PZRX

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from December 31, 2015 to December 31, 2016 Issuance of stock in initial public offering, net of $2,025 in offering costs Issuance of common stock to financial advisor, noncash Conversion of preferred stock Conversion of notes payable and related accrued interest Conversion of bridge loan and related accrued interest Cashless exercise of warrants Exercise of options

On May 23, 2016, we closed our IPO and sold 3,700,000 shares of common stock at a price of $5.00 per share to the public. The aggregate net proceeds received by us from the offering, net of underwriting discounts and commissions and offering expenses, were $16.5 million.

from December 31, 2015 to June 30, 2016 Issuance of stock in initial public offering, net of $2,025 in offering costs Issuance of common stock to financial advisor, noncash Conversion of preferred stock Conversion of notes payable and related accrued interest Conversion of bridge loan and related accrued interest Cashless exercise of warrants Exercise of options On May 17, 2016, following the effectiveness of the conversion price amendment, we effected a reverse stock split at a ratio of 1-for-10.656096 of our issued and outstanding shares of common stock.

1.The conversion of $12.6 million of convertible notes and related accrued interest into Series A preferred stock and then into 1,843,369 shares of common stock in accordance with the terms of such notes and, with respect to Series A preferred stock. 2.The conversion of $3.6 million of convertible notes and related accrued interest into 945,511 shares of common stock in accordance with the terms of such notes; 3.The conversion of $4.0 million principal amount of term loans together with all accrued and unpaid interest thereon into 1,021,525 shares of common stock at a conversion price equal to 80% of the initial public offering price in this offering in accordance with the terms of such notes; 4.The conversion of 25,716,583 outstanding shares of preferred stock into 3,229,975 shares of common stock under the terms of third amended and restated certificate of incorporation, as amended; 5.The exercise of warrants to purchase 2,452,242 shares of preferred stock at an exercise price of $0.01 per share and the conversion of the preferred stock issuable upon exercise of such warrants into 308,001 shares of common stock under the terms of third amended and restated certificate of incorporation, as amended; and following each of the foregoing, the 1-for-10.656096 reverse stock split of outstanding shares of common stock. 6.Sale of 3,700,000 shares of common stock in this offering, at the initial public offering price of $5.00 per share after deducting underwriting discounts and commissions and estimated offering expenses payable by us; and the accounting of the value of an aggregate of 1,393,880 shares of common stock certain of existing investors that collectively beneficially own the majority of common stock will transfer to Titan Multi-Strategy Fund I, LTD. and certain of its third-party designees at a nominal purchase price, which constitutes an expense for us, as the primary benefactor. The expense was calculated based on the initial public offering price of $5.00 per share.

from December 31, 2014 to December 31, 2015 Exercise of stock options Exercise of common stock warrants