股本结构
单位：万股
| 公告日期 | 2026-05-14 | 2026-03-19 | 2026-02-27 | 2026-03-19 | 2025-11-05 | 2025-07-31 |
|---|---|---|---|---|---|---|
| 证券总股本 | 10388.29 | 10388.29 | 10609.04 | 8309.04 | 8559.04 | 8277.79 |
| 普通股本 | 10388.29 | 10388.29 | 10609.04 | 8309.04 | 8559.04 | 8277.79 |
| 优先股 | 50.00 | 未披露 | 未披露 | 25.00 | 未披露 | 未披露 |
| 其他 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 | 未披露 |
| 变动日期 | 2026-03-31 | 2026-03-17 | 2026-02-27 | 2025-12-31 | 2025-09-30 | 2025-07-31 |
注释：中概股证券总股本=普通股股本/
存托凭证比例
历史变动
| 公告日期 | 变动后普通股本（万股） | 变动后优先股（万股） | 变动原因 | 变动日期 |
|---|---|---|---|---|
| 2026-05-14 | 10388.29 | 50.00 |
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From December 31,2025 to March 31,2026
Issuance of preferred stock in exchange for common stock
Issuance of common stock, net of issuance costs
Vesting of restricted stock units
Exercise of stock options
|
2026-03-31 |
| 2026-03-19 | 10388.29 | 未披露 | 定期报告 | 2026-03-17 |
| 2026-02-27 | 10609.04 | 未披露 |
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Common Stock offered 20,000,000 shares by the company
The underwriters exercised their option to purchase common stock 3,000,000 shares
|
2026-02-27 |
| 2026-03-19 | 8309.04 | 25.00 |
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From December 31, 2024 to December 31, 2025
Issuance of Series A preferred stock in exchange for common stock
Issuance of common stock, net
Vesting of restricted stock units, net of employee tax obligations
|
2025-12-31 |
| 2025-11-05 | 8559.04 | 未披露 |
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From June 30, 2025 to September 30, 2025
Issuance of common stock, net
|
2025-09-30 |
| 2025-07-31 | 8277.79 | 未披露 |
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Common Stock offered 18,750,000 shares by the company
|
2025-07-31 |
| 2025-04-30 | 6402.79 | 未披露 |
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From December 31, 2024 to March 31, 2025
Vesting of restricted stock units
|
2025-03-31 |
| 2025-03-24 | 6402.79 | 未披露 | 定期报告 | 2025-03-20 |
| 2025-03-24 | 6381.51 | 未披露 |
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From December 31, 2023 to December 31, 2024
Issuance of common stock, net
Vesting of restricted stock units
Exercise of stock options
|
2024-12-31 |
| 2024-10-30 | 6380.66 | 未披露 |
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From June 30, 2024 to September 30, 2024
Exercise of stock options
|
2024-09-30 |
| 2024-08-08 | 6380.66 | 未披露 | 定期报告 | 2024-08-06 |
| 2024-08-08 | 6380.25 | 未披露 |
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From March 31, 2024 to June 30, 2024
Exercise of stock options
|
2024-06-30 |
| 2024-05-09 | 6380.20 | 未披露 | 定期报告 | 2024-05-07 |
| 2024-05-09 | 6380.00 | 未披露 |
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From December 31, 2023 to March 31, 2024
Issuance of common stock, net
Vesting of restricted stock units
Exercise of stock options
|
2024-03-31 |
| 2024-03-14 | 6380.00 | 未披露 | 定期报告 | 2024-03-12 |
| 2024-02-14 | 6106.84 | 未披露 |
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Common stock offered 17,162,472 shares by the company
|
2024-02-16 |
| 2024-03-14 | 4390.91 | 未披露 |
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From December 31, 2022 to December 31, 2023
Exercise of stock options
Exercise of warrants
|
2023-12-31 |
| 2023-11-14 | 4390.59 | 未披露 |
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From June 30, 2023 to September 30, 2023
Exercise of stock options
Exercise of warrants
|
2023-09-30 |
| 2023-08-10 | 4327.75 | 未披露 | 定期报告 | 2023-08-07 |
| 2022-11-10 | 4326.92 | 未披露 |
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From June 30, 2022 to September 30, 2022
Issuance of Common Stock, net
|
2022-09-30 |
| 2022-09-14 | 3993.55 | 未披露 | 定期报告 | 2022-09-16 |
| 2021-11-12 | 1771.05 | 未披露 |
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From June 30, 2021 to September 30, 2021
Issuance of Common Stock, net
|
2021-09-30 |
| 2021-08-12 | 1771.05 | 未披露 | 定期报告 | 2021-08-10 |
| 2021-03-04 | 1536.77 | 未披露 |
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From December 31,2019 to December 31,2020
Merger with Zafgen Inc.
Private Placement, net of transaction costs
Issuance of Common Stock to placement agent for advisory fees in lieu of cash and other issuances of common stock
|
2020-12-31 |
| 2020-08-14 | 1535.62 | 未披露 |
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From March 31, 2020 to June 30, 2020
Merger with Zafgen Inc.
Private Placement of common shares and pre-funded warrants, net of transaction costs
|
2020-06-30 |
| 2020-06-26 | 1535.43 | 未披露 | 定期报告 | 2020-06-26 |
| 2020-06-02 | 312.25 | 未披露 |
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On May 28, 2020, prior to the closing of the Merger, the Company filed the Stock Split Amendment with the Secretary of State of the State of Delaware to effect the Reverse Stock Split and the Company filed an amendment to the ninth amended and restated certificate of incorporation with the Secretary of State of the State of Delaware to effect the Name Change (the “Name Change Amendment”). As a result of the Reverse Stock Split, the number of issued and outstanding shares of the Company’s Common Stock immediately prior to the Reverse Stock Split was reduced to a smaller number of shares, such that every twelve shares of the Company’s Common Stock held by a stockholder immediately prior to the Reverse Stock Split were combined and reclassified into one share of the Company’s Common Stock. Immediately following the Reverse Stock Split, but prior to the completion of the Merger and Private Placement, there were approximately 3,122,466 shares of Zafgen Common Stock outstanding.
|
2020-05-29 |
| 2020-05-07 | 3746.96 | 未披露 |
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From December 31, 2019 to March 01, 2020
Issuance of common stock upon exercise of stock options and employee stock purchase plan
Issuance of restricted stock units
|
2020-03-01 |
| 2020-03-05 | 3744.65 | 未披露 |
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from December 31, 2018 to December 31, 2019
Issuance of common stock upon exercise of stock options and employee stock purchase plan
Issuance of restricted stock units
|
2019-12-31 |
| 2019-11-06 | 3737.41 | 未披露 | 定期报告 | 2019-10-31 |
| 2019-11-06 | 3737.03 | 未披露 |
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From June 30, 2019 to September 30, 2019
Issuance of common stock upon exercise of stock options and employee stock purchase plan
Issuance of restricted stock units
|
2019-09-30 |
| 2019-08-08 | 3737.03 | 未披露 | 定期报告 | 2019-07-31 |
| 2019-08-08 | 3732.69 | 未披露 |
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From March 31, 2019 to June 30, 2019
Issuance of restricted stock units
|
2019-06-30 |
| 2019-04-26 | 3732.69 | 未披露 | 定期报告 | 2019-04-15 |
| 2019-05-09 | 3732.31 | 未披露 |
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from December 31, 2018 to March 31, 2019
Issuance of common stock upon exercise of stock options and employee stock purchase plan
Issuance of restricted stock units
|
2019-03-31 |
| 2019-03-14 | 3731.51 | 未披露 | 定期报告 | 2019-03-01 |
| 2019-03-14 | 3728.72 | 未披露 |
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from December 31, 2017 to December 31, 2018
Issuance of common stock, net of issuance costs
Issuance of common stock upon exercise of stock options and employee stock purchase plan
Issuance of restricted stock units
|
2018-12-31 |
| 2018-11-09 | 3687.08 | 未披露 | 定期报告 | 2018-11-08 |
| 2018-11-09 | 3687.08 | 未披露 | 定期报告 | 2018-10-31 |
| 2018-11-09 | 3686.58 | 未披露 | 定期报告 | 2018-09-30 |
| 2018-08-09 | 3680.56 | 未披露 | 定期报告 | 2018-07-31 |
| 2018-08-09 | 2757.90 | 未披露 | 定期报告 | 2018-06-30 |
| 2018-04-18 | 2756.33 | 未披露 | 定期报告 | 2018-04-02 |
| 2018-05-10 | 2755.89 | 未披露 | 定期报告 | 2018-03-31 |
| 2018-03-09 | 2755.89 | 未披露 | 定期报告 | 2018-03-01 |
| 2018-03-09 | 2748.95 | 未披露 |
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from December 31, 2016 to December 31, 2017
Issuance of common stock upon exercise of stock options and employee stock purchase plan
Issuance of common stock upon exercise of stock options and employee stock purchase plan
|
2017-12-31 |
| 2017-11-07 | 2748.95 | 未披露 | 定期报告 | 2017-10-31 |
| 2017-11-07 | 2748.39 | 未披露 | 定期报告 | 2017-09-30 |
| 2017-08-09 | 2748.39 | 未披露 | 定期报告 | 2017-07-31 |
| 2017-08-09 | 2744.95 | 未披露 | 定期报告 | 2017-06-30 |
| 2017-04-28 | 2737.29 | 未披露 | 定期报告 | 2017-04-03 |
| 2017-05-09 | 2735.07 | 未披露 | 定期报告 | 2017-03-31 |
| 2017-03-10 | 2735.07 | 未披露 | 定期报告 | 2017-03-01 |
| 2017-03-10 | 2733.26 | 未披露 |
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From December 31, 2015 to December 31, 2016
Issuance of common stock upon exercise of stock options and employee stock purchase plan
Issuance of common stock
Issuance of restricted stock units
|
2016-12-31 |
| 2016-11-09 | 2733.26 | 未披露 | 定期报告 | 2016-10-31 |
| 2016-11-09 | 2732.92 | 未披露 | 定期报告 | 2016-09-30 |
| 2016-08-05 | 2732.92 | 未披露 | 定期报告 | 2016-07-31 |
| 2016-08-04 | 2727.23 | 未披露 | 定期报告 | 2016-06-30 |
| 2016-04-29 | 2727.23 | 未披露 | 定期报告 | 2016-04-01 |
| 2016-05-10 | 2726.89 | 未披露 | 定期报告 | 2016-03-31 |
| 2016-03-15 | 2726.89 | 未披露 | 定期报告 | 2016-03-07 |
| 2016-03-15 | 2724.25 | 未披露 |
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From December 31, 2014 to December 31, 2015
Issuance of common stock
Issuance of common stock upon exercise of stock options and employee stock purchase plan
Issuance of restricted stock
|
2015-12-31 |
| 2015-11-13 | 2723.45 | 未披露 | 定期报告 | 2015-10-30 |
| 2015-08-14 | 2712.35 | 未披露 | 定期报告 | 2015-07-31 |
| 2015-04-30 | 2689.42 | 未披露 | 定期报告 | 2015-04-27 |
| 2015-03-25 | 2685.63 | 未披露 | 定期报告 | 2015-03-17 |
| 2014-11-13 | 2270.74 | 未披露 | 定期报告 | 2014-11-11 |
| 2014-06-19 | 2180.70 | 未披露 |
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A 1-for-6.28 reverse stock split of our common stock and a proportional adjustment to the existing conversion ratio of each series of our redeemable convertible preferred stock, which became effective on June 5, 2014.
The automatic conversion of all outstanding shares of our redeemable convertible preferred stock into an aggregate of 15,077,621 shares of our common stock upon the completion of this offering;
|
2014-06-19 |
| 2014-06-05 | 72.94 | 9468.75 |
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On June 5, 2014, the Company effected a 1-for-6.28 reverse stock split of its issued and outstanding shares of common stock and a proportional adjustment to the existing conversion ratios for each series of Redeemable Preferred Stock
|
2014-06-06 |
| 2014-05-02 | 458.07 | 9468.75 |
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from December 31, 2013 to March 31, 2014
Issuance of Series E redeemable convertible preferred stock, net of issuance costs of $1
|
2014-03-31 |
| 2014-04-18 | 458.07 | 9448.34 |
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from December 31,2012 to December 31,2013
Issuance of Series D redeemable convertible preferred stock, net of issuance costs of $1
Issuance of Series E redeemable convertible preferred stock, net of issuance costs of $156
Repurchase and retirement of common stock, at cost
|
2013-12-31 |
From December 31,2025 to March 31,2026
Issuance of preferred stock in exchange for common stock
Issuance of common stock, net of issuance costs
Vesting of restricted stock units
Exercise of stock options
Common Stock offered 20,000,000 shares by the company
The underwriters exercised their option to purchase common stock 3,000,000 shares
From December 31, 2024 to December 31, 2025
Issuance of Series A preferred stock in exchange for common stock
Issuance of common stock, net
Vesting of restricted stock units, net of employee tax obligations
From June 30, 2025 to September 30, 2025
Issuance of common stock, net
Common Stock offered 18,750,000 shares by the company
From December 31, 2024 to March 31, 2025
Vesting of restricted stock units
From December 31, 2023 to December 31, 2024
Issuance of common stock, net
Vesting of restricted stock units
Exercise of stock options
From June 30, 2024 to September 30, 2024
Exercise of stock options
From March 31, 2024 to June 30, 2024
Exercise of stock options
From December 31, 2023 to March 31, 2024
Issuance of common stock, net
Vesting of restricted stock units
Exercise of stock options
Common stock offered 17,162,472 shares by the company
From December 31, 2022 to December 31, 2023
Exercise of stock options
Exercise of warrants
From June 30, 2023 to September 30, 2023
Exercise of stock options
Exercise of warrants
From June 30, 2022 to September 30, 2022
Issuance of Common Stock, net
From June 30, 2021 to September 30, 2021
Issuance of Common Stock, net
From December 31,2019 to December 31,2020
Merger with Zafgen Inc.
Private Placement, net of transaction costs
Issuance of Common Stock to placement agent for advisory fees in lieu of cash and other issuances of common stock
From March 31, 2020 to June 30, 2020
Merger with Zafgen Inc.
Private Placement of common shares and pre-funded warrants, net of transaction costs
On May 28, 2020, prior to the closing of the Merger, the Company filed the Stock Split Amendment with the Secretary of State of the State of Delaware to effect the Reverse Stock Split and the Company filed an amendment to the ninth amended and restated certificate of incorporation with the Secretary of State of the State of Delaware to effect the Name Change (the “Name Change Amendment”). As a result of the Reverse Stock Split, the number of issued and outstanding shares of the Company’s Common Stock immediately prior to the Reverse Stock Split was reduced to a smaller number of shares, such that every twelve shares of the Company’s Common Stock held by a stockholder immediately prior to the Reverse Stock Split were combined and reclassified into one share of the Company’s Common Stock. Immediately following the Reverse Stock Split, but prior to the completion of the Merger and Private Placement, there were approximately 3,122,466 shares of Zafgen Common Stock outstanding.
From December 31, 2019 to March 01, 2020
Issuance of common stock upon exercise of stock options and employee stock purchase plan
Issuance of restricted stock units
from December 31, 2018 to December 31, 2019
Issuance of common stock upon exercise of stock options and employee stock purchase plan
Issuance of restricted stock units
From June 30, 2019 to September 30, 2019
Issuance of common stock upon exercise of stock options and employee stock purchase plan
Issuance of restricted stock units
From March 31, 2019 to June 30, 2019
Issuance of restricted stock units
from December 31, 2018 to March 31, 2019
Issuance of common stock upon exercise of stock options and employee stock purchase plan
Issuance of restricted stock units
from December 31, 2017 to December 31, 2018
Issuance of common stock, net of issuance costs
Issuance of common stock upon exercise of stock options and employee stock purchase plan
Issuance of restricted stock units
from December 31, 2016 to December 31, 2017
Issuance of common stock upon exercise of stock options and employee stock purchase plan
Issuance of common stock upon exercise of stock options and employee stock purchase plan
From December 31, 2015 to December 31, 2016
Issuance of common stock upon exercise of stock options and employee stock purchase plan
Issuance of common stock
Issuance of restricted stock units
From December 31, 2014 to December 31, 2015
Issuance of common stock
Issuance of common stock upon exercise of stock options and employee stock purchase plan
Issuance of restricted stock
A 1-for-6.28 reverse stock split of our common stock and a proportional adjustment to the existing conversion ratio of each series of our redeemable convertible preferred stock, which became effective on June 5, 2014.
The automatic conversion of all outstanding shares of our redeemable convertible preferred stock into an aggregate of 15,077,621 shares of our common stock upon the completion of this offering;
On June 5, 2014, the Company effected a 1-for-6.28 reverse stock split of its issued and outstanding shares of common stock and a proportional adjustment to the existing conversion ratios for each series of Redeemable Preferred Stock
from December 31, 2013 to March 31, 2014
Issuance of Series E redeemable convertible preferred stock, net of issuance costs of $1
from December 31,2012 to December 31,2013
Issuance of Series D redeemable convertible preferred stock, net of issuance costs of $1
Issuance of Series E redeemable convertible preferred stock, net of issuance costs of $156
Repurchase and retirement of common stock, at cost