IMDZ

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from December 31, 2017 to December 31, 2018 Issuance of common stock under stock-based compensation plans

from December 31, 2016 to December 31, 2017 Issuance of common stock at $4.10 per share upon completion of public offering, net of offering costs of $5,367 Issuance of common stock under stock-based compensation plans

On October 27, 2017, we completed an underwritten follow-on public offering of 22,425,000 shares of our common stock, inclusive of the full exercise by the underwriters of the 30-day option to purchase 2,925,000 additional shares, at a public offering price of $4.10 per share. We received estimated net proceeds of approximately $86.6 million, after deducting underwriting discounts and commissions, and estimated offering expenses totaling approximately $5.4 million.

From December 31, 2015 to December 31, 2016 Issuance of common stock at $6.25 per share upon completion of public offering, net of offering costs of $2,355 Exercise of stock options Issuance of common stock in connection with ESPP purchase

From December 31, 2014 to December 31, 2015 Issuance of common stock at $26.50 per share upon completion of public offering, net of issuance costs of $5,397 Exercise of stock options Issuance of common stock in connection with ESPP purchase

from December 31, 2013 to December 31, 2014 Conversion of convertible preferred stock to common stock Issuance of common stock at $12.00 per share upon completion of IPO, net of offering costs of $7,100 Issuance of common stock upon cash and net exercise of warrants for $12.00 per share Exercise of stock options a 1-for-8.175 reverse stock split of the company's common stock and convertible preferred stock effected on July 14, 2014

a 1-for-8.175 reverse stock split of the company's common stock and convertible preferred stock effected on July 14, 2014

a 1-for-8.175 reverse stock split of the company's common stock and convertible preferred stock effected on July 14, 2014; the conversion of all outstanding shares of the company's convertible preferred stock into an aggregate of 9,769,422 shares of the company's common stock immediately prior to the closing of this offering; the exercise at the closing of the offering, on a net issuance basis based on the initial public offering price of $12.00 per share, of warrants to purchase 1,975,532 shares of the company's Series C convertible preferred stock outstanding as of March 31, 2014, that the company issued in connection with a financing in October 2013, or the 2013 warrants, into 629,695 shares of the company's common stock upon conversion of the company's Series C convertible preferred stock issuable upon exercise of the 2013 warrants, at an exercise price of $8.18 per share, which will expire upon the closing of this offering if not exercised

from December 31, 2013 to July 15, 2014 Exercise of stock options (unaudited) a 1-for-8.175 reverse stock split of our common stock and convertible preferred stock effected on July 14, 2014

from December 31, 2013 to March 31, 2014 Exercise of stock options (unaudited)