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股本结构

单位：万股
公告日期 2023-06-15 2023-06-15 2023-05-11 2023-05-11 2023-03-31 2023-03-31
证券总股本 20524.57 20525.20 20526.15 20528.45 20530.14 20282.78
普通股本 20524.57 20525.20 20526.15 20528.45 20530.14 20282.78
优先股 未披露 未披露 未披露 未披露 未披露 未披露
其他 未披露 未披露 未披露 未披露 未披露 未披露
变动日期 2023-06-13 2023-05-26 2023-05-09 2023-03-31 2023-03-22 2022-12-31
注释：中概股证券总股本=普通股股本/ 存托凭证比例

历史变动

公告日期 变动后普通股本（万股） 变动后优先股（万股） 变动原因 变动日期
2023-06-15 20524.57 未披露 定期报告 2023-06-13
2023-06-15 20525.20 未披露 定期报告 2023-05-26
2023-05-11 20526.15 未披露 定期报告 2023-05-09
2023-05-11 20528.45 未披露
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From December 31, 2022 to March 31, 2023 Restricted stock award grants, net of forfeitures Issuance of common stock upon vesting of restricted stock units Issuance of common shares under at-the-market sales agreement Issuance of common stock upon exercise of stock options
2023-03-31
2023-03-31 20530.14 未披露 定期报告 2023-03-22
2023-03-31 20282.78 未披露
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From December 31, 2021 to December 31, 2022 Restricted stock award grants, net of forfeitures Issuance of common shares to Hanmi Pharmaceutical Co., Ltd. Issuance of common stock for employee stock purchase plan Issuance of common stock upon vesting of performance units Issuance of common stock upon vesting of restricted stock units Issuance of common shares pursuant to at-the-market offering, net
2022-12-31
2022-11-14 20320.55 未披露 定期报告 2022-11-07
2022-11-14 20333.97 未披露
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From June 30, 2022 to September 30, 2022 Issuance of common shares pursuant to at-the-market offering, net Restricted stock award grants, net of forfeitures
2022-09-30
2022-08-12 18816.42 未披露 定期报告 2022-08-08
2022-08-12 18487.03 未披露
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From March 31, 2022 to June 30, 2022 Issuance of common shares pursuant to at-the-market offering, net of offering costs Issuance of common stock for employee stock purchase plan Restricted stock award grants, net of forfeitures
2022-06-30
2022-05-12 18008.72 未披露 定期报告 2022-05-09
2022-04-27 17925.75 未披露 定期报告 2022-04-23
2022-04-27 17915.75 未披露 定期报告 2022-04-08
2022-05-12 17882.75 未披露
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From December 31, 2021 to March 31, 2022 Restricted stock award grants, net of forfeitures Issuance of common shares to Hanmi Pharmaceutical Co., Ltd. Issuance of common stock upon vesting of performance units
2022-03-31
2022-03-18 17715.15 未披露 定期报告 2022-03-10
2022-03-18 16450.20 未披露
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From December 31, 2020 to December 31, 2021 Issuance of common shares under an at-the-market sales agreement Issuance of common stock for employee stock purchase plan Issuance of common stock upon exercise of stock options Restricted stock award grants, net of forfeitures Issuance of common stock upon vesting of restricted stock units
2021-12-31
2021-11-10 16395.63 未披露 定期报告 2021-11-08
2021-11-10 16395.79 未披露
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From June 30, 2021 to September 30, 2021 Restricted stock award grants, net of forfeitures
2021-09-30
2021-08-12 16407.19 未披露 定期报告 2021-08-06
2021-08-12 16410.61 未披露
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From March 31, 2021 to June 30, 2021 Issuance of common shares under an at-the-market sales agreement Issuance of common stock upon exercise of stock options Issuance of common stock for employee stock purchase plan Restricted stock award grants, net of forfeitures Issuance of common stock upon vesting of restricted stock units
2021-06-30
2021-05-13 16152.06 未披露 定期报告 2021-05-10
2021-04-21 15571.32 未披露 定期报告 2021-04-20
2021-04-21 15499.43 未披露 定期报告 2021-04-14
2021-05-13 15372.83 未披露
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From December 31, 2020 To March 31, 2021 Issuance of common shares under an at-the-market sales agreement Restricted stock award grants, net of forfeitures
2021-03-31
2021-03-31 15372.83 未披露 定期报告 2021-03-24
2021-03-31 14608.31 未披露
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from December 31, 2019 to December 31, 2020 Issuance of common stock from public offering Issuance of common shares under an at-the-market sales agreement Issuance of common stock to 401(k) plan for employees Issuance of common stock for employee stock purchase plan Issuance of common stock upon exercise of stock options Restricted stock award grants, net of forfeitures Issuance of common stock upon vesting of restricted stock units
2020-12-31
2020-11-04 14592.22 未披露 定期报告 2020-10-31
2020-11-04 14593.12 未披露
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From June 30, 2020 to September 30, 2020 Issuance of common stock from public offering,net Issuance of common shares pursuant to at-the-market offering,net Issuance of common stock upon exercise of stock options Restricted stock award grants,net of forfeitures
2020-09-30
2020-08-10 14573.36 未披露 定期报告 2020-08-05
2020-08-03 13644.07 未披露
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1.Common stock offered by the company 21,666,667 shares. 2.The number of shares of common stock to be outstanding immediately after the closing of this offering is based on 114,774,079 shares of common stock outstanding as of March 31, 2020.
2020-08-03
2020-08-10 11782.40 未披露
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from March 31, 2020 to June 30, 2020 Issuance of common stock for employee stock purchase plan Restricted stock award grants, net of forfeitures Issuance of common stock upon vesting of restricted stock units Issuance of common shares under an at-the-market sales agreement
2020-06-30
2020-05-07 11646.85 未披露 定期报告 2020-05-04
2020-05-07 11646.85 未披露 定期报告 2020-04-30
2020-04-22 11646.60 未披露 定期报告 2020-04-17
2020-05-07 11477.41 未披露
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from December 31, 2019 to March 31, 2020 Issuance of common stock to 401(k) plan for employees Restricted stock award grants, net of forfeitures
2020-03-31
2020-03-20 11479.90 未披露 定期报告 2020-03-16
2020-03-02 11368.99 未披露 定期报告 2020-02-21
2020-03-02 11329.96 未披露
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from December 31, 2018 to December 31, 2019 Issuance of common stock to 401(k) plan for employees Issuance of common stock for employee stock purchase plan Issuance of common stock upon exercise of stock options Restricted stock award grants, net of forfeitures Issuance of common stock upon vesting of restricted stock units Issuance of common shares under an at-the-market sales agreement
2019-12-31
2019-11-07 11297.33 未披露 定期报告 2019-10-31
2019-11-07 11298.87 未披露
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from June 30, 2019 to September 30, 2019 Issuance of common stock to 401(k) plan for employees Issuance of common stock upon exercise of stock options Restricted stock award grants, net of forfeitures
2019-09-30
2019-08-09 11285.57 未披露 定期报告 2019-07-31
2019-08-09 11268.44 未披露
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From March 31, 2019 to June 30, 2019 Issuance of common stock to 401(k) plan for employee match Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options RSA grants, net of forfeitures Issuance of common stock upon vesting of RSUs Issuance of common shares under an at-the-market sales agreement
2019-06-30
2019-05-09 11196.35 未披露 定期报告 2019-04-30
2019-04-23 11195.10 未披露 定期报告 2019-04-22
2019-04-23 11183.56 未披露 定期报告 2019-04-01
2019-05-09 11121.26 未披露
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from December 31, 2018 to March 31, 2019 Issuance of common stock to 401(k) plan for employee match Issuance of common stock upon exercise of stock options RSA grants, net of forfeitures Issuance of common stock upon vesting of RSUs
2019-03-31
2019-02-28 11105.00 未披露 定期报告 2019-02-21
2019-02-28 11052.51 未披露
更多>>
from December 31, 2017 to December 31, 2018 Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options RSA and stock option issuances and forfeitures for terminations, net Issuance of common stock upon vesting of RSUs Issuance of common stock upon exercise of warrants Repurchase/retirement of RSAs and option exercises to satisfy employee tax withholdings and exercise price Common stock redeemed on 2018 Convertible Notes
2018-12-31
2018-11-08 10691.34 未披露 定期报告 2018-10-31
2018-11-08 10606.07 未披露 定期报告 2018-09-30
2018-08-09 10595.88 未披露 定期报告 2018-07-31
2018-08-09 10513.06 未披露 定期报告 2018-06-30
2018-05-04 10405.51 未披露 定期报告 2018-04-30
2018-05-07 10407.57 未披露 定期报告 2018-04-20
2018-05-04 10393.54 未披露 定期报告 2018-03-31
2018-03-07 10271.46 未披露 定期报告 2018-02-15
2018-03-07 10074.27 未披露
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from December 31, 2016 to December 31, 2017 Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options, net RSA and stock option issuances and forfeitures for terminations, net Repurchase/retirement of RSAs to satisfy employee tax withholding Common stock issued under an at-market-issuance sales agreement Conversion hedge unwind in connection with open market purchases of 2018 Convertible Notes
2017-12-31
2017-11-03 10066.22 未披露 定期报告 2017-10-31
2017-11-03 9406.17 未披露 定期报告 2017-09-30
2017-08-04 8450.22 未披露 定期报告 2017-07-28
2017-08-03 8125.72 未披露 定期报告 2017-06-30
2017-05-04 8041.23 未披露 定期报告 2017-04-24
2017-04-17 8044.39 未披露 定期报告 2017-04-17
2017-05-04 8042.38 未披露 定期报告 2017-03-31
2017-03-14 8046.67 未披露
更多>>
from December 31, 2015 to December 31, 2016 Conversion of preferred shares into common stock Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options RSA issuances and forfeitures for terminations, net Purchase/retirement of RSAs to satisfy employee tax withholding Common stock issued under an at-market-issuance sales agreement Issuance of common stock for ROLONTIS milestone achievement Issuance of common stock for QAPZOLA milestone achievement
2016-12-31
2016-11-14 8055.79 未披露 定期报告 2016-10-31
2016-11-14 8056.67 未披露 定期报告 2016-09-30
2016-08-09 8021.67 未披露 定期报告 2016-07-28
2016-08-09 7590.27 未披露 定期报告 2016-06-30
2016-05-06 6922.06 未披露 定期报告 2016-04-29
2016-05-06 6894.20 0.0020 定期报告 2016-03-31
2016-01-25 6817.29 0.0020 定期报告 2016-01-15
2016-03-14 6822.89 0.0020
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From December 31, 2014 to December 31, 2015 Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options Share-based compensation expense and common stock issued (net of forfeitures) Repurchase of shares to satisfy employee tax withholding
2015-12-31
2015-11-06 6733.99 未披露 定期报告 2015-10-31
2015-11-04 6731.46 0.0020 定期报告 2015-09-30
2015-08-07 6731.14 未披露 定期报告 2015-07-31
2015-08-07 6724.56 0.0020 定期报告 2015-06-30
2015-04-30 6699.51 0.0020 定期报告 2015-04-30
2015-05-07 6690.58 0.0020 定期报告 2015-03-31
2015-03-13 6687.12 未披露 定期报告 2015-02-28
2015-03-13 6596.97 0.0020
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from December 31, 2013 to December 31, 2014 Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options Share-based compensation expense and common stock issued (net of forfeitures) Repurchase of shares to satisfy employee tax withholding Issuance of common stock to TopoTarget for milestone achievement
2014-12-31
2014-11-10 6576.05 未披露 定期报告 2014-10-31
2014-11-06 6574.32 0.0020 定期报告 2014-09-30
2014-08-08 6573.20 未披露 定期报告 2014-07-31
2014-08-07 6573.09 0.0020 定期报告 2014-06-30
2014-05-12 6558.22 未披露 定期报告 2014-04-28
2014-05-08 6564.96 0.0020 定期报告 2014-03-31
2014-03-26 6529.66 未披露 定期报告 2014-03-21
2014-03-12 6528.78 未披露 定期报告 2014-02-28
2014-03-12 6410.42 0.0020
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from December 31, 2012 to December 31, 2013 Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options Share-based compensation expense and common stock issued (net of forfeitures) Repurchase of shares to satisfy employee tax withholding Retirement of treasury stock Issuance of common stock for Talon acquisition
2013-12-31
2013-11-18 6387.97 未披露 定期报告 2013-11-14
2013-11-12 6382.51 0.0020 定期报告 2013-09-30
2013-08-09 6330.77 未披露 定期报告 2013-08-05
2013-08-09 6028.46 0.0020 定期报告 2013-06-30
2013-04-30 6002.68 未披露 定期报告 2013-04-29
2013-05-09 6000.78 0.0020 定期报告 2013-03-31
2013-02-28 6015.70 未披露 定期报告 2013-02-15
2013-02-28 6002.67 0.0020
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from December 31, 2011 to December 31, 2012 Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options Issuance of common stock upon exercise of warrant Share-based compensation expense and common stock issued (net of forfeitures) Repurchase of shares to satisfy tax withholding Retirement of treasury stock
2012-12-31
2012-11-21 5965.00 0.0020 定期报告 2012-11-21
2012-11-09 5954.33 未披露 定期报告 2012-10-26
2012-11-09 5952.53 0.0020 定期报告 2012-09-30
2012-08-08 6024.38 未披露 定期报告 2012-07-18
2012-08-08 5982.45 0.0020 定期报告 2012-06-30
2012-04-27 5952.24 未披露 定期报告 2012-04-20
2012-04-27 5945.94 0.0020 定期报告 2012-03-31
2012-03-02 5927.10 未披露 定期报告 2012-02-16
2012-03-02 5924.75 0.0020
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from December 31, 2010 to December 31, 2011 Conversion of Series E preferred stock to common stock Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options Issuance of common stock upon exercise of warrants Share-based compensation expense and common stock issued (net of forfeitures) Issuance of restricted stock for management incentive plan, net of shares repurchased/retired for minimum tax withholding Fair value of common stock issued to Targent for milestone
2011-12-31
2011-10-28 5740.74 未披露 定期报告 2011-10-19
2011-10-28 5740.37 0.0020 定期报告 2011-09-30
2011-08-04 5319.79 未披露 定期报告 2011-07-29
2011-08-04 5294.72 0.0020 定期报告 2011-06-30
2011-05-04 5204.18 未披露 定期报告 2011-04-22
2011-05-04 5202.18 0.0026 定期报告 2011-03-31
2011-03-10 5200.35 未披露 定期报告 2011-02-25
2011-03-10 5145.93 0.0026
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from dec 31 2009 to dec 31 2010 Conversion of Series E preferred stock to common stock Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options Share-based compensation expense and common stock issued (net of forfeitures) Fair value of common stock issued in connection with drug license
2010-12-31
2010-11-04 5048.77 未披露 定期报告 2010-10-22
2010-11-04 5037.03 0.0068 定期报告 2010-09-30
2010-08-09 5014.11 未披露 定期报告 2010-08-02
2010-08-09 4966.27 0.0068 定期报告 2010-06-30
2010-05-10 4949.78 未披露 定期报告 2010-05-03
2010-05-10 4918.71 0.0068 定期报告 2010-03-31
2010-04-05 4917.10 未披露 定期报告 2010-03-29
2010-04-05 4892.63 0.0068
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from December 31, 2008 to December 31, 2009 Issuance of common stock and warrants for cash, net of issuance costs Issuance of common stock to employees - shelf takedown Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options Share-based compensation expense and common stock issued (net of forfeitures) Fair value of common stock issued to Targent, Inc. for NDA Approval Fair value of common stock issued to Altair Inc. for Renazorb rights
2009-12-31
2009-03-31 3253.06 未披露 定期报告 2009-03-27
2009-03-31 3216.63 0.0068
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from December 31, 2007 to December 31, 2008 Conversion of Series E Preferred Stock into Common Stock Fair value of common stock issued to Targent, Inc. for NDA Approval Fair value of common stock issued to NDDO, University of Bradford Share-based compensation expense and common stock issued Issuance of common stock to 401(k) plan
2008-12-31
2008-03-14 3123.38 0.02
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from December 31, 2006 to December 31, 2007 Conversion of Series D preferred stock into common stock Issuance of common stock and warrants for cash, net of issuance costs Fair value of common stock issued to Targent, Inc. for milestones Share-based compensation expense and common stock issued Issuance of common stock upon exercise of warrants Issuance of common stock upon exercise of employee stock options Issuance of common stock to 401(k) plan Fair value of common stock issued to consultant for services Fractional share adjustments Series D preferred stock dividend paid with common stock
2007-12-31
2007-03-14 2532.57 未披露 定期报告 2007-03-09
2007-03-14 2521.78 0.02
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from December 31, 2005 to December 31, 2006 Conversion of Series D Preferred Stock into common stock Conversion of Series E Preferred Stock into common stock Issuance of common stock and warrants to JBCPL for cash Fair value of common stock issued to Tangent, Inc. for acquisition of assets Fair value of common stock issued to Altair Nanotechnologies, Inc. for milestones Issuance of common stock upon exercise of warrants Issuance of common stock upon exercise of employee stock options Issuance of common stock to 401(k) plan Fractional share adjustments Share-based compensation expense and common stock issued Series D Preferred Stock dividend paid with common stock
2006-12-31
2006-03-15 2370.93 未披露 定期报告 2006-03-10
2006-03-15 2350.32 0.04
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from December 31, 2004 to December 31, 2005 Issuance of common stock and warrants for cash, net of issuance costs Fair value of common stock issued in connection with drug license Issuance of common stock upon exercise of warrants Issuance of common stock upon exercise of employee stock options Issuance of common stock to employees as compensation Series D Preferred Stock dividend paid with common stock
2005-12-31
2005-03-15 1532.65 未披露 定期报告 2005-03-01
2005-03-15 1482.56 0.04
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from December 31, 2003 to December 31, 2004 Conversion of Series D Preferred Stock into common stock Conversion of Series E Preferred Stock into common stock Issuance of common stock for cash, net of issuance costs Fair value of common stock issued in connection with drug license Issuance of common stock upon exercise of warrants Issuance of common stock upon exercise of employee stock options Series D Preferred Stock dividends paid with common stock
2004-12-31
2004-03-29 1000.37 未披露 定期报告 2004-03-19
2004-03-29 809.79 0.16
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from December 31, 2002 to December 31, 2003 Issuance of Series D Preferred Stock and common stock warrants, net Issuance of Series E Preferred Stock and common stock warrants, net Conversion of Series D Preferred Stock into common stock Conversion of Series E Preferred Stock into common stock Issuance of common stock and warrants for cash, net of issuance costs Issuance of common stock upon exercise of warrants Issuance of common stock to employees as compensation Issuance of common stock upon exercise of Recognition of beneficial conversion feature on preferred stock Preferred dividends: Deemed dividend related to beneficial conversion features on preferred stock Deemed dividend related to issuance costs Series D Preferred Stock dividend paid with common stock
2003-12-31
2003-03-28 294.82 未披露 定期报告 2003-03-21
2003-03-28 272.60 未披露
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from December 31, 2001 to December 31, 2002 Sale of common stock for cash net of issuance costs Cash payment of fractional shares due to the reverse stock split Fair value of common stock issued to vendors for services rendered Repurchase of common stock
2002-12-31
2002-04-02 2687.70 未披露 定期报告 2002-03-22
2002-04-02 2377.72 未披露
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from December 31, 2000 to December 31, 2001 Comprehensive loss Sale of common stock for cash net of issuance costs Fair value of common stock issued for consulting services Conversion of Preferred Stock of Subsidiary into Series C Preferred Stock Conversion of Series C Preferred Stock into common stock Purchase and retirement of Series C Preferred Stock
2001-12-31
2001-04-17 1725.53 未披露 定期报告 2001-03-30
2001-04-17 1330.72 未披露
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from December 31, 1999 to December 31, 2000 Sale of common stock to Private Equity Line investor, net of costs of issuance Sale of common stock and warrants sold with 5% convertible debentures Common stock issued to consultants for services Public warrant exercise Stock options exercised by employees Stock options exercised by consultants
2000-12-31
2000-04-13 953.41 未披露 定期报告 2000-03-22
2000-04-13 877.84 未披露
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from December 31, 1998 to December 31, 1999 Sale of common stock to Private Equity Line investor, net of costs of issuance Sale of shares of 5% Series A Preferred Stock, net of offering costs and allocated warrants Conversion of preferred stock into common stock Common stock and warrants issued for cash under an exempt private sale agreement, net of offering costs Sale of common stock pursuant to a secondary public offering, net of offering costs Common stock issued to legal counsel for services Exercise of underwriters' warrant Stock options exercised by employees Sale of common stock to private investors Common stock forfeiture in settlement of litigation Common stock and warrants issued in settlement of litigation Fractional share adjustment upon conversion of pre-split shares
1999-12-31
1999-03-31 622.57 未披露 定期报告 1999-03-16
1999-03-31 614.69 未披露
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from December 31, 1997 to December 31, 1998 Common stock and warrants issued for cash under Line of Equity Agreement, net of issue costs Stock options exercised by employees, directors, and consultants Exercise of underwriters' warrants Fractional shares adjustment upon conversion of pre-split shares
1998-12-31
1998-03-31 547.43 未披露 定期报告 1998-03-16
1998-03-31 546.58 未披露
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from December 31, 1996 to December 31, 1997 Stock options exercised
1997-12-31
1997-03-31 536.18 未披露
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from December 31, 1995 to December 31, 1996 Common stock issued for cash at $2.50 (net of commission) Cash paid out for fractional shares Conversion of Revenue Participation units into common stock Common stock and warrants issued for cash at $7.60, less commissions and costs of public offering In June 1996, the Board of Directors authorized, with shareholder approval, a reverse split of the Company's outstanding Common Stock on the basis of 1 share for each 2.5 shares of the then outstanding Common Stock.
1996-12-31
From December 31, 2022 to March 31, 2023 Restricted stock award grants, net of forfeitures Issuance of common stock upon vesting of restricted stock units Issuance of common shares under at-the-market sales agreement Issuance of common stock upon exercise of stock options
From December 31, 2021 to December 31, 2022 Restricted stock award grants, net of forfeitures Issuance of common shares to Hanmi Pharmaceutical Co., Ltd. Issuance of common stock for employee stock purchase plan Issuance of common stock upon vesting of performance units Issuance of common stock upon vesting of restricted stock units Issuance of common shares pursuant to at-the-market offering, net
From June 30, 2022 to September 30, 2022 Issuance of common shares pursuant to at-the-market offering, net Restricted stock award grants, net of forfeitures
From March 31, 2022 to June 30, 2022 Issuance of common shares pursuant to at-the-market offering, net of offering costs Issuance of common stock for employee stock purchase plan Restricted stock award grants, net of forfeitures
From December 31, 2021 to March 31, 2022 Restricted stock award grants, net of forfeitures Issuance of common shares to Hanmi Pharmaceutical Co., Ltd. Issuance of common stock upon vesting of performance units
From December 31, 2020 to December 31, 2021 Issuance of common shares under an at-the-market sales agreement Issuance of common stock for employee stock purchase plan Issuance of common stock upon exercise of stock options Restricted stock award grants, net of forfeitures Issuance of common stock upon vesting of restricted stock units
From June 30, 2021 to September 30, 2021 Restricted stock award grants, net of forfeitures
From March 31, 2021 to June 30, 2021 Issuance of common shares under an at-the-market sales agreement Issuance of common stock upon exercise of stock options Issuance of common stock for employee stock purchase plan Restricted stock award grants, net of forfeitures Issuance of common stock upon vesting of restricted stock units
From December 31, 2020 To March 31, 2021 Issuance of common shares under an at-the-market sales agreement Restricted stock award grants, net of forfeitures
from December 31, 2019 to December 31, 2020 Issuance of common stock from public offering Issuance of common shares under an at-the-market sales agreement Issuance of common stock to 401(k) plan for employees Issuance of common stock for employee stock purchase plan Issuance of common stock upon exercise of stock options Restricted stock award grants, net of forfeitures Issuance of common stock upon vesting of restricted stock units
From June 30, 2020 to September 30, 2020 Issuance of common stock from public offering,net Issuance of common shares pursuant to at-the-market offering,net Issuance of common stock upon exercise of stock options Restricted stock award grants,net of forfeitures
1.Common stock offered by the company 21,666,667 shares. 2.The number of shares of common stock to be outstanding immediately after the closing of this offering is based on 114,774,079 shares of common stock outstanding as of March 31, 2020.
from March 31, 2020 to June 30, 2020 Issuance of common stock for employee stock purchase plan Restricted stock award grants, net of forfeitures Issuance of common stock upon vesting of restricted stock units Issuance of common shares under an at-the-market sales agreement
from December 31, 2019 to March 31, 2020 Issuance of common stock to 401(k) plan for employees Restricted stock award grants, net of forfeitures
from December 31, 2018 to December 31, 2019 Issuance of common stock to 401(k) plan for employees Issuance of common stock for employee stock purchase plan Issuance of common stock upon exercise of stock options Restricted stock award grants, net of forfeitures Issuance of common stock upon vesting of restricted stock units Issuance of common shares under an at-the-market sales agreement
from June 30, 2019 to September 30, 2019 Issuance of common stock to 401(k) plan for employees Issuance of common stock upon exercise of stock options Restricted stock award grants, net of forfeitures
From March 31, 2019 to June 30, 2019 Issuance of common stock to 401(k) plan for employee match Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options RSA grants, net of forfeitures Issuance of common stock upon vesting of RSUs Issuance of common shares under an at-the-market sales agreement
from December 31, 2018 to March 31, 2019 Issuance of common stock to 401(k) plan for employee match Issuance of common stock upon exercise of stock options RSA grants, net of forfeitures Issuance of common stock upon vesting of RSUs
from December 31, 2017 to December 31, 2018 Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options RSA and stock option issuances and forfeitures for terminations, net Issuance of common stock upon vesting of RSUs Issuance of common stock upon exercise of warrants Repurchase/retirement of RSAs and option exercises to satisfy employee tax withholdings and exercise price Common stock redeemed on 2018 Convertible Notes
from December 31, 2016 to December 31, 2017 Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options, net RSA and stock option issuances and forfeitures for terminations, net Repurchase/retirement of RSAs to satisfy employee tax withholding Common stock issued under an at-market-issuance sales agreement Conversion hedge unwind in connection with open market purchases of 2018 Convertible Notes
from December 31, 2015 to December 31, 2016 Conversion of preferred shares into common stock Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options RSA issuances and forfeitures for terminations, net Purchase/retirement of RSAs to satisfy employee tax withholding Common stock issued under an at-market-issuance sales agreement Issuance of common stock for ROLONTIS milestone achievement Issuance of common stock for QAPZOLA milestone achievement
From December 31, 2014 to December 31, 2015 Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options Share-based compensation expense and common stock issued (net of forfeitures) Repurchase of shares to satisfy employee tax withholding
from December 31, 2013 to December 31, 2014 Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options Share-based compensation expense and common stock issued (net of forfeitures) Repurchase of shares to satisfy employee tax withholding Issuance of common stock to TopoTarget for milestone achievement
from December 31, 2012 to December 31, 2013 Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options Share-based compensation expense and common stock issued (net of forfeitures) Repurchase of shares to satisfy employee tax withholding Retirement of treasury stock Issuance of common stock for Talon acquisition
from December 31, 2011 to December 31, 2012 Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options Issuance of common stock upon exercise of warrant Share-based compensation expense and common stock issued (net of forfeitures) Repurchase of shares to satisfy tax withholding Retirement of treasury stock
from December 31, 2010 to December 31, 2011 Conversion of Series E preferred stock to common stock Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options Issuance of common stock upon exercise of warrants Share-based compensation expense and common stock issued (net of forfeitures) Issuance of restricted stock for management incentive plan, net of shares repurchased/retired for minimum tax withholding Fair value of common stock issued to Targent for milestone
from dec 31 2009 to dec 31 2010 Conversion of Series E preferred stock to common stock Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options Share-based compensation expense and common stock issued (net of forfeitures) Fair value of common stock issued in connection with drug license
from December 31, 2008 to December 31, 2009 Issuance of common stock and warrants for cash, net of issuance costs Issuance of common stock to employees - shelf takedown Issuance of common stock to 401(k) plan Issuance of common stock for ESPP Issuance of common stock upon exercise of stock options Share-based compensation expense and common stock issued (net of forfeitures) Fair value of common stock issued to Targent, Inc. for NDA Approval Fair value of common stock issued to Altair Inc. for Renazorb rights
from December 31, 2007 to December 31, 2008 Conversion of Series E Preferred Stock into Common Stock Fair value of common stock issued to Targent, Inc. for NDA Approval Fair value of common stock issued to NDDO, University of Bradford Share-based compensation expense and common stock issued Issuance of common stock to 401(k) plan
from December 31, 2006 to December 31, 2007 Conversion of Series D preferred stock into common stock Issuance of common stock and warrants for cash, net of issuance costs Fair value of common stock issued to Targent, Inc. for milestones Share-based compensation expense and common stock issued Issuance of common stock upon exercise of warrants Issuance of common stock upon exercise of employee stock options Issuance of common stock to 401(k) plan Fair value of common stock issued to consultant for services Fractional share adjustments Series D preferred stock dividend paid with common stock
from December 31, 2005 to December 31, 2006 Conversion of Series D Preferred Stock into common stock Conversion of Series E Preferred Stock into common stock Issuance of common stock and warrants to JBCPL for cash Fair value of common stock issued to Tangent, Inc. for acquisition of assets Fair value of common stock issued to Altair Nanotechnologies, Inc. for milestones Issuance of common stock upon exercise of warrants Issuance of common stock upon exercise of employee stock options Issuance of common stock to 401(k) plan Fractional share adjustments Share-based compensation expense and common stock issued Series D Preferred Stock dividend paid with common stock
from December 31, 2004 to December 31, 2005 Issuance of common stock and warrants for cash, net of issuance costs Fair value of common stock issued in connection with drug license Issuance of common stock upon exercise of warrants Issuance of common stock upon exercise of employee stock options Issuance of common stock to employees as compensation Series D Preferred Stock dividend paid with common stock
from December 31, 2003 to December 31, 2004 Conversion of Series D Preferred Stock into common stock Conversion of Series E Preferred Stock into common stock Issuance of common stock for cash, net of issuance costs Fair value of common stock issued in connection with drug license Issuance of common stock upon exercise of warrants Issuance of common stock upon exercise of employee stock options Series D Preferred Stock dividends paid with common stock
from December 31, 2002 to December 31, 2003 Issuance of Series D Preferred Stock and common stock warrants, net Issuance of Series E Preferred Stock and common stock warrants, net Conversion of Series D Preferred Stock into common stock Conversion of Series E Preferred Stock into common stock Issuance of common stock and warrants for cash, net of issuance costs Issuance of common stock upon exercise of warrants Issuance of common stock to employees as compensation Issuance of common stock upon exercise of Recognition of beneficial conversion feature on preferred stock Preferred dividends: Deemed dividend related to beneficial conversion features on preferred stock Deemed dividend related to issuance costs Series D Preferred Stock dividend paid with common stock
from December 31, 2001 to December 31, 2002 Sale of common stock for cash net of issuance costs Cash payment of fractional shares due to the reverse stock split Fair value of common stock issued to vendors for services rendered Repurchase of common stock
from December 31, 2000 to December 31, 2001 Comprehensive loss Sale of common stock for cash net of issuance costs Fair value of common stock issued for consulting services Conversion of Preferred Stock of Subsidiary into Series C Preferred Stock Conversion of Series C Preferred Stock into common stock Purchase and retirement of Series C Preferred Stock
from December 31, 1999 to December 31, 2000 Sale of common stock to Private Equity Line investor, net of costs of issuance Sale of common stock and warrants sold with 5% convertible debentures Common stock issued to consultants for services Public warrant exercise Stock options exercised by employees Stock options exercised by consultants
from December 31, 1998 to December 31, 1999 Sale of common stock to Private Equity Line investor, net of costs of issuance Sale of shares of 5% Series A Preferred Stock, net of offering costs and allocated warrants Conversion of preferred stock into common stock Common stock and warrants issued for cash under an exempt private sale agreement, net of offering costs Sale of common stock pursuant to a secondary public offering, net of offering costs Common stock issued to legal counsel for services Exercise of underwriters' warrant Stock options exercised by employees Sale of common stock to private investors Common stock forfeiture in settlement of litigation Common stock and warrants issued in settlement of litigation Fractional share adjustment upon conversion of pre-split shares
from December 31, 1997 to December 31, 1998 Common stock and warrants issued for cash under Line of Equity Agreement, net of issue costs Stock options exercised by employees, directors, and consultants Exercise of underwriters' warrants Fractional shares adjustment upon conversion of pre-split shares
from December 31, 1996 to December 31, 1997 Stock options exercised
from December 31, 1995 to December 31, 1996 Common stock issued for cash at $2.50 (net of commission) Cash paid out for fractional shares Conversion of Revenue Participation units into common stock Common stock and warrants issued for cash at $7.60, less commissions and costs of public offering In June 1996, the Board of Directors authorized, with shareholder approval, a reverse split of the Company's outstanding Common Stock on the basis of 1 share for each 2.5 shares of the then outstanding Common Stock.