RARX

-- -- --

from December 31, 2018 to December 31, 2019 Issuance of common stock from public offerings, net of underwriter discounts and issuance costs Exercise of common stock options

from June 30, 2019 to September 30, 2019 Issuance of common stock from public offerings, net of underwriter discounts and issuance costs Exercise of common stock options

from March 31, 2019 to June 30, 2019 Exercise of common stock options Shares issued under stock option and employee purchase plans, net of tax withholdings

from December 31, 2018 to March 31, 2019 Exercise of common stock options Shares issued under stock option and employee purchase plans, net of tax withholdings

from December 31, 2017 to December 31, 2018 Issuance of common stock from public offerings, net of underwriter discounts and issuance costs Exercise of common stock options

from December 31, 2016 to December 31, 2017 Exercise of common stock options

from December 31, 2015 to December 31, 2016 Conversion of redeemable convertible preferred stock into common stock Sale of Series B-2 Convertible Preferred Stock at $0.99617 per share, net of issuance costs of $22 Exercise of common stock options Exercise of warrants Issuance of Common Stock from Initial Public Offering, net of underwriters discounts and issuance costs On October 14, 2016, the Company effected a one-for-seven reverse stock split of the Company's Common Stock.

2,095,494 shares of common stock issuable upon the exercise of stock options outstanding as of September 30, 2016 under our 2010 Stock Option and Grant Plan, or the 2010 Plan, at a weighted average exercise price of $3.96 per share; An additional 101,109 shares of common stock available for future issuance under our 2010 Plan as of September 30, 2016; An additional 1,300,000 shares of common stock that were made available for future issuance under our 2016 Stock Award and Incentive Plan upon the effectiveness of the registration statement of which this prospectus forms a part, 72,856 of which were issued in connection with this offering; An additional 175,000 shares of common stock made available for future issuance under our 2016 Employee Stock Purchase Plan upon the effectiveness of the registration statement of which this prospectus forms a part.

The Company's Board of Directors and stockholders approved a one-for-7 reverse stock split of the Company's common stock that became effective on October 14, 2016. All share and per share amounts in the consolidated financial statements and notes thereto have been retroactively adjusted for all periods presented to give effect to this reverse stock split.

The Company effected a one-for-seven reverse stock split of the Company’s common stock. The reverse stock split became effective on October 14, 2016. The par value and authorized shares of common stock and convertible preferred stock were not adjusted as a result of the reverse stock split.

from December 31, 2015 to June 30, 2016 Sale of Series B-2 Convertible Preferred Stock at $0.99617 per share, net of issuance costs of $21 (unaudited) Exercise of common stock options (unaudited)