31 |
| 2001-03-23 | 2178.14 | 未披露 | 定期报告 | 2001-03-05 |
| 2001-03-23 | 2178.08 | 未披露 |
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From December 31, 1999 to December 31, 2000
Issuance of common stock in connection with equity line less issuance costs of $9
Issuance of common stock in connection with private investor financing
Conversion of convertible debentures
Issuance of common stock in exchange for services
Issuance of common stock to certain research institutions
Issuance of common stock upon exercise of warrants
Issuance of common stock under employee stock plans, net
|
2000-12-31 |
| 2000-03-13 | 1860.71 | 未披露 | 定期报告 | 2000-03-07 |
| 2000-03-13 | 1738.11 | 未披露 |
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From December 31, 1998 to December 31, 1999
Issuance of common stock in connection with acquisition
Conversion of convertible debentures
Issuance of common stock in exchange for services
Issuance of common stock to certain research institutions, net of issuance costs of $5
Issuance of common stock upon exercise of warrants
Issuance of common stock under employee stock plans, net
|
1999-12-31 |
| 1999-03-16 | 1366.62 | 未披露 | 定期报告 | 1999-03-08 |
| 1999-03-16 | 1366.13 | 0.35 |
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From December 31, 1997 to December 31, 1998
Issuance of common stock in connection with corporate collaboration
Issuance of convertible preferred stock,net of issuance costs of $72
Conversion of convertible preferred stock into common stock
Issuance of common stock in exchange for services
Issuance of common stock under employee stock plans
Transfer remaining shares of convertible preferred stock to redeemable convertible preferred stock
|
1998-12-31 |
| 1998-03-31 | 1088.76 | 未披露 | 定期报告 | 1998-03-25 |
| 1998-03-31 | 1079.59 | 未披露 |
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From December 31, 1996 to December 31, 1997
Issuance of common stock in connection with corporate collaboration, net of issuance costs of $9
Issuance of common stock in exchange for services
Issuance of common stock to certain research institutions
Issuance of common stock upon exercise of options, net
Issuance of common stock under stock purchase plan
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1997-12-31 |
| 1997-03-20 | 1021.38 | 未披露 | 定期报告 | 1997-03-14 |
| 1997-03-20 | 1004.04 | 未披露 |
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From December 31, 1995 to December 31, 1996
Issuance of preferred stock, net of issuance costs of $13
Issuance of common stock upon exercise of options, net
Issuance of common stock upon exercise of warrants
Issuance of preferred and common stock, net of issuance costs of $2,050, in connection with the Company's Initial Public Offering
Conversion of preferred stock to common stock in connection with the Company's IPO
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1996-12-31 |
Common stock offered 41,999,998 shares by the company
From December 31, 2022 to December 31, 2023
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuances of common stock under equity plans
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs of $14,507
Issuance of common stock in connection with exercise of warrants
From June 30, 2023 to September 30, 2023
Issuance of common stock in connection with exercise of warrants
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock under equity plans
From March 31, 2023 to June 30, 2023
Issuance of common stock in connection with exercise of warrants
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock under equity plans
Common stock offered 55,876,297 shares by the company
From December 31, 2021 to December 31, 2022
Issuance of common stock in connection with exercise of warrants
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs of $5,066
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuances of common stock under equity plans
From June 30, 2022 to September 30, 2022
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock in connection with exercise of warrants
Issuances of common stock under equity plans
From March 31, 2022 to June 30, 2022
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs of $5,066
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuances of common stock under equity plans
1.Common stock offered by 53,333,334 shares.
2.The number of shares of common stock to be outstanding immediately after this offering as shown above is based on 323,731,591 shares of common stock outstanding as of December 31, 2021.
From December 31, 2021 to March 31, 2022
Stock-based compensation related to issuance of common stock and options in exchange for services
From December 31, 2020 to December 31, 2021
Issuance of common stock in connection with at market offering, net of issuance costs of $470
Issuance of common stock in connection with exercise of warrants
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuances of common stock under equity plans
From June 30, 2021 to September 30, 2021
Stock-based compensation related to issuance of common stock and options in exchange for services
From March 31, 2021 to June 30, 2021
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock in connection with exercise of warrants
Issuance of common stock under equity plans
From December 31, 2020 to March 31, 2021
Issuance of common stock in connection with at market offering, net of issuance costs of $374
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock in connection with exercise of warrants
Issuance of common stock under equity plans
From December 31, 2019 to December 31, 2020
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs of $9,808
Issuance of common stock in connection with at market offering, net of issuance costs of $144
Issuance of common stock in connection exercise of warrants
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuances of common stock under equity plans
From June 30, 2020 to September 30, 2020
Issuance of common stock in connection exercise of warrants
Issuance of common stock under equity plans
Stock-based compensation related to issuance of common stock and options in exchange for services
from March 31, 2020 to June 30, 2020
Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering,net of issuance costs of $9,808
Issuance of common stock in connection with at market offering, net of issuance costs of $68
Issuance of common stock under equity plans
Stock-based compensation related to issuance of common stock and options in exchange for services
1.Common stock offered 107,049,375 shares
2.The number of shares of our common stock to be outstanding immediately after this offering as shown above is based on 199,814,581 shares of common stock outstanding as of December 31, 2019
from December 31, 2019 to March 31, 2020
Issuance of common stock in connection with at market offering, net of issuance costs of $76
Stock-based compensation related to issuance of common stock and options in exchange for services
from December 31, 2018 to December 31, 2019
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock in connection with at market offering, net of issuance costs of $481
Issuances of common stock under equity plans
from June 30, 2019 to September 30, 2019
Issuance of common stock in connection with at market offering, net of issuance costs of $207
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock under equity plans
from March 31, 2019 to June 30, 2019
Issuance of common stock in connection with at market offering, net of issuance costs of $73
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock under equity plans
from December 31, 2018 to March 31, 2019
Stock-based compensation related to issuance of common stock and options in exchange for services
from December 31, 2017 to December 31, 2018
Issuance of common stock in connection with at market offering, net of issuance costs of $2,282
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuances of common stock under equity plans
from December 31, 2016 to December 31, 2017
Issuance of common stock in connection with at market offering, net of issuance costs of $114
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuances of common stock under equity plans
From December 31, 2015 to December 31, 2016
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuances of common stock under equity plans
from December 31, 2014 to December 31, 2015
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock upon exercise of warrants
Issuances of common stock under equity plans, net of cancellations of non-vested restricted stock
From December 31,2013 to December 31,2014
Issuance of common stock in connection with public offering, net of issuance costs of $6,695
Stock-based compensation related to issuance of common stock and options in exchange for services
Cancellations of non-vested restricted stock under equity plans, net of issuances of common stock
401(k) contribution
From December 31,2012 to December 31,2013
Stock-based compensation related to issuance of common stock and options in exchange for services
Cancellations of non-vested restricted stock under equity plans, net of issuances of common stock
401(k) contribution
from December 31, 2011 to December 31, 2012
Stock-based compensation related to issuance of common stock and options in exchange for services
Cancellation of non-vested restricted stock under equity plans, net of issuances of common stock
401(k) contribution
from December 31, 2010 to December 31, 2011
Issuance of common stock in connection with acquired in-process research technology
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock under employee stock plans, net
401(k) contribution
From December 31, 2009 to December 31, 2010
Issuance of common stock in connection with public offering, net of issuance costs of $6,300
Issuance of common stock in connection with private offering, net of issuance costs of $44
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock under employee stock plans, net
401(k) contribution
From December 31, 2008 to December 31, 2009
Issuance of common stock in connection with public offering, net of issuance costs of $1,916
Issuance of common stock in connection with private offering, net of issuance costs of $18
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock under employee stock plans, net
401(k) contribution
From December 31, 2007 to December 31, 2008
Stock-based compensation related to issuance of common stock in exchange for services
Issuance of common stock under employee stock plans, net
401(k) contribution
From December 31, 2006 to December 31, 2007
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock upon exercise of warrants
Issuance of common stock under employee stock plans, net
401(k) contribution
From December 31, 2005 to December 31, 2006
Issuance of common stock and warrants in connection with private financing, net of issuance costs of $61
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock upon exercise of warrants
Issuance of common stock under employee stock plans, net
401(k) contribution
From December 31, 2004 to December 31, 2005
Issuance of common stock and warrants in connection with private financing, net of issuance costs of $1,641
Issuance of common stock in connection with public offering, net of issuance costs of $4,115
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock upon exercise of warrants
Issuance of common stock under employee stock plans, net
401(k) contribution
From December 31, 2003 to December 31, 2004
Issuance of common stock and warrants in connection with private financing, net of issuance costs of $12,792
Issuance of common stock in acquisition of technology
Stock-based compensation related to issuance of common stock and options in exchange for services and prepaid facility rent
Issuance of common stock upon exercise of warrants
Issuance of common stock under employee stock plans, net
401(k) contribution
From December 31, 2002 to December 31, 2003
Issuance of common stock in connection with private financings, net of issuance costs of $1,260
Issuance of common stock in connection with public offering, net of issuance costs of $10,849
Conversion of convertible debentures
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock upon exercise of warrants
Issuance of common stock under employee stock plans, net
401(k) contribution
From December 31, 2001 to December 31, 2002
Issuance of common stock in acquisition of technology
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock under employee stock plans, net
From December 31, 2000 to December 31, 2001
Issuance of common stock in connection with equity line
Conversion of convertible debentures
Stock-based compensation related to issuance of common stock and options in exchange for services
Issuance of common stock to certain research institutions
Issuance of common stock upon exercise of warrants
Issuance of common stock under employee stock plans, net
From December 31, 1999 to December 31, 2000
Issuance of common stock in connection with equity line less issuance costs of $9
Issuance of common stock in connection with private investor financing
Conversion of convertible debentures
Issuance of common stock in exchange for services
Issuance of common stock to certain research institutions
Issuance of common stock upon exercise of warrants
Issuance of common stock under employee stock plans, net
From December 31, 1998 to December 31, 1999
Issuance of common stock in connection with acquisition
Conversion of convertible debentures
Issuance of common stock in exchange for services
Issuance of common stock to certain research institutions, net of issuance costs of $5
Issuance of common stock upon exercise of warrants
Issuance of common stock under employee stock plans, net
From December 31, 1997 to December 31, 1998
Issuance of common stock in connection with corporate collaboration
Issuance of convertible preferred stock,net of issuance costs of $72
Conversion of convertible preferred stock into common stock
Issuance of common stock in exchange for services
Issuance of common stock under employee stock plans
Transfer remaining shares of convertible preferred stock to redeemable convertible preferred stock
From December 31, 1996 to December 31, 1997
Issuance of common stock in connection with corporate collaboration, net of issuance costs of $9
Issuance of common stock in exchange for services
Issuance of common stock to certain research institutions
Issuance of common stock upon exercise of options, net
Issuance of common stock under stock purchase plan
From December 31, 1995 to December 31, 1996
Issuance of preferred stock, net of issuance costs of $13
Issuance of common stock upon exercise of options, net
Issuance of common stock upon exercise of warrants
Issuance of preferred and common stock, net of issuance costs of $2,050, in connection with the Company's Initial Public Offering
Conversion of preferred stock to common stock in connection with the Company's IPO