股本结构
单位：万股
| 公告日期 | 2026-08-05 | 2026-08-05 | 2026-05-06 | 2026-04-23 | 2026-05-06 | 2026-04-23 |
|---|---|---|---|---|---|---|
| 证券总股本 | 25553.51 | 25526.50 | 25416.27 | 25410.59 | 25401.40 | 21305.96 |
| 普通股本 | 25553.51 | 25526.50 | 25416.27 | 25410.59 | 25401.40 | 21305.96 |
| 优先股 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2026-07-31 | 2026-06-30 | 2026-04-30 | 2026-04-13 | 2026-03-31 | 2025-12-31 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2026-08-05 | 25553.51 | 未披露 | 定期报告 | 2026-07-31 |
| 2026-08-05 | 25526.50 | 未披露 |
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From March 31,2026 to June 30,2026
Exercise of stock options
Issuance of shares to directors in lieu of cash retainer
Shares withheld for taxes for vesting of restricted stock units
Vesting of restricted stock units
|
2026-06-30 |
| 2026-05-06 | 25416.27 | 未披露 | 定期报告 | 2026-04-30 |
| 2026-04-23 | 25410.59 | 未披露 | 定期报告 | 2026-04-13 |
| 2026-05-06 | 25401.40 | 未披露 |
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From December 31, 2025 to March 31, 2026
Exercise of stock options
Vesting of restricted stock units
Employee stock purchase plan sales
Issuance of shares to directors in lieu of cash retainer
Issuance of common stock for the acquisition of Astria Therapeutics, Inc.
|
2026-03-31 |
| 2026-02-26 | 25080.06 | 未披露 | 定期报告 | 2026-02-20 |
| 2026-01-23 | 24803.91 | 未披露 |
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Common Stock offered 37,300,000 shares by the company
|
2026-01-23 |
| 2026-04-23 | 21305.96 | 未披露 |
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From December 31, 2024 to December 31, 2025
Exercise of stock options, net
Vesting of restricted stock units
Shares withheld for taxes for vesting of restricted stock units
Employee stock purchase plan sales
Issuance of shares to directors in lieu of cash retainer
|
2025-12-31 |
| 2025-12-15 | 21073.91 | 未披露 | 定期报告 | 2025-12-09 |
| 2025-11-04 | 21054.32 | 未披露 | 定期报告 | 2025-10-31 |
| 2025-10-14 | 21052.96 | 未披露 | 定期报告 | 2025-10-10 |
| 2025-11-04 | 21052.20 | 未披露 |
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From June 30, 2025 to September 30, 2025
Exercise of stock options, net
Vesting of restricted stock units
Employee stock purchase plan sales
Issuance of shares to directors in lieu of cash retainer
|
2025-09-30 |
| 2025-08-05 | 20992.04 | 未披露 | 定期报告 | 2025-07-31 |
| 2025-08-05 | 20990.50 | 未披露 |
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From March 31, 2025 to June 30, 2025
Exercise of stock options
Vesting of restricted stock units
Issuance of shares to directors in lieu of cash retainer
|
2025-06-30 |
| 2025-05-06 | 20925.03 | 未披露 | 定期报告 | 2025-04-30 |
| 2025-04-24 | 20920.79 | 未披露 | 定期报告 | 2025-04-14 |
| 2025-05-06 | 20920.80 | 未披露 |
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From December 31, 2024 to March 31, 2025
Exercise of stock options
Vesting of restricted stock units
Shares withheld for taxes for vesting of restricted stock units
Employee stock purchase plan sales
Issuance of shares to directors in lieu of cash retainer
|
2025-03-31 |
| 2025-02-25 | 20896.00 | 未披露 | 定期报告 | 2025-02-20 |
| 2025-02-25 | 20854.35 | 未披露 |
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From December 31, 2023 to December 31, 2024
Exercise of stock options
Vesting of restricted stock units
Shares withheld for taxes for vesting of restricted stock units
Employee stock purchase plan sales
Issuance of shares to directors in lieu of cash retainer
|
2024-12-31 |
| 2024-11-05 | 20713.26 | 未披露 | 定期报告 | 2024-10-31 |
| 2024-11-05 | 20711.90 | 未披露 |
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From June 30, 2024 to September 30, 2024
Exercise of stock options
Vesting of restricted stock units
Employee stock purchase plan sales
Issuance of shares to directors in lieu of cash retainer
|
2024-09-30 |
| 2024-08-06 | 20688.59 | 未披露 | 定期报告 | 2024-07-31 |
| 2024-08-06 | 20662.90 | 未披露 |
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From March 31, 2024 to June 30, 2024
Exercise of stock options, net
Vesting of restricted stock units
Issuance of shares to directors in lieu of cash retainer
|
2024-06-30 |
| 2024-05-07 | 20637.71 | 未披露 | 定期报告 | 2024-04-30 |
| 2024-04-25 | 20633.06 | 未披露 | 定期报告 | 2024-04-15 |
| 2024-05-07 | 20634.70 | 未披露 |
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From December 31, 2023 to March 31, 2024
Exercise of stock options, net
Vesting of restricted stock units
Issuance of shares to directors in lieu of cash retainer
Shares withheld for taxes for vesting of restricted stock units
Employee stock purchase plan sales
|
2024-03-31 |
| 2024-02-27 | 20614.99 | 未披露 | 定期报告 | 2024-02-23 |
| 2024-02-27 | 20577.07 | 未披露 |
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From December 31, 2022 to December 31, 2023
Exercise of stock options, 1,276 shares, net
Vesting of restricted stock units, 1,276 shares
Shares withheld for taxes for vesting of restricted stock units, 59 shares
Employee stock purchase plan sales, 338 shares, net
Exercise of warrants, 14,997 shares
|
2023-12-31 |
| 2023-11-08 | 20480.94 | 未披露 | 定期报告 | 2023-10-31 |
| 2023-11-08 | 18980.30 | 未披露 |
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From June 30, 2023 to September 30, 2023
Employee stock purchase plan sales, 162 shares, net
Exercise of stock awards, 149 shares, net
|
2023-09-30 |
| 2023-08-07 | 18949.37 | 未披露 | 定期报告 | 2023-07-28 |
| 2023-08-07 | 18949.10 | 未披露 |
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From March 31, 2023 to June 30, 2023
Exercise of stock options, 608 shares, net
|
2023-06-30 |
| 2023-05-08 | 18893.48 | 未披露 | 定期报告 | 2023-04-28 |
| 2023-04-27 | 18892.08 | 未披露 | 定期报告 | 2023-04-17 |
| 2023-05-08 | 18888.30 | 未披露 |
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From December 31, 2022 to March 31, 2023
Employee stock purchase plan sales, 176 shares, net
Exercise of stock options, 801 shares, net
|
2023-03-31 |
| 2023-02-27 | 18845.11 | 未披露 | 定期报告 | 2023-01-31 |
| 2023-02-27 | 18790.60 | 未披露 |
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From December 31, 2021 to December 31, 2022
Exercise of stock options, 3,044 shares, net
Employee stock purchase plan sales, 260 shares, net
Exercise of warrants, 253 shares
|
2022-12-31 |
| 2022-11-04 | 18642.38 | 未披露 | 定期报告 | 2022-10-31 |
| 2022-11-04 | 18641.10 | 未披露 |
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From June 30, 2022 to September 30, 2022
Employee stock purchase plan sales, 145 shares, net
Exercise of stock options, 390 shares, net
|
2022-09-30 |
| 2022-08-05 | 18594.50 | 未披露 | 定期报告 | 2022-07-29 |
| 2022-08-05 | 18587.60 | 未披露 |
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From March 31, 2022 to June 30, 2022
Exercise of warrants, 253 shares
|
2022-06-30 |
| 2022-05-09 | 18558.39 | 未披露 | 定期报告 | 2022-04-29 |
| 2022-04-25 | 18557.76 | 未披露 | 定期报告 | 2022-04-11 |
| 2022-05-09 | 18557.20 | 未披露 |
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From December 31, 2021 to March 31, 2022
Employee stock purchase plan sales, 115 shares, net
Exercise of stock options, 1,108 shares, net
|
2022-03-31 |
| 2022-02-28 | 18466.18 | 未披露 | 定期报告 | 2022-01-31 |
| 2022-02-28 | 18435.00 | 未披露 |
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From December 31, 2020 to December 31, 2021
Exercise of stock options, 3,299,000 shares, net
Employee stock purchase plan sales, 321,000 shares, net
Issuance of common stock associated with royalty financing agreement, 3,846,000 shares, net
|
2021-12-31 |
| 2021-11-04 | 17993.62 | 未披露 | 定期报告 | 2021-10-29 |
| 2021-11-04 | 17979.10 | 未披露 |
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From June 30, 2021 to September 30, 2021
Employee stock purchase plan sales, 123 shares, net
Exercise of stock options, 942 shares, net
|
2021-09-30 |
| 2021-08-09 | 17886.99 | 未披露 | 定期报告 | 2021-07-30 |
| 2021-08-09 | 17872.50 | 未披露 |
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From March 31, 2021 to June 30, 2021
Exercise of stock options, 1,056 shares, net
|
2021-06-30 |
| 2021-05-07 | 17769.65 | 未披露 | 定期报告 | 2021-04-30 |
| 2021-05-07 | 17767.00 | 未披露 |
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From December 31, 2020 To March 31, 2021
Employee stock purchase plan sales, 193 shares, net
Exercise of stock options, 593 shares, net
|
2021-03-31 |
| 2021-04-13 | 17764.81 | 未披露 | 定期报告 | 2021-03-30 |
| 2021-03-01 | 17752.17 | 未披露 | 定期报告 | 2021-02-24 |
| 2021-03-01 | 17718.28 | 未披露 | 定期报告 | 2021-01-31 |
| 2021-03-01 | 17688.30 | 未披露 |
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from December 31, 2019 to December 31, 2020
Exercise of stock options, 510 shares, net
Employee stock purchase plan sales, 246 shares, net
Issuance of common stock, 22,044 shares, net
|
2020-12-31 |
| 2020-11-06 | 17656.56 | 未披露 | 定期报告 | 2020-10-31 |
| 2020-11-06 | 17656.60 | 未披露 |
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From June 30, 2020 to September 30, 2020
Employee stock purchase plan sales, 137 shares, net
|
2020-09-30 |
| 2020-08-10 | 17656.56 | 未披露 | 定期报告 | 2020-07-31 |
| 2020-08-10 | 17642.90 | 未披露 |
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From March 31, 2020 to June 30, 2020
Exercise of stock options, 193 shares, net
Issuance of common stock, 22,044 shares, net
|
2020-06-30 |
| 2020-06-01 | 17306.78 | 未披露 |
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1.Common stock offered 18,711,113 shares of common stock
2.The number of shares of our common stock to be outstanding after this offering is based on 154,356,644 shares outstanding as of May 26, 2020
|
2020-06-01 |
| 2020-05-27 | 15435.66 | 未披露 | 定期报告 | 2020-05-26 |
| 2020-05-11 | 15425.32 | 未披露 | 定期报告 | 2020-04-30 |
| 2020-04-24 | 15425.72 | 未披露 | 定期报告 | 2020-04-22 |
| 2020-05-11 | 15419.20 | 未披露 |
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From December 31, 2019 to March 31, 2020
Employee stock purchase plan sales, 110,000 shares, net
|
2020-03-31 |
| 2020-03-13 | 15419.20 | 未披露 | 定期报告 | 2020-01-31 |
| 2020-03-13 | 15408.20 | 未披露 |
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from December 31, 2018 to December 31, 2019
Exercise of stock options, 283 shares, net
Employee stock purchase plan sales, 115 shares, net
Issuance of common stock, 43,621 shares, net
|
2019-12-31 |
| 2019-11-21 | 15405.91 | 未披露 | 定期报告 | 2019-11-21 |
| 2019-11-18 | 14836.95 | 未披露 | 定期报告 | 2019-11-18 |
| 2019-11-08 | 11043.84 | 未披露 | 定期报告 | 2019-10-31 |
| 2019-11-08 | 11043.80 | 未披露 | 定期报告 | 2019-09-30 |
| 2019-08-08 | 11043.84 | 未披露 | 定期报告 | 2019-07-31 |
| 2019-08-08 | 11037.00 | 未披露 |
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From March 31, 2019 to June 30, 2019
Exercise of stock options, 100 shares, net
|
2019-06-30 |
| 2019-05-09 | 11031.29 | 未披露 | 定期报告 | 2019-04-30 |
| 2019-04-17 | 11027.03 | 未披露 | 定期报告 | 2019-04-01 |
| 2019-05-09 | 11027.00 | 未披露 |
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from December 31, 2018 to March 31, 2019
Exercise of stock options, 160 shares, net
|
2019-03-31 |
| 2019-03-14 | 11017.66 | 未披露 | 定期报告 | 2019-01-31 |
| 2019-03-14 | 11006.30 | 未披露 |
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from December 31, 2017 to December 31, 2018
Exercise of stock options, 1,106 shares, net
Employee stock purchase plan sales, 92 shares, net
Issuance of common stock, 10,455 shares, net
|
2018-12-31 |
| 2018-11-08 | 10964.10 | 未披露 | 定期报告 | 2018-10-31 |
| 2018-11-08 | 10962.50 | 未披露 | 定期报告 | 2018-09-30 |
| 2018-09-28 | 10959.42 | 未披露 | 定期报告 | 2018-09-19 |
| 2018-08-06 | 10938.21 | 未披露 | 定期报告 | 2018-08-06 |
| 2018-08-09 | 9892.76 | 未披露 | 定期报告 | 2018-07-31 |
| 2018-08-09 | 9892.80 | 未披露 | 定期报告 | 2018-06-30 |
| 2018-05-09 | 9871.69 | 未披露 | 定期报告 | 2018-04-30 |
| 2018-05-09 | 9870.20 | 未披露 | 定期报告 | 2018-03-31 |
| 2018-03-12 | 9860.61 | 未披露 | 定期报告 | 2018-01-31 |
| 2018-03-12 | 9841.10 | 未披露 |
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from December 31, 2016 to December 31, 2017
Exercise of stock options, 609 shares, net
Employee stock purchase plan sales, 95 shares, net
Issuance of common stock, 23,925 shares, net
|
2017-12-31 |
| 2017-11-08 | 9840.48 | 未披露 | 定期报告 | 2017-11-06 |
| 2017-11-08 | 9840.48 | 未披露 | 定期报告 | 2017-10-31 |
| 2017-11-08 | 9838.90 | 未披露 | 定期报告 | 2017-09-30 |
| 2017-08-08 | 8042.81 | 未披露 | 定期报告 | 2017-07-31 |
| 2017-08-08 | 8042.80 | 未披露 | 定期报告 | 2017-06-30 |
| 2017-05-10 | 8042.14 | 未披露 | 定期报告 | 2017-05-08 |
| 2017-05-08 | 8042.06 | 未披露 | 定期报告 | 2017-04-30 |
| 2017-05-08 | 8038.10 | 未披露 | 定期报告 | 2017-03-31 |
| 2017-04-12 | 8037.81 | 未披露 | 定期报告 | 2017-03-28 |
| 2017-02-27 | 7395.52 | 未披露 | 定期报告 | 2017-01-31 |
| 2017-02-27 | 7378.20 | 未披露 |
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from December 31, 2015 to December 31, 2016
Exercise of stock options, 351 shares, net
Employee stock purchase plan sales, 75 shares, net
|
2016-12-31 |
| 2016-11-08 | 7375.83 | 未披露 | 定期报告 | 2016-10-31 |
| 2016-11-08 | 7375.80 | 未披露 | 定期报告 | 2016-09-30 |
| 2016-08-08 | 7370.05 | 未披露 | 定期报告 | 2016-07-31 |
| 2016-08-08 | 7370.10 | 未披露 | 定期报告 | 2016-06-30 |
| 2016-05-09 | 7369.28 | 未披露 | 定期报告 | 2016-04-30 |
| 2016-05-09 | 7369.30 | 未披露 | 定期报告 | 2016-03-31 |
| 2016-04-11 | 7368.78 | 未披露 | 定期报告 | 2016-03-28 |
| 2016-02-26 | 7362.98 | 未披露 | 定期报告 | 2016-01-31 |
| 2016-02-26 | 7335.50 | 未披露 |
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From December 31, 2014 to December 31, 2015
Exercise of stock options, 1,359 shares, net
|
2015-12-31 |
| 2015-11-06 | 7333.69 | 未披露 | 定期报告 | 2015-10-31 |
| 2015-11-06 | 7333.70 | 未披露 | 定期报告 | 2015-09-30 |
| 2015-08-07 | 7323.94 | 未披露 | 定期报告 | 2015-07-31 |
| 2015-08-07 | 7316.80 | 未披露 | 定期报告 | 2015-06-30 |
| 2015-05-08 | 7252.05 | 未披露 | 定期报告 | 2015-04-30 |
| 2015-05-08 | 7247.40 | 未披露 | 定期报告 | 2015-03-31 |
| 2015-04-10 | 7245.84 | 未披露 | 定期报告 | 2015-03-27 |
| 2015-03-03 | 7232.01 | 未披露 | 定期报告 | 2015-01-31 |
| 2015-03-02 | 7195.50 | 未披露 |
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from December 31, 2013 to December 31, 2014
Exercise of stock options, 1,314 shares, net
Employee stock purchase plan sales, 49 shares, net
Issuance of common stock, 11,500 shares, net
|
2014-12-31 |
| 2014-11-07 | 7186.38 | 未披露 | 定期报告 | 2014-10-31 |
| 2014-11-07 | 7186.10 | 未披露 | 定期报告 | 2014-09-30 |
| 2014-08-08 | 7175.63 | 未披露 | 定期报告 | 2014-07-31 |
| 2014-08-08 | 7171.80 | 未披露 | 定期报告 | 2014-06-30 |
| 2014-05-09 | 6006.46 | 未披露 | 定期报告 | 2014-04-30 |
| 2014-05-09 | 6006.50 | 未披露 | 定期报告 | 2014-03-31 |
| 2014-03-21 | 5994.92 | 未披露 | 定期报告 | 2014-03-10 |
| 2014-03-10 | 5938.45 | 未披露 | 定期报告 | 2014-01-31 |
| 2014-03-10 | 5909.20 | 未披露 |
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from December 31, 2012 to December 31, 2013
Exercise of stock options, 563 shares, net
Employee stock purchase plan sales, 89 shares, net
Issuance of common stock, 7,547 shares, net
|
2013-12-31 |
| 2013-11-06 | 5909.14 | 未披露 | 定期报告 | 2013-10-28 |
| 2013-11-08 | 5909.10 | 未披露 | 定期报告 | 2013-09-30 |
| 2013-08-08 | 5423.67 | 未披露 | 定期报告 | 2013-07-31 |
| 2013-08-08 | 5419.70 | 未披露 | 定期报告 | 2013-06-30 |
| 2013-05-09 | 5314.71 | 未披露 | 定期报告 | 2013-04-30 |
| 2013-04-16 | 5140.54 | 未披露 | 定期报告 | 2013-04-05 |
| 2013-05-09 | 5140.50 | 未披露 | 定期报告 | 2013-03-31 |
| 2013-03-11 | 5092.81 | 未披露 | 定期报告 | 2013-01-31 |
| 2013-03-11 | 5089.30 | 未披露 |
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from December 31, 2011 to December 31, 2012
Exercise of stock options, 348 shares, net
Employee stock purchase plan sales, 110 shares, net
Issuance of common stock, 4,774 shares, net
|
2012-12-31 |
| 2012-11-08 | 5087.98 | 未披露 | 定期报告 | 2012-10-31 |
| 2012-11-08 | 5088.00 | 未披露 | 定期报告 | 2012-09-30 |
| 2012-08-08 | 5049.38 | 未披露 | 定期报告 | 2012-07-31 |
| 2012-08-08 | 5013.40 | 未披露 | 定期报告 | 2012-06-30 |
| 2012-05-08 | 4917.02 | 未披露 | 定期报告 | 2012-04-30 |
| 2012-05-08 | 4915.50 | 未披露 | 定期报告 | 2012-03-31 |
| 2012-03-06 | 4603.78 | 未披露 | 定期报告 | 2012-01-31 |
| 2012-03-06 | 4566.20 | 未披露 |
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from December 31, 2010 to December 31, 2011
Exercise of stock options, 184 shares, net
Employee stock purchase plan sales, 94 shares
Issuance of common stock, 437 shares, net
|
2011-12-31 |
| 2011-11-03 | 4521.34 | 未披露 | 定期报告 | 2011-11-01 |
| 2011-11-03 | 4519.50 | 未披露 | 定期报告 | 2011-09-30 |
| 2011-08-04 | 4514.99 | 未披露 | 定期报告 | 2011-08-01 |
| 2011-08-04 | 4515.00 | 未披露 | 定期报告 | 2011-06-30 |
| 2011-05-06 | 4509.80 | 未披露 | 定期报告 | 2011-04-22 |
| 2011-05-06 | 4509.80 | 未披露 | 定期报告 | 2011-03-31 |
| 2011-03-15 | 4504.40 | 未披露 | 定期报告 | 2011-03-07 |
| 2011-03-15 | 4495.90 | 未披露 |
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from December 31, 2009 to December 31, 2010
Exercise of stock options, 240,314 shares, net
Employee stock purchase plan sales, 51,329 shares
Issuance of common stock, 761,326 shares, net
Purchases of treasury stock, 812 shares
|
2010-12-31 |
| 2010-11-08 | 4492.34 | 未披露 | 定期报告 | 2010-10-27 |
| 2010-11-08 | 4492.30 | 未披露 | 定期报告 | 2010-09-30 |
| 2010-08-06 | 4491.54 | 未披露 | 定期报告 | 2010-07-30 |
| 2010-08-06 | 4489.40 | 未披露 | 定期报告 | 2010-06-30 |
| 2010-03-09 | 4395.72 | 未披露 | 定期报告 | 2010-03-01 |
| 2010-03-09 | 4390.68 | 未披露 |
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from December 31, 2008 to December 31, 2009
Exercise of stock options, 532,379 shares, net
Sale of common stock, 5,000,000 shares, net
Employee stock purchase plan sales, 123,357 shares
Purchases of treasury stock, 24,072 shares
|
2009-12-31 |
| 2009-03-06 | 3833.13 | 未披露 | 定期报告 | 2009-02-20 |
| 2009-03-06 | 3827.52 | 未披露 |
更多>>
from December 31, 2007 to December 31, 2008
Issue of restricted common stock, 76,536 shares
Exercise of stock options, 146,470 shares, net
Employee stock purchase plan sales, 84,907 shares
|
2008-12-31 |
| 2008-03-04 | 3808.09 | 未披露 | 定期报告 | 2008-02-20 |
| 2008-03-04 | 3796.73 | 未披露 |
更多>>
from December 31, 2006 to December 31, 2007
Issue of restricted common stock, 60,000 shares
Sale of common stock, 8,315,513 shares, net
Exercise of stock options, 308,037 shares, net
Employee stock purchase plan sales, 34,855 shares
|
2007-12-31 |
| 2007-03-14 | 2934.29 | 未披露 | 定期报告 | 2007-03-07 |
| 2007-03-14 | 2924.88 | 未披露 |
更多>>
from December 31, 2005 to December 31, 2006
Exercise of stock options, 409,328 shares, net
Employee stock purchase plan sales, 25,988 shares
|
2006-12-31 |
| 2006-03-09 | 2898.02 | 未披露 | 定期报告 | 2006-03-03 |
| 2006-03-09 | 2881.35 | 未披露 |
更多>>
from December 31, 2004 to December 31, 2005
Sale of common stock, 6,578,829 shares
Exercise of stock options, 450,717 shares, net
Employee stock purchase plan sales, 25,700 shares
|
2005-12-31 |
| 2005-03-16 | 2614.74 | 未披露 | 定期报告 | 2005-02-23 |
| 2005-03-16 | 2175.83 | 未披露 |
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from December 31, 2003 to December 31, 2004
Sale of common stock, 3,571,667 shares
Exercise of stock options, 283,636 shares, net
Employee stock purchase plan sales, 31,695 shares
|
2004-12-31 |
| 2004-03-19 | 2147.46 | 未披露 | 定期报告 | 2004-02-27 |
| 2004-03-19 | 1787.13 | 未披露 |
更多>>
from December 31, 2002 to December 31, 2003
Exercise of stock options, 186,228 shares, net
Employee stock purchase plan sales, 27,964 shares
|
2003-12-31 |
| 2003-03-21 | 1766.57 | 未披露 | 定期报告 | 2003-02-28 |
| 2003-03-21 | 1765.71 | 未披露 |
更多>>
from December 31, 2001 to December 31, 2002
Employee stock purchase plan sales, 50,127 shares
|
2002-12-31 |
| 2002-03-25 | 1763.65 | 未披露 | 定期报告 | 2002-03-01 |
| 2002-03-25 | 1760.70 | 未披露 |
更多>>
from December 31, 2000 to December 31, 2001
Exercise of stock options, 46,027 shares, net
Employee stock purchase plan sales, 24,122 shares
|
2001-12-31 |
| 2001-03-28 | 1754.00 | 未披露 | 定期报告 | 2001-03-20 |
| 2001-03-28 | 1753.68 | 未披露 |
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from December 31, 1999 to December 31, 2000
Exercise of stock options, 255,170 shares, net
Employee stock purchase plan sales, 17,773 shares
|
2000-12-31 |
| 2000-03-27 | 1743.00 | 未披露 | 定期报告 | 2000-03-20 |
| 2000-03-27 | 1726.39 | 未披露 |
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from December 31, 1998 to December 31, 1999
Sale of common stock, 2,000,000 shares
Exercise of stock options, 277,814 shares
Employee stock purchase plan sales, 26,056 shares
|
1999-12-31 |
| 1999-03-31 | 1498.70 | 未披露 | 定期报告 | 1999-03-15 |
| 1999-03-31 | 1496.01 | 未披露 |
更多>>
from December 31, 1997 to December 31, 1998
Sale of common stock, 918,836 shares
Exercise of stock options, 144,102 shares
Employee stock purchase plan sales, 23,597 shares
Exercise of warrants, 55,806 shares
|
1998-12-31 |
| 1998-03-24 | 1394.02 | 未披露 | 定期报告 | 1998-03-22 |
| 1998-03-24 | 1381.77 | 未披露 |
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from December 31, 1996 to December 31, 1997
Exercise of stock options, 79,670 shares
Employee stock purchase plan sales, 15,933 shares
Exercise of warrants, 24,330 shares
|
1997-12-31 |
| 1997-03-28 | 1377.06 | 未披露 | 定期报告 | 1997-03-15 |
| 1997-03-28 | 1369.77 | 未披露 |
更多>>
from December 31, 1995 to December 31, 1996
Sale of common stock, 3,376,608 shares
Exercise stock options, 45,255 shares
Employee stock purchase plan sales, 18,101 shares
Exercise of warrants, 753,439 shares
|
1996-12-31 |
| 1996-09-24 | 951.24 | 未披露 | 定期报告 | 1996-01-31 |
| 1996-09-24 | 950.43 | 未披露 |
更多>>
from December 31, 1994 to December 31, 1995
Sale of 1,570,000 shares of common stock at $5.50 per share, less issuance cost
Exercise of 13,834 shares of common stock under the stock option plan
Sale of 13,331 shares of common stock under the employee stock purchase plan at $4.94 per share
|
1995-12-31 |
| 1996-09-24 | 790.72 | 未披露 |
更多>>
from December 31, 1993 to December 31, 1994
Sale of 2,310,900 shares of common stock at $6.50 per share, less issuance cost
Conversion of Series A Preferred Stock into 709,160 shares of common stock upon the Company's IPO
Conversion of Series B Preferred Stock into 994,165 shares of common stock upon the Company's IPO
Sale of 515,000 shares of common stock at $3.88 per share, less issuance cost
Exercise of 99,540 shares of common stock under the stock option plan,less 36,796 shares exchanged
|
1994-12-31 |
From March 31,2026 to June 30,2026
Exercise of stock options
Issuance of shares to directors in lieu of cash retainer
Shares withheld for taxes for vesting of restricted stock units
Vesting of restricted stock units
From December 31, 2025 to March 31, 2026
Exercise of stock options
Vesting of restricted stock units
Employee stock purchase plan sales
Issuance of shares to directors in lieu of cash retainer
Issuance of common stock for the acquisition of Astria Therapeutics, Inc.
Common Stock offered 37,300,000 shares by the company
From December 31, 2024 to December 31, 2025
Exercise of stock options, net
Vesting of restricted stock units
Shares withheld for taxes for vesting of restricted stock units
Employee stock purchase plan sales
Issuance of shares to directors in lieu of cash retainer
From June 30, 2025 to September 30, 2025
Exercise of stock options, net
Vesting of restricted stock units
Employee stock purchase plan sales
Issuance of shares to directors in lieu of cash retainer
From March 31, 2025 to June 30, 2025
Exercise of stock options
Vesting of restricted stock units
Issuance of shares to directors in lieu of cash retainer
From December 31, 2024 to March 31, 2025
Exercise of stock options
Vesting of restricted stock units
Shares withheld for taxes for vesting of restricted stock units
Employee stock purchase plan sales
Issuance of shares to directors in lieu of cash retainer
From December 31, 2023 to December 31, 2024
Exercise of stock options
Vesting of restricted stock units
Shares withheld for taxes for vesting of restricted stock units
Employee stock purchase plan sales
Issuance of shares to directors in lieu of cash retainer
From June 30, 2024 to September 30, 2024
Exercise of stock options
Vesting of restricted stock units
Employee stock purchase plan sales
Issuance of shares to directors in lieu of cash retainer
From March 31, 2024 to June 30, 2024
Exercise of stock options, net
Vesting of restricted stock units
Issuance of shares to directors in lieu of cash retainer
From December 31, 2023 to March 31, 2024
Exercise of stock options, net
Vesting of restricted stock units
Issuance of shares to directors in lieu of cash retainer
Shares withheld for taxes for vesting of restricted stock units
Employee stock purchase plan sales
From December 31, 2022 to December 31, 2023
Exercise of stock options, 1,276 shares, net
Vesting of restricted stock units, 1,276 shares
Shares withheld for taxes for vesting of restricted stock units, 59 shares
Employee stock purchase plan sales, 338 shares, net
Exercise of warrants, 14,997 shares
From June 30, 2023 to September 30, 2023
Employee stock purchase plan sales, 162 shares, net
Exercise of stock awards, 149 shares, net
From March 31, 2023 to June 30, 2023
Exercise of stock options, 608 shares, net
From December 31, 2022 to March 31, 2023
Employee stock purchase plan sales, 176 shares, net
Exercise of stock options, 801 shares, net
From December 31, 2021 to December 31, 2022
Exercise of stock options, 3,044 shares, net
Employee stock purchase plan sales, 260 shares, net
Exercise of warrants, 253 shares
From June 30, 2022 to September 30, 2022
Employee stock purchase plan sales, 145 shares, net
Exercise of stock options, 390 shares, net
From March 31, 2022 to June 30, 2022
Exercise of warrants, 253 shares
From December 31, 2021 to March 31, 2022
Employee stock purchase plan sales, 115 shares, net
Exercise of stock options, 1,108 shares, net
From December 31, 2020 to December 31, 2021
Exercise of stock options, 3,299,000 shares, net
Employee stock purchase plan sales, 321,000 shares, net
Issuance of common stock associated with royalty financing agreement, 3,846,000 shares, net
From June 30, 2021 to September 30, 2021
Employee stock purchase plan sales, 123 shares, net
Exercise of stock options, 942 shares, net
From March 31, 2021 to June 30, 2021
Exercise of stock options, 1,056 shares, net
From December 31, 2020 To March 31, 2021
Employee stock purchase plan sales, 193 shares, net
Exercise of stock options, 593 shares, net
from December 31, 2019 to December 31, 2020
Exercise of stock options, 510 shares, net
Employee stock purchase plan sales, 246 shares, net
Issuance of common stock, 22,044 shares, net
From June 30, 2020 to September 30, 2020
Employee stock purchase plan sales, 137 shares, net
From March 31, 2020 to June 30, 2020
Exercise of stock options, 193 shares, net
Issuance of common stock, 22,044 shares, net
1.Common stock offered 18,711,113 shares of common stock
2.The number of shares of our common stock to be outstanding after this offering is based on 154,356,644 shares outstanding as of May 26, 2020
From December 31, 2019 to March 31, 2020
Employee stock purchase plan sales, 110,000 shares, net
from December 31, 2018 to December 31, 2019
Exercise of stock options, 283 shares, net
Employee stock purchase plan sales, 115 shares, net
Issuance of common stock, 43,621 shares, net
From March 31, 2019 to June 30, 2019
Exercise of stock options, 100 shares, net
from December 31, 2018 to March 31, 2019
Exercise of stock options, 160 shares, net
from December 31, 2017 to December 31, 2018
Exercise of stock options, 1,106 shares, net
Employee stock purchase plan sales, 92 shares, net
Issuance of common stock, 10,455 shares, net
from December 31, 2016 to December 31, 2017
Exercise of stock options, 609 shares, net
Employee stock purchase plan sales, 95 shares, net
Issuance of common stock, 23,925 shares, net
from December 31, 2015 to December 31, 2016
Exercise of stock options, 351 shares, net
Employee stock purchase plan sales, 75 shares, net
From December 31, 2014 to December 31, 2015
Exercise of stock options, 1,359 shares, net
from December 31, 2013 to December 31, 2014
Exercise of stock options, 1,314 shares, net
Employee stock purchase plan sales, 49 shares, net
Issuance of common stock, 11,500 shares, net
from December 31, 2012 to December 31, 2013
Exercise of stock options, 563 shares, net
Employee stock purchase plan sales, 89 shares, net
Issuance of common stock, 7,547 shares, net
from December 31, 2011 to December 31, 2012
Exercise of stock options, 348 shares, net
Employee stock purchase plan sales, 110 shares, net
Issuance of common stock, 4,774 shares, net
from December 31, 2010 to December 31, 2011
Exercise of stock options, 184 shares, net
Employee stock purchase plan sales, 94 shares
Issuance of common stock, 437 shares, net
from December 31, 2009 to December 31, 2010
Exercise of stock options, 240,314 shares, net
Employee stock purchase plan sales, 51,329 shares
Issuance of common stock, 761,326 shares, net
Purchases of treasury stock, 812 shares
from December 31, 2008 to December 31, 2009
Exercise of stock options, 532,379 shares, net
Sale of common stock, 5,000,000 shares, net
Employee stock purchase plan sales, 123,357 shares
Purchases of treasury stock, 24,072 shares
from December 31, 2007 to December 31, 2008
Issue of restricted common stock, 76,536 shares
Exercise of stock options, 146,470 shares, net
Employee stock purchase plan sales, 84,907 shares
from December 31, 2006 to December 31, 2007
Issue of restricted common stock, 60,000 shares
Sale of common stock, 8,315,513 shares, net
Exercise of stock options, 308,037 shares, net
Employee stock purchase plan sales, 34,855 shares
from December 31, 2005 to December 31, 2006
Exercise of stock options, 409,328 shares, net
Employee stock purchase plan sales, 25,988 shares
from December 31, 2004 to December 31, 2005
Sale of common stock, 6,578,829 shares
Exercise of stock options, 450,717 shares, net
Employee stock purchase plan sales, 25,700 shares
from December 31, 2003 to December 31, 2004
Sale of common stock, 3,571,667 shares
Exercise of stock options, 283,636 shares, net
Employee stock purchase plan sales, 31,695 shares
from December 31, 2002 to December 31, 2003
Exercise of stock options, 186,228 shares, net
Employee stock purchase plan sales, 27,964 shares
from December 31, 2001 to December 31, 2002
Employee stock purchase plan sales, 50,127 shares
from December 31, 2000 to December 31, 2001
Exercise of stock options, 46,027 shares, net
Employee stock purchase plan sales, 24,122 shares
from December 31, 1999 to December 31, 2000
Exercise of stock options, 255,170 shares, net
Employee stock purchase plan sales, 17,773 shares
from December 31, 1998 to December 31, 1999
Sale of common stock, 2,000,000 shares
Exercise of stock options, 277,814 shares
Employee stock purchase plan sales, 26,056 shares
from December 31, 1997 to December 31, 1998
Sale of common stock, 918,836 shares
Exercise of stock options, 144,102 shares
Employee stock purchase plan sales, 23,597 shares
Exercise of warrants, 55,806 shares
from December 31, 1996 to December 31, 1997
Exercise of stock options, 79,670 shares
Employee stock purchase plan sales, 15,933 shares
Exercise of warrants, 24,330 shares
from December 31, 1995 to December 31, 1996
Sale of common stock, 3,376,608 shares
Exercise stock options, 45,255 shares
Employee stock purchase plan sales, 18,101 shares
Exercise of warrants, 753,439 shares
from December 31, 1994 to December 31, 1995
Sale of 1,570,000 shares of common stock at $5.50 per share, less issuance cost
Exercise of 13,834 shares of common stock under the stock option plan
Sale of 13,331 shares of common stock under the employee stock purchase plan at $4.94 per share
from December 31, 1993 to December 31, 1994
Sale of 2,310,900 shares of common stock at $6.50 per share, less issuance cost
Conversion of Series A Preferred Stock into 709,160 shares of common stock upon the Company's IPO
Conversion of Series B Preferred Stock into 994,165 shares of common stock upon the Company's IPO
Sale of 515,000 shares of common stock at $3.88 per share, less issuance cost
Exercise of 99,540 shares of common stock under the stock option plan,less 36,796 shares exchanged